2015 American Transplant Congress
CD8 T Cell Biomarkers Improves the Capacities of the Kidney Transplant Failure Score for the Long-Term Prognostic of Kidney Graft Failures
Background. Kidney transplantation is acknowledged as the treatment of choice for patients in end-stage renal disease compared to dialysis. We hypothesized that the efficiency of…2015 American Transplant Congress
Operational Tolerance in Kidney Transplantation: Results of a Europe-Wide Survey
BACKGROUND: Operational Tolerance (opTOL) is deemed to be extremely rare in kidney transplantation. We launched a Europe-wide survey to assess the frequency of opTOL.METHODS: 18…2015 American Transplant Congress
OX40 Gene: A Potential Target for the Care of Chronic T-Cell Mediated Rejection (TCMR)
Introduction:TCMR is characterized by the reduction of vessel lumen with marked intimal thickening, fibrous hyperplasia and a strong component of leukocyte infiltrate. Aim of our…2015 American Transplant Congress
Characterization of a Nude Mouse Model of Allosensitization Conditioned by Adoptive Transfer of Follicular T Helper Cells
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Background Follicular T helper (Tfh) cells play a critical role in follicular B cell activation and maturation during antibody responses to allograft. Here we report…2015 American Transplant Congress
Temporal Increase in the Incidence of Post-Transplantation Lymphoproliferative Disorder in Adult Renal Transplant Recipients: Analysis of 2 US Insurance Administrative Claims Databases
Bristol-Myers Squibb Company, Princeton, NJ.
Purpose: Post-transplant lymphoproliferative disorder (PTLD) is a serious complication after kidney transplant. In a prior analysis using Medicare claims database from 1995 to 2003, the…2015 American Transplant Congress
HLA-DR Matching Improves Immunologic Outcomes in Elderly Kidney Transplant Recipients
Nephrology, Charité Universitätsmedizin Berlin, Berlin, Germany.
BACKGROUND: The Eurotransplant senior program (ESP) neglects HLA matching for elderly (>65y) KTR. Only few data exist regarding the influence of HLA-DR-matching on immunologic outcomes.PATIENTS…2015 American Transplant Congress
The Role of Inflammasome Components in Renal Tubular Epithelial Cell Injury
Background:Inflammasomes are multiprotein complexes of pattern recognition receptors (PRRs) recognized as key triggers of cellular injury. TLRs provide the first signal for induction of the…2015 American Transplant Congress
Diabetes Exacerbates Liver Ischemia and Reperfusion Injury By Activating the AGE-RAGE Pathway in Kupffer Cells
Surgery, UCLA, Los Angeles, CA.
Although pre-transplant diabetes has been documented as a risk factor for mortality post-liver transplant, the underlying mechanism remains obscure. In a murine liver partial warm…2015 American Transplant Congress
NK Cells of Kidney Transplant Recipients Show a Reduced Capacity to Produce Cytokines But Retain Their Cytotoxic Capacity
The role of NK cells in either graft rejection or tolerance induction is still discussed controversially. In order to clarify the effect of long-term immunosuppression…2015 American Transplant Congress
Pharmacokinetics of Everolimus (EVL) in Elderly Recipients Under Low-Tacrolimus(TAC)/Everolimus in the First Year After Renal Transplantation. Data from the NEverOLd Trial
Elderly ( >60 years) recipients are being renal transplanted more frequently. The pharmacokinetics studies (PK) of immunosuppressive drugs in healthy volunteers, rarely, if ever, include…
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