Am J Transplant, Volume 22, Suppl 3 Archives - Page 43 of 190 - ATC Abstracts

2022 American Transplant Congress
Moving Beyond the Waitlist in Measurement of Access in Kidney Transplantation
L. C. McMichael, D. T. Chang, M. Kadatz, J. Gill
University of British Columbia, Vancouver, BC, Canada
*Purpose: Studies limited to waitlist candidates have suggested better access to kidney transplantation and fewer disparities in acesss since the new kidney allocation system (KAS)…
2022 American Transplant Congress
Characterization of ICU Delirium Among Liver Transplant Recipients
J. M. Ruck, K. Neufeld, E. Oh, J. C. Lai, E. King
Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Delirium has been shown to impact the hospital courses of older adults. Liver transplant (LT) recipients are a population that has previously been identified…
2022 American Transplant Congress
Artificial Intelligence Based Dosing of Tacrolimus in Liver Transplantation: Prospective, Randomized Phase 2 Trial
A. Zarrinpar¹, C. Ho², C. Warren¹, J. Khong², M. Lee², S. Duarte¹, K. Andreoni¹, M. Johnson¹, N. Battula³, D. McKimmy¹, T. Beduschi¹
¹Surgery, University of Florida, Gainesville, FL, ²Mechanical and Aerospace Engineering, University of California, Los Angeles, CA, ³Surgery, University of Oklahoma, Oklahoma City, OK
*Purpose: Inter- and intra-individual variability in calcineurin dose requirements necessitates empirical clinician-titrated dosing that frequently results in deviation from target ranges, particularly during the critical…
2022 American Transplant Congress
Evaluation of Hepatitis C Positive Donor to Hepatitis C Negative Recipient Kidney Transplant in a Highly Sensitized Patient Population
A. T. Iaria, M. Martin, A. Hietpas, I. Tang, S. Koppe, I. Tzvetanov, E. Benedetti, C. Muran
University of Illinois at Chicago, Chicago, IL
*Purpose: This study assessed outcomes of hepatitis C virus (HCV) donor positive to recipient negative (D+/R-) kidney transplants (KT) in high immunologic risk patients. Literature…
2022 American Transplant Congress
Iguratimod Alleviates Endothelial to Mesenchymal Transition by Inducing AMBRA1/PARKIN-Dependent Mitophagy and Inhibiting NLRP3 Activation During Renal Allograft Interstitial Fibrosis
Z. Gui¹, W. Zijie², M. Zheng³, R. Tan³, M. Gu⁴
¹Department of Urology, The Second Affiliated Hospital with Nanjing Medical University, Nanjing, China, ²Jiangsu Province Hospital, Nanjing, China, ³Department of Urology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China, ⁴Department of Urology, the Second Affiliated Hospital with Nanjing Medical University, Nanjing, China
*Purpose: Chronic renal graft dysfunction (CAD) is caused by multiple factors, including glomerular sclerosis, inflammation, interstitial fibrosis and tubular atrophy (IF/TA). However, the most prominent…
2022 American Transplant Congress
Alloreactive Human Regulatory T Cell-Derived Extracellular Vesicles Exhibit Adenosinergic Mediated Suppression and Potential for Infectious Tolerance
B. Schreiber, S. Tripathi, A. Chandraker
Brigham and Women's Hospital, Boston, MA
*Purpose: Regulatory T cells (Tregs) suppress the immune response through both contact dependent and independent mechanisms. Extracellular vesicles (EVs) are emerging as novel contact independent…
2022 American Transplant Congress
Triple-Knockout Pig Red Blood Cells as Potential Sources for Blood Transfusion in Alloimmunized Patients with Sickle Cell Disease
T. Yamamoto¹, M. H. Bikhet², H. Q. Nguyen², Y. Cui², M. Javed², S. S. Raza², D. Ayares³, H. Iwase², H. Hara², D. K. Cooper¹
¹Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, ²Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, ³Revivicor, Blacksburg, VA
*Purpose: Blood transfusion remains important in the treatment of patients with sickle cell disease (SCD). However, alloimmunization after multiple blood transfusions is associated with patient…
2022 American Transplant Congress
Increased Baboon Chimerism After Peripheral Blood Stem Cell Infusion from a Novel GalTKO Pig with Functional Humanized Il-3 Receptor
E. M. Duggan, N. P. Llore, J. M. Stern, H. Sakai, B. Piegari, K. Bruestle, D. Hajosi, B. Bhola, F. Huang, D. Ekanayake-Alper, D. H. Sachs, M. Sykes, R. J. Hawley, A. D. Griesemer
Columbia University Irving Medical Center, New York, NY
*Purpose: The purpose of this study was to investigate whether expression of a humanized IL-3 receptor (hCD123+hCD131) transgene in a GalTKO pig would improve levels…
2022 American Transplant Congress
Implementation of Infectious Disease Surveillance in Recently Deceased Human Xenograft Study
S. J. Cawthon, E. P. Weldon, N. S. Lawson, B. E. Lonze, R. A. Montgomery, S. A. Mehta
NYU Langone Transplant Institute, New York, NY
*Purpose: Xenotransplantation is a promising solution for the ongoing organ shortage but has been slow to develop because of both immunological challenges and potential risk…
2022 American Transplant Congress
RBBP7 as a Novel Biomarker for the Molecular Diagnosis of BK Virus-Associated Nephropathy
W. Yicun, W. Yuxuan, H. Xiaopeng
Department of Urology, Beijing Chaoyang Hospital, Beijing, China
*Purpose: BK virus-associated nephropathy (BKVN) remains a major infectious complication of kidney transplantation, and its histologic appearance can mimic rejection, leading to a diagnostic dilemma…