2015 American Transplant Congress
Quantifying Altruism in Kidney Donors: How Good Are the Current Scales?
The decision to become a living kidney donor is complicated and altruism is certainly what drives the majority of organ donors. Unfortunately, there are no…2015 American Transplant Congress
Lung Transplantation from Donors With Kidney Disease
Duke University Medical Center, Durham, NC.
Background:Various donor characteristics are associated with decreased survival following single (SLT) or bilateral (BLT) lung transplantation. No current studies exist regarding use of lungs from…2015 American Transplant Congress
Excellent Outcomes With Kidney Transplantation for Patients ≥70 Years of Age
BackgroundOur aim was to determine the outcomes following kidney transplantation in recipients ≥70 years of age at the time of transplantation.Materials and MethodsWe analyzed data…2015 American Transplant Congress
Pro-Inflammatory Actions of New Non-HLA Antibodies Targeting Protease-Activated Receptor (PAR-1)
Microvascular endothelium is major target for antibodies directed against HLA and non-HLA antigens. Functional antibodies targeting G-protein coupled receptors (GPCRs) such as AT1R or ETAR…2015 American Transplant Congress
Pharmacogenetic Variation in Renal Calcineurin Inhibitor (CNI) Metabolism and the Response of Allograft-Derived Proximal Tubule Cells
Background: Multiple studies have demonstrated the importance of genetic variation in CYP3A5 and ABCB1 for calcineurin inhibitor (CNI) disposition and CNI-related nephrotoxicity. Renal CNI metabolism…2015 American Transplant Congress
Accurate Prediction of High-Resolution HLA-A, -B, -C, -DRB1 and -DQB1 Typing and Low-Resolution HLA-DQA1 Typing by Haplotype Analysis
Aim: Allele-specific HLA antibodies are commonly detected by Luminex single antigen bead assays in solid organ transplant recipients. However, high-resolution HLA typing for deceased donors…2015 American Transplant Congress
Moderate Rejection Episode of Face Transplant After mTOR Conversion to Preserve Renal Function
1University of Maryland School of Medicine, Baltimore; 2New York Medical University, New York City.
Face and hand vascularized composite allografts (VCA) have demonstrated durable graft survivals with conventional immunosuppression but with the appearance of renal dysfunction. Management strategies that…2015 American Transplant Congress
Glomerulosclerosis Patterns Are Non-Uniform Throughout the KDPI Spectrum With Impact on Biopsy Evaluation of Kidneys for Transplant
1Gift of Hope Organ & Tissue Donor Network, Itasca, IL; 2Rush University, Chicago, IL.
Background: The kidney donor profile index (KDPI) stratifies kidney quality with direct bearing on organ allocation and utilization. Procurement biopsy is commonly performed and factored…2015 American Transplant Congress
T-Cell Depletion Versus Interleukin-2 Antagonists in a Kidney Transplant Model of Sensitized Rhesus Macaques
[Background] Sensitized patients comprise up to a third of the kidney waiting list. Preformed and newly formed alloantibodies post transplantation (TX) deteriorate graft survival, recall…2015 American Transplant Congress
Racial Disparities in Access to Kidney Re-Transplantation in the United States
Surgery, Emory Transplant Center, Atlanta, GA.
Introduction: The number of patients with a failed kidney transplant who are being considered for re-transplantation has steadily increased over the past few years. It…
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