Am J Transplant, Volume 22, Suppl 3 Archives - Page 14 of 190 - ATC Abstracts

2022 American Transplant Congress
PD-1 Expression on CD8+ T Cells Contributes to the Establishment of Mixed Chimerism-Based Operational Tolerance
C. J. Little, S. C. Kim, J. Fechner, J. Post, M. Winslow, D. B. Kaufman
Surgery, University of Wisconsin, Madison, WI
*Purpose: PD-1 is a T cell co-inhibitory molecule involved in T cell exhaustion and antigen specific hypo-reactivity. Given the role of PD-1 signaling in the…
2022 American Transplant Congress
Clinical Impact of a Modified Lung Allocation Score That Mitigates Selection Bias
E. M. Schnellinger¹, E. Cantu², D. E. Schaubel¹, S. E. Kimmel³, A. J. Stephens-Shields¹
¹University of Pennsylvania, Philadelphia, PA, ²Hospital of the University of Pennsylvania, Philadelphia, PA, ³University of Florida, Gainesville, FL
*Purpose: The U.S. lung allocation system uses the Lung Allocation Score (LAS) to prioritize lung transplant candidates. Selection bias, induced by dependent censoring of waitlisted…
2022 American Transplant Congress
Evaluation of Different Initial Tacrolimus Dosing Regimens in Pediatric Post-Liver Transplantation
A. F. Alghanem¹, A. Alsmari¹, H. Joharji²
¹Pharmaceutical Care, King Abdulaziz Medical City, Riyadh, Saudi Arabia, ²Pharmaceutical Care, King Faisal Specialized Hospital and Research Center, Riyadh, Saudi Arabia
*Purpose: Tacrolimus is an immunosuppressant used in post-liver transplantation, has wide pharmacokinetic variability, particularly in pediatric patients. Therefore, this study aimed to evaluate different weight-based…
2022 American Transplant Congress
Circulating and Intragraft Donor (HLA)-Specific B Cells Drive Allograft Rejection After Kidney Transplantation
A. Torija¹, N. Bolaños¹, L. Donadeu¹, M. Meneghini², I. Torres², A. Gabaldon², M. Gomà³, E. Crespo¹, F. Moreso⁴, O. Bestard²
¹Vall d'Hebron Research Institute (VHIR), Barcelona, Spain, ²Vall d'Hebron University Hospital, Barcelona, Spain, ³Bellvitge University Hospital, Barcelona, Spain, ⁴Vall d'Heron University Hospital, Barcelona, Spain
*Purpose: Besides donor-specific antibodies (DSA), circulating donor(HLA)-specific memory B cells (mBc) have also shown to play a deleterious role driving antibody-mediated rejection (ABMR) in kidney…
2022 American Transplant Congress
Regulatory T Cells Suppress Memory IFN-Gamma Production in Highly Sensitised Patients
C. Dudreuilh¹, S. Basu¹, O. Shaw², H. Burton¹, C. Domingo-Vila¹, T. Tree¹, G. Lombardi¹, C. Scotta¹, A. Dorling¹
¹King's College London, London, United Kingdom, ²Viapath Clinical Transplantation Laboratory, Guy's Hospital, London, United Kingdom
*Purpose: Highly sensitized patients (HS) present worse long-term outcome after transplantation compared to those without donor-specific antibodies (DSA). It has been suggested that desensitisation using…
2022 American Transplant Congress
Local Intragraft Humoral Immune Response in Chronic Lung Allograft Dysfunction
E. Miyamoto¹, S. C. Juvet², D. Vosoughi², J. Wang², J. Al-Refaee², T. Daigneault², A. Duong², S. Moshkelgosha², S. Keshavjee², K. Tinckam², A. Chruscinski³, D. Hwang⁴, T. Martinu²
¹Tenri Hospital Japan, University Health Network Canada, Nara, Japan, ²University Health Network, Toronto, ON, Canada, ³Multi-Organ Transplantation, University Health Network, Toronto, ON, Canada, ⁴Sunnybrook Health Science Centre, Toronto, ON, Canada
*Purpose: Donor HLA-specific antibody (DSA) and antibody against self-antigens (self-antigen antibody) can cause injury and lead to chronic lung allograft dysfunction (CLAD) after lung transplantation…
2022 American Transplant Congress
Cognitive Impairment In Liver Transplant Recipients 6 Months Or More After Transplant
K. Berry¹, L. Gaynor¹, F. Barry¹, E. Tsoy¹, C. Goode¹, R. Wong¹, S. Erlhoff¹, L. VandeVrede¹, K. Possin¹, J. C. Lai²
¹University of California, San Francisco, San Francisco, CA, ²University of California San Francisco, San Francisco, CA
*Purpose: Patients with decompensated cirrhosis awaiting liver transplant (LT) exhibit a spectrum of neurocognitive disorders, largely attributed to hepatic encephalopathy (HE) and considered reversible after…
2022 American Transplant Congress
Ixazomib for Desensitization (IXADES): Results of a Phase II Clinical Trial
N. Wilson¹, S. R. Reese², L. Ptak³, F. Aziz², S. Parajuli², V. Jucaud⁴, S. Denham⁴, A. Mishra⁵, P. Hematti⁵, A. Djamali²
¹University of Wisconsin, Madison, WI, ²Medicine, University of Wisconsin, Madison, WI, ³Administration, University of Wisconsin, Madison, WI, ⁴Terasaki Institute, Los Angeles, CA, ⁵UW Comprehensive Cancer Center, University of Wisconsin, Madison, WI
*Purpose: Ixazomib is a second-generation oral proteasome inhibitor, FDA approved for the treatment of refractory multiple myeloma. The purpose of the study was (1) to…
2022 American Transplant Congress
Internal Validation of a Pre-Transplant Biomarker Panel to Predict Post-Transplant Mortality: The Liver Immune Frailty Index
G. G. Panayotova¹, D. T. Nguyen², E. A. Graviss², L. J. Minze², S. Simonishvili¹, Y. Qin¹, T. Ayorinde¹, G. Prakash¹, F. Paterno¹, L. Brown¹, A. Amin¹, X. C. Li², R. M. Ghobrial², J. V. Guarrera¹, K. E. Lunsford¹
¹Rutgers New Jersey Medical School, Newark, NJ, ²Houston Methodist Hospital, Houston, TX
*Purpose: Infection and sepsis are the greatest contributors to early post-liver transplant (LT) mortality. These often result from ongoing immune dysfunction, or “Immune Frailty”. We…
2022 American Transplant Congress
Immune Cell Phenotype of Acute Rejection of Pancreas Allografts by RNA Sequencing Analysis
C. Hughes, H. Yang, C. Snopkowski, C. Li, D. M. Dadhania, S. Sultan, C. Hartono, M. Suthanthiran, S. V. Seshan, T. Muthukumar
Weill Cornell Medicine, New York, NY
*Purpose: Long term survival of pancreas allografts are inferior to kidney allografts. Molecular mechanisms underpinning pancreas allograft rejection and failure have not been explored in…