Am J Transplant, Volume 22, Suppl 3 Archives - Page 181 of 190 - ATC Abstracts

2022 American Transplant Congress
Impact of the COVID-19 Pandemic on CMS Organ Procurement Organization Performance Metrics
N. Dzebisashvili¹, K. Lentine², D. Axelrod³, K. Venkataramani¹, K. Axelrod¹, M. A. Schnitzler²
¹CareDx, South San Francisco, CA, ²Saint Louis University, St Louis, MO, ³University of Iowa, Iowa City, IA
*Purpose: CMS introduced new performance metrics for Organ Procurement Organizations (OPO). CDC death records define donation eligible deaths, the denominator of the donation and transplant…
2022 American Transplant Congress
Infections in Kidney Transplant Recipients on Belatacept versus Tacrolimus-Based Immunosuppression
S. Gattis¹, A. Basu²
¹Emory Healthcare, Atlanta, GA, ²Emory University Hospital, Atlanta, GA
*Purpose: Patients 70 years and older with advanced/ end stage kidney disease are increasingly receiving kidney transplants. Immediately post- transplant, our center utilizes Belatacept coupled…
2022 American Transplant Congress
Blood Transcriptomes of Kidney Recipients with Covid-19 Demonstrate Deficient Adaptive Immune Activation
K. Banu¹, Z. Sun², Y. A. Azzi³, M. M. Rana⁴, A. Reghuvaran¹, G. Carrara⁵, S. Hartell⁴, W. Asch¹, W. Zhang⁴, Z. Zhang², E. Akalin³, P. Cravedi², P. Heeger², K. Banu¹
¹Nephrology, Yale University, New Haven, CT, ²Icahn School of Medicine at Mount Sinai, New York, NY, ³Montefiore Medical Center, New York, NY, ⁴Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY, ⁵Icahn School of Medicine at Mount Sinai, New Haven, CT
*Purpose: Kidney transplant recipients (KTRs) have poor outcomes compared to non-KTRs with acute COVID-19. To provide insight into management of immunosuppression (IS) during COVID-19, we…
2022 American Transplant Congress
Optimal Development and Effector Function of Antibody-Suppressor CXCR5⁺CD8⁺ T Cells Requires Host IFN-γ and CD4⁺ T Cells
J. Zimmerer, S. Chaudhari, M. Hart, J. Han, K. Koneru, G. Bumgardner
OSUWMC, Columbus, OH
*Purpose: We reported the discovery of a novel subset of CXCR5+IFNγ+CD8+ T cells that suppresses antibody production (CD8+ TAb-supp cells). Alloprimed CD8+ TAb-supp cells significantly…
2022 American Transplant Congress
Why is Adolescent Waitlist Mortality Higher for Status 1A Girls?
J. Foutz¹, E. Hsu², S. Noreen³, M. Cafarella⁴, J. Pomposelli⁵, S. Biggins⁶, J. Reyes⁶, E. Perito⁷
¹Research, United Network for Organ Sharing, Richmond, VA, ²Seattle Children's Hospital, Seattle, WA, ³United Network for Organ Sharing, Richmond, VA, ⁴Policy and Community Relations, United Network for Organ Sharing, Richmond, VA, ⁵University of Colorado, Aurora, CO, ⁶University of Washington, Seattle, WA, ⁷UCSF, San Francisco, CA
*Purpose: Although adolescent pediatric liver transplant candidates are a vulnerable population, they are often excluded from analyses due to small sample size and assignment of…
2022 American Transplant Congress
Tocilizumab in Chronic Active Antibody-Mediated Rejection in Kidney Transplant Recipients: A Case Series
B. Boonpheng¹, R. Bakthavatsalam², C. D. Blosser¹, I. C. De Castro¹, I. Gimferrer³, Y. Ng¹, N. Leca¹
¹Nephrology, University of Washington, Seattle, WA, ²Surgery, University of Washington, Seattle, WA, ³Bloodworks Northwest, Seattle, WA
*Purpose: The optimal treatment for chronic active antibody-mediated rejection (ca-AMR) remains unclear. Tocilizumab (TCZ), a monoclonal antibody against IL-6, has been proposed in ca-AMR treatment…
2022 American Transplant Congress
Treatment of BK Virus with Weekly Intravenous Immunoglobulin in Adult Kidney Transplant Recipients
G. Girone¹, W. Asch²
¹Department of Pharmacy, Yale New Haven Hospital, New Haven, CT, ²Section of Nephrology, Yale School of Medicine, New Haven, CT
*Purpose: The typical management of Polyoma BK virus (BKV) in kidney transplant recipients (KTR) includes reducing immunosuppression (IS). Intravenous immunoglobulin (IVIG) has been utilized for…
2022 American Transplant Congress
Removing DSA and Region from Organ Allocation
R. R. Goff¹, A. R. Wilk¹, J. Foutz¹, A. Robinson¹, S. E. Booker¹, K. Bradbrook¹, T. Mupfudze¹, N. Turgeon², M. Cooper³, D. Klassen¹
¹United Network for Organ Sharing, Richmond, VA, ²University of Texas at Austin, Austin, TX, ³Medstar Georgetown, Washington , D.C., DC
*Purpose: Over the past 4 years, the OPTN has removed Donation Service Area (DSA) and OPTN Region from deceased donor organ allocation with the goal…
2022 American Transplant Congress
Immunosuppressants Alter Lymph Node Architecture and Create Distinct Microbiome Footprints
S. J. Gavzy¹, R. Lakhan², J. Iyyathurai², V. Saxena², L. Li², B. Ma², E. Mongodin², J. S. Bromberg²
¹University of Maryland School of Medicine, Baltimore, MD, ²University of Maryland, Baltimore, MD
*Purpose: There are complex interactions among immunosuppressants, antibiotics, and the gut microbiome on the host immune system. Microbiota can alter lymph node (LN) structure and…
2022 American Transplant Congress
Single-Cell Multiomics Defines Tolerogenic Extrathymic Aire-Expressing Cells
A. R. Gupta¹, J. Wang², C. Lareau³, I. Sun², J. Bautista¹, J. Gardner¹
¹Department of Surgery, University of California San Francisco, San Francisco, CA, ²Diabetes Center, University of California San Francisco, San Francisco, CA, ³Department of Pathology, Stanford University, Stanford, CA
*Purpose: The Autoimmune Regulator (Aire) gene, essential for central tolerance through its regulation of tissue-specific antigens in medullary thymic epithelial cells, is also expressed in…