2022 American Transplant Congress
CCR2 Antagonism Blocks Microbiota Pro-Inflammatory Effects on Lymph Node Architecture
1University of Maryland School of Medicine, Baltimore, MD, 2University of Maryland, Baltimore, MD
*Purpose: Fecal microbiota transfer (FMT) of Desulfovibrio desulfuricans (Desulfo) triggers a pro-inflammatory immune state, causing decreased laminin α4:α5 ratios in the lymph node (LN), increased…2022 American Transplant Congress
Utility of Cytomegalovirus T-Cell Immunity Panel to Predict CMV Infections in Lung Transplant Recipients
*Purpose: Given the limited data of cytomegalovirus T-cell immunity panels (CMV TCIP) in lung transplant recipients (LTR), we sought to describe our center’s experience with…2022 American Transplant Congress
Plasmapheresis and Rituximab for Prevention of Focal Segmental Glomerulosclerosis Recurrence Post-Kidney Transplantation
*Purpose: Primary focal segmental glomerulosclerosis (FSGS) recurs after kidney transplantation (KT) in 30-50% of recipients with a median time of 1.5 months post-KT. Recurrence is…2022 American Transplant Congress
Development of a Patient-Reported Outcome Measure of Neurological Side Effects from Immunosuppression in Kidney Transplant Recipients
*Purpose: Though kidney transplant is the optimal treatment for most individuals with end stage kidney disease, recipients experience significant side effects associated with their required…2022 American Transplant Congress
Pro- and Anti-Tolerogenic Microbiota Induce Distinct Gut Microbiome Metabolic Pathways and Loco-Regional Immune Responses
1University of Maryland School of Medicine, Baltimore, MD, 2University of Maryland, Baltimore, MD
*Purpose: Colitis-associated Desulfovibrio desulfuricans (Desulfo) induces pro-inflammatory cytokine responses in dendritic cell and macrophage cell lines as well as primary cells. In contrast, Bifidobacterium pseudolongum…2022 American Transplant Congress
Role of CD8+T Cells Exhaustion in Long Term Spontaneous Acceptance of Mouse Kidney Allograft
*Purpose: CD8+ T cells exhaustion has been shown to promote chronic viral infection and tumor development, resulting from long term exposure to foreign antigen. We…2022 American Transplant Congress
Fcγ Receptor-Positive Cells Play a Critical Role in Rejection of Allogeneic Bone Marrow Cells Mediated by Anti-Donor Antibodies
1Talaris, Louisville, KY, 2Talaris Therapeutics, Louisville, KY
*Purpose: Sensitization through prior exposure to MHC antigens results in an increased rate of graft rejection. We previously reported that humoral immunity is the primary…2022 American Transplant Congress
Assessment of Letermovir as Universal Prophylaxis for Cytomegalovirus Infection in Lung Transplant Recipients
*Purpose: Cytomegalovirus (CMV) poses a significant concern in the post-operative management of lung transplant (LT) recipients. Current recommended prophylactic strategies with ganciclovir (GCV) or valganciclovir…2022 American Transplant Congress
A Population-Based Analysis of Long-Term Outcomes Following Pediatric Acute Liver Failure Highlights High Risk Populations in Access to Transplant
*Purpose: Pediatric acute liver failure (PALF) is a potentially devastating illness that affects otherwise healthy children. Nearly 70% of children with PALF will recover, while…2022 American Transplant Congress
Marginal Zone Phenotype B Cells Are Required for Formation of Donor-Specific IgG After Allogeneic Sensitization
Department of Pathology, Johns Hopkins University, Baltimore, MD
*Purpose: The formation of allogeneic antibody directed against non-self MHC, termed donor-specific antibody (DSA), is a significant barrier to successful transplant outcomes. Pre-formed DSA limits…
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