Am J Transplant, Volume 22, Suppl 3 Archives - Page 103 of 190 - ATC Abstracts

2022 American Transplant Congress
Aquaporin 4 is a Mediator of Essential Dendritic Cell Functions
M. Nicosia¹, A. M. Beavers¹, Y. Yamamoto¹, T. Thompson², T. Zindrick², A. Valujskikh¹
¹Inflammation and Immunity, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, ²Aeromics, Cleveland, OH
*Purpose: Aquaporins are a family of transmembrane water channels implicated in a broad range of physiological functions. We previously reported that Aquaporin 4 (AQP4) is…
2022 American Transplant Congress
A Pathway for Establishing Etiology of Kidney Failure: An Academic Transplant Center’s Experience with a Broad Kidney Gene Panel
R. Sodhi¹, K. Brossart², A. Desai¹, D. J. Arwindekar¹, H. Tabriziani², S. Akkina¹
¹Loyola University Medical Center, Maywood, IL, ²Natera, Inc., Austin, TX
*Purpose: Assessing genetic causes of kidney failure can inform pre-transplant decision making and may improve post-transplant outcomes. Here we describe an academic transplant center’s experience…
2022 American Transplant Congress
Fibrinolysis Shutdown Subtype of Early Allograft Dysfunction Represents the Predominant Cohort of Patients with Graft Failure Following Liver Transplantation
H. B. Moore¹, T. L. Nydam², M. Adams³, T. Ferrell¹, I. Rodriguez⁴, D. Yoeli¹, R. Choudhury¹, J. Pomposelli¹, E. A. Pomfret¹
¹University of Colorado, Aurora, CO, ²Univeristy of Colorado, Aurora, CO, ³Childrens Hospital Colorado, Aurora, CO, ⁴University of Colorado Anschutz Medical Campus, Aurora, CO
*Purpose: Early allograft dysfunction (EAD) is associated with an increased rate of graft failure in liver transplantation (LT), but a mechanism remains unclear. Recent experience…
2022 American Transplant Congress
A Machine Learning Model for Predicting Antibody Response to 2-Dose Sars-cov-2 MRNA Vaccine Series in Transplant Recipients
J. L. Alejo¹, J. Mitchell¹, T. Chiang¹, A. Abedon¹, W. Werbel¹, R. Avery¹, A. Tobian¹, A. Massie¹, J. Garonzik-Wang², D. Segev¹, S. Bae¹
¹JHU, Baltimore, MD, ²U of Wisconsin, Madison, WI
*Purpose: Understanding risk factors for impaired vaccine responses can guide strategies for testing, additional dose recommendations, and vaccine schedules to provide improved protection in solid…
2022 American Transplant Congress
Current State of Use of Hepatitis C Viremic Donor Organs in Negative Recipients in the United States: A National Survey
K. Ryland¹, K. Hattori², J. Steinbrink³, N. Theodoropoulos⁴, M. Ison⁵
¹Mayo Clinic, Jacksonville, FL, ²Duke university hospital, Durham, NC, ³Duke University, Durham, NC, ⁴University of Massachusetts Medical School, Worcester, MA, ⁵Northwestern University Comprehensive Transplant Center, Chicago, IL
*Purpose: Since the advent of direct-acting antiviral (DAA) therapy, use of hepatitis C (HCV) viremic donor organs in HCV negative recipients has become more common.…
2022 American Transplant Congress
Tracking of Donor Reactive T Cell Clones Can Be Used to Diagnose or Even Predict Kidney Transplant Rejection
J. M. Mathew¹, Y. Sambandam¹, M. Kandpal¹, J. He¹, G. Perottino¹, B. Banbury², P. Fields², L. Gallon¹, J. R. Leventhal¹
¹Northwestern University, Chicago, IL, ²Adaptive Biotechnologies, Seattle, WA
*Purpose: Transplant (Tx) rejection currently requires an invasive biopsy for diagnosis. We have tested if serial quantitation of donor reactive T cell clones (DRTC) can…
2022 American Transplant Congress
TIGIT Agonism Ameliorates Costimulation Blockade-Resistant Rejection by Increasing Quantity and Quality of Graft-Infiltrating Foxp3⁺ Treg
C. R. Hartigan, D. Liu, S. Laurie, M. L. Ford
Emory University Transplant Center, Emory University, Atlanta, GA
*Purpose: Belatacept-based immunosuppression confers fewer off-target toxicities compared to CNI but comes at a cost of increased incidence and severity of acute rejection, potentially due…
2022 American Transplant Congress
Prediction Model of Post-Donation Renal Function Using Dynamic Kidney CT Volumetry in Living Donor
S. Lim¹, J. Kwon², Y. Ko¹, H. Kwon¹, J. Jung¹, H. Kwon¹, Y. Kim¹, J. Park², K. Lee², S. Shin¹
¹Asan Medical Center, Seoul, Songpa, Korea, Republic of, ²Samsung Medical Center, Seoul, Gangnam, Korea, Republic of
*Purpose: The risk of renal failure after live kidney donation can be predicted based on various clinical information. We tried introduce a model to predict…
2022 American Transplant Congress
Organ Tracking Combined with Real-Time Communication to Reduce Organ Shipment Delays and Cit: The First Report of a Comprehensive, Scalable System for Organ Tracking and Communication in the United States
A. Melia¹, S. Pankow¹, C. Paydenkar¹, P. Summers¹, J. Scalea²
¹MediGO, Inc., Baltimore, MD, ²Surgery, University of Maryland, Baltimore, MD
*Purpose: Recent organ allocation strategies have elevated the complexity of organ shipment, increasing the organ travel time and distance. Despite these changes, logistics, time, and…
2022 American Transplant Congress
Multidimensional Prognostication Tool for Kidney Transplant Patient Survival: The Mortality Mbox
C. Debiais-Deschamps¹, O. Aubert¹, D. Yoo¹, G. Divard¹, C. Lefaucheur², C. Legendre³, A. Loupy¹
¹Université de Paris, PARCC, INSERM, Paris, France, ²Service de Transplantation Rénale, AP-HP, Hôpital Saint-Louis, Paris, France, ³Service de Transplantation Rénale Adulte, AP-HP, Hopital Necker, Paris, France
*Purpose: Predicting kidney transplant patient mortality has been hampered by registry-based studies and low level phenotyped cohorts without specific design towards mortality prediction. This represents…