Am J Transplant, Volume 22, Suppl 3 Archives - Page 15 of 190 - ATC Abstracts

2022 American Transplant Congress
Six-Month Antibody Kinetics and Durability After Three Doses of SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients
A. Abedon¹, J. Alejo¹, T. Chiang¹, J. Mitchell¹, J. Kim¹, L. Thomas¹, R. Avery¹, A. Tobian¹, A. Massie¹, M. Levan¹, D. Warren¹, J. Garonzik-Wang², D. Segev¹, W. Werbel¹
¹Johns Hopkins, Baltimore, MD, ²University of Wisconsin, Madison, WI
*Purpose: Some solid-organ transplant recipients (SOTRs) with low or negative antibody levels after a 2-dose mRNA vaccine series against SARS-CoV-2 experience boosting after a third…
2022 American Transplant Congress
Re-Infection with SARS-CoV-2 in Solid-Organ Transplant Recipients: Incidence Density and Convalescent Immunity Prior to Re-Infection
S. Morris¹, S. Anjan¹, S. Pallikkuth², P. Frattaroli³, S. Courel⁴, A. Fernandez⁵, A. Natori⁶, L. Abbo⁷, S. Pahwa², G. Guerra⁸, Y. Natori¹
¹Division of Infectious Disease, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, ²Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, ³Medicine, Jackson Memorial Hospital, Miami, FL, ⁴University of Miami Miller School of Medicine, Miami, FL, ⁵Infectious Disease Associates of Tampa Bay, Tampa Bay, FL, ⁶Division of Oncology, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, ⁷Division of Infectious Disease, Department of Medicine, University Of Miami Miller School of Medicine, Miami, FL, ⁸Division of Nephrology, Department of Medicine, University of Miami Jackson Memorial Hospital, Miami, FL
*Purpose: The purpose of this study was to study our cohort of adult solid organ transplant recipients who had been infected with SARS-CoV-2 to describe…
2022 American Transplant Congress
The Role Of Gut Microbiome In Optimum Dose Selection Of Tacrolimus For Kidney Transplant Recipients
M. Nayebpour¹, N. Koizumi¹, J. Melancon²
¹George Mason University, Arlington, VA, ²George Washington University Hospital, Washington, DC
*Purpose: This study aims to validate and apply a personalized optimal dose selection model for Tacrolimus (Tac) for kidney transplant recipients at the George Washington…
2022 American Transplant Congress
Donor/Recipient Variabilities and Dd-cfdna Level
I. Gani¹, L. Mulloy¹, R. Mallavarapu¹, M. Saeed¹, R. Kapoor², A. Mirza¹
¹Augusta University Medical Center, Augusta, GA, ²Southwest Kidney Institute, Phoenix, AZ
*Purpose: Donor-derived cell-free DNA such as AlloSure (CareDx) is used as a non-invasive biomarker for allograft rejection and allograft injury as increased dd-cfDNA is observed…
2022 American Transplant Congress
The Prevalence And Risk Factors Of De Novo Hepatitis B Virus Infection In Kidney Transplantation From Hepatitis B Antigen-positive Donors To Hbsag-negative Recipients
J. Wu¹, S. Yin¹, F. Zhang¹, L. Wu¹, X. Wang², T. Lin¹
¹urology, west china hospital, Chengdu, China, ²Urology, West China Hospital, Chengdu, China
*Purpose: To explore the prevalence and risk factors of de novo HBV infection (DNH) in kidney transplantation (KT) from HBsAg⁺ donors (D[HBsAg⁺]) to HBsAg-negative recipients…
2022 American Transplant Congress
Tacrolimus After Rabbit Antithymocyte Globulin And Infliximab Induction Immunosuppression In Kidney Transplantation
O. Viklicky¹, G. Bold², O. Bestard³, P. Hruba¹, I. Zahradka¹, N. M. Otto², M. Stein², A. Sefrin², S. Christakoudi⁴, P. M. Reinke²
¹Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ²Charité, Berlin, Germany, ³Vall d'Hebron, Barcelona, Spain, ⁴King's College, London, United Kingdom
*Purpose: Selective targeting of effector/memory T cells as induction immunosuppression has been discussed in kidney transplantation. Confidence-interval-estimation study may help to estimate range of the…
2022 American Transplant Congress
Higher Proinflammatory Cytokines Are Associated with Increased Antibody Titer After a Third Dose of SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients
A. H. Karaba¹, X. Zhu¹, S. E. Benner¹, O. Akinde¹, Y. Eby¹, K. H. Wang¹, S. Saraf², J. M. Garonzik-Wang³, S. L. Klein¹, J. R. Bailey¹, A. L. Cox¹, J. N. Blankson¹, C. M. Durand¹, D. L. Segev¹, W. A. Werbel¹, A. A. Tobian¹
¹Johns Hopkins University, Baltimore, MD, ²National Institute of Allergy and Infectious Diseases, Bethesda, MD, ³University of Wisconsin School of Medicine and Health, Madison, WI
*Purpose: Solid organ transplant recipients (SOTRs) are at increased risk for severe COVID-19 and exhibit lower antibody responses to SARS-CoV-2 vaccines. This study aimed to…
2022 American Transplant Congress
SARS-CoV-2 Infection is Associated with Greater Neutralizing Antibody Response Compared to Three Doses of Mrna-1273 Vaccine in Solid Organ Transplant Recipients
V. H. Ferreira, V. Hall, T. M. Marinelli, M. Ierullo, V. Kulasingam, A. Humar, D. Kumar
University Health Network, Toronto, ON, Canada
*Purpose: Prior studies suggest that two doses of mRNA vaccine in SOTR may result in lower antibody and T-cell responses relative to levels seen following…
2022 American Transplant Congress
Additional Dose of SARS-CoV-2 Vaccine Increases Neutralization Capacity in Solid Organ Transplant Recipients
Y. Yoo¹, J. Husson², T. Iraguha³, S. Niederhaus⁴, X. Wen⁵, A. Crane⁵, A. Carrier⁵, J. Avruch⁵, A. Ahuja⁶, M. Mathew⁷, S. Dahiya⁸, A. P. Rapoport⁸, D. Atanackovic⁸, K. K. Saharia²
¹Inst of Human Virology, Baltimore, MD, ²Div of Infect Diseases, Univ of Maryland School of Med. and Inst of Human Virology, Baltimore, MD, ³Univ of Maryland School of Med. and Greenebaum Comprehensive Cancer Center, Baltimore, MD, ⁴Dept of Surgery, Univ of Maryland School of Med., Baltimore, MD, ⁵Dept of Surgery, Univ of Maryland Med. Center, Baltimore, MD, ⁶Dept of Medicine, Univ of Maryland Med. Center, Baltimore, MD, ⁷Div of Infect. Diseases, Univ of Maryland Med. Center, Baltimore, MD, ⁸Dept of Medicine, Univ of Maryland School of Med. and Greenebaum Comprehensive Cancer Center, Baltimore, MD
*Purpose: Solid organ transplant recipients (SOTR) develop weak antibody responses after SARS-CoV-2 vaccination. Published data on neutralizing activity of plasma, a better measure of protection,…
2022 American Transplant Congress
The Impact of Maintenance Immunosuppressive Regimen on COVID-19 Outcomes Among Kidney Transplant Patients
T. V. Sandes-Freitas¹, L. Modelli de Andrade², L. Requião-Moura³, J. Medina-Pestana³, H. Tedesco-Silva³, A. on behalf of Covid-19 KT Brazil Study Group¹
¹Universidade Federal do Ceará / Unidade Pesquisa Clínica CH-UFC/EBSERH, Fortaleza, Brazil, ²Universidade Estadual Paulista - UNESP, Botucatu, Brazil, ³Universidade Federal de São Paulo / Hospital do Rim, São Paulo, Brazil
*Purpose: Compared to azathioprine (AZA), mycophenolate (MPA) is implicated in an increased risk of several viral infections. Contrariwise, mTOR inhibitors (mTORi) are protective. Therefore, the…