ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Quantifying Altruism in Kidney Donors: How Good Are the Current Scales?

    M. McLaughlin, D. Berglund, A. Matas, H. Ibrahim.

    U of MN, Mpls.

    The decision to become a living kidney donor is complicated and altruism is certainly what drives the majority of organ donors. Unfortunately, there are no…
  • 2015 American Transplant Congress

    Lung Transplantation from Donors With Kidney Disease

    A. Ganapathi, B. Gulack, A. Castleberry, R. Davis, L. Snyder, M. Hartwig.

    Duke University Medical Center, Durham, NC.

    Background:Various donor characteristics are associated with decreased survival following single (SLT) or bilateral (BLT) lung transplantation. No current studies exist regarding use of lungs from…
  • 2015 American Transplant Congress

    Excellent Outcomes With Kidney Transplantation for Patients ≥70 Years of Age

    D. Haakinson,1 K. Reddy,1 A. Moss,1 N. Katariya,1 A. Singer,1 A. Mathur,1 J. Huskey,2 H. Khamash,2 R. Heilman.2

    1Transplant Surgery, Mayo Clinic Arizona, Phoenix, AZ; 2Nephrology, Mayo Clinic Arizona, Phoenix, AZ.

    BackgroundOur aim was to determine the outcomes following kidney transplantation in recipients ≥70 years of age at the time of transplantation.Materials and MethodsWe analyzed data…
  • 2015 American Transplant Congress

    Pro-Inflammatory Actions of New Non-HLA Antibodies Targeting Protease-Activated Receptor (PAR-1)

    R. Catar,1 C. Luecht,1 M. Simon,1 A. Philippe,1 A. Kusch,1 M. Szczepek,2 P. Hildebrand,2 P. Scheerer,2 D. Dragun.1

    1Nephrology and Intensive Care Medicine, Charité, Berlin, Germany; 2Institute of Medical Physics and Biophysics, Charité, Berlin, Germany.

    Microvascular endothelium is major target for antibodies directed against HLA and non-HLA antigens. Functional antibodies targeting G-protein coupled receptors (GPCRs) such as AT1R or ETAR…
  • 2015 American Transplant Congress

    Pharmacogenetic Variation in Renal Calcineurin Inhibitor (CNI) Metabolism and the Response of Allograft-Derived Proximal Tubule Cells

    N. Knops,1,2 L. van den Heuvel,2 R. Masereeuw,3 H. de Loor,4 E. Levtchenko,1,2 D. Kuypers.5,4

    1Pediatric Nephrology and Solid Organ Transplantation, University Hospitals Leuven, Leuven, Belgium; 2Laboratory for Pediatrics, Dept. Development & Regeneration, KU Leuven, Leuven, Belgium; 3Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, Netherlands; 4Laboratory of Nephrology, University Hospitals Leuven, Leuven, Belgium; 5Nephrology and Solid Organ Transplantation, University Hospital Leuven, Leuven, Belgium.

    Background: Multiple studies have demonstrated the importance of genetic variation in CYP3A5 and ABCB1 for calcineurin inhibitor (CNI) disposition and CNI-related nephrotoxicity. Renal CNI metabolism…
  • 2015 American Transplant Congress

    Accurate Prediction of High-Resolution HLA-A, -B, -C, -DRB1 and -DQB1 Typing and Low-Resolution HLA-DQA1 Typing by Haplotype Analysis

    A. Jaramillo,1 R. Vaidya,2 M. Pando,3 S. Gaitonde.4

    1Histocompatibility & Immunogenetics Laboratory, Gift of Hope Organ & Tissue Donor Network, Itasca, IL; 2College of Pharmacy, Roseman University of Health Sciences, South Jordan, UT; 3Department of Laboratory Medicine & Pathology, Mayo Clinic, Phoenix, AZ; 4Department of Pathology, University of Illinois, Chicago, IL.

    Aim: Allele-specific HLA antibodies are commonly detected by Luminex single antigen bead assays in solid organ transplant recipients. However, high-resolution HLA typing for deceased donors…
  • 2015 American Transplant Congress

    Moderate Rejection Episode of Face Transplant After mTOR Conversion to Preserve Renal Function

    R. Barth,1 B. Bojovic,1 J. Woodall,1 M. Uluer,1 C. Drachenberg,1 C. Shaffer,1 N. Kelly,1 E. Rodriguez,2 S. Bartlett.1

    1University of Maryland School of Medicine, Baltimore; 2New York Medical University, New York City.

    Face and hand vascularized composite allografts (VCA) have demonstrated durable graft survivals with conventional immunosuppression but with the appearance of renal dysfunction. Management strategies that…
  • 2015 American Transplant Congress

    Glomerulosclerosis Patterns Are Non-Uniform Throughout the KDPI Spectrum With Impact on Biopsy Evaluation of Kidneys for Transplant

    M. Jendrisak,1 K. Mulawa,1 M. Harmon,1 D. Cimbaluk.2

    1Gift of Hope Organ & Tissue Donor Network, Itasca, IL; 2Rush University, Chicago, IL.

    Background: The kidney donor profile index (KDPI) stratifies kidney quality with direct bearing on organ allocation and utilization. Procurement biopsy is commonly performed and factored…
  • 2015 American Transplant Congress

    T-Cell Depletion Versus Interleukin-2 Antagonists in a Kidney Transplant Model of Sensitized Rhesus Macaques

    C. Burghuber,1,2 J. Kwun,1 E. Page,1 F. Leopardi,3 A. Gibby,1 A. Farris,1 N. Iwakoshi,1 S. Knechtle.1

    1Emory University, Atlanta, GA; 2Medical University Vienna, Vienna, Austria; 3Duke University, Durham, NC.

    [Background] Sensitized patients comprise up to a third of the kidney waiting list. Preformed and newly formed alloantibodies post transplantation (TX) deteriorate graft survival, recall…
  • 2015 American Transplant Congress

    Racial Disparities in Access to Kidney Re-Transplantation in the United States

    C. Garrett, R. Patzer, R. Zhang, A. Adams.

    Surgery, Emory Transplant Center, Atlanta, GA.

    Introduction: The number of patients with a failed kidney transplant who are being considered for re-transplantation has steadily increased over the past few years. It…
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