2022 American Transplant Congress
Increased Waitlist Mortality in Pediatric Liver Transplant Candidates with Greater Distance from Transplant Center
Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Greater distance from transplant center in adult liver transplant (LT) candidates is associated with increased waitlist mortality. Pediatric LT candidates have higher waitlist mortality…2022 American Transplant Congress
25 Years of a Standardized Living Donor (LD) Intestinal Transplant Technique – What Has Been Achieved?
1SUNY Downstate Medical Center, Brooklyn, NY, 2SUNY Downstate Medical Center, Brooklyn, MA
*Purpose: The indication for intestinal transplantation (ITX) is irreversible intestinal failure with dependence on total parenteral nutrition (TPN). Most intestinal transplants are from deceased donors…2022 American Transplant Congress
Perfusate Metabolites and Association with Pump Perfusion and Allograft Failure
*Purpose: While hypothermic machine perfusion (HMP) is associated with improved kidney graft viability, the exact biological mechanisms underlying this association are unknown. The goal of…2022 American Transplant Congress
T Cell Overexpression of PD-1 Increases Treg Suppressive Function via an ICOS-Dependent Mechanism
*Purpose: The PD-1: PD-L1 signaling has inhibitory properties and is a potential therapeutic target in transplantation. We have previously demonstrated that overexpression of PD-1 on…2022 American Transplant Congress
Dynamic Changes in Titer and Specificity Autoantibodies in Chronic Bm12 to B/6 Kidney Rejection
*Purpose: Loss of autoreactive B cell tolerance and production of non-HLA autoantibodies have been observed in patients undergoing chronic rejection, however, how autoreactive B cells…2022 American Transplant Congress
Molecular Characterization of the Plasma Secretome in Pediatric Liver Transplantation (pLTx) Identified Cytokine/Chemokine Signatures Potentially Linked to Beneficial Immunosuppressive Regimes (IS) and Recovery
*Purpose: In the European multicentre “ChilSFree” study we aimed to characterize longitudinal dynamics of soluble immune mediators during the first year after pLTx.*Methods: Using Luminex-based…2022 American Transplant Congress
Antibody-Mediated Allograft Rejection is Associated with an Increase in Peripheral Differentiated Cd28-cd8+ T Cells – Analyses of a Cohort of 1032 Kidney Transplant Recipients
*Purpose: CD28-CD8+ T cells represent a differentiated CD8+ T cell subset that is found to be increased in various conditions associated with chronic antigenic stimulation…2022 American Transplant Congress
Use of Everolimus and Reduced Calcineurin Inhibitors in Bk Nephropathy: Insights from Follow-Up and Surveillance Biopsies
Cleveland Clinic, Cleveland, OH
*Purpose: BK virus-associated nephropathy (BKVAN) is a clinically important entity that results in an allograft loss in kidney transplant recipients (KTRs). Mammalian target of rapamycin…2022 American Transplant Congress
Characterisation of Kidney-Specific Extracellular Vesicles During Isolated Organ Normothermic Machine Perfusion
*Purpose: Introduction: Normothermic machine perfusion (NMP) can evaluate and recondition deceased-donor kidneys but accurate biomarkers are needed to assess organ quality and to predict post-transplant…2022 American Transplant Congress
Comparison of IGG and IGM Type B Cell Receptor-Mediated MTOR Phosphorylation Signal
Division of Transplant Immunology, Division of Transplant Immunology, Tokyo, Japan
*Purpose: IgG and IgM memory B cells (mBCs) corresponding donor-specific antigen are closely involved in the activation of humoral immunity against transplanted grafts. Therefore, it…
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