2021 American Transplant Congress
The Metagenomic Landscape of Renal Transplant
1Emory University, Atlanta, GA, 2Surgery, Emory University, Atlanta, GA
*Purpose: The selective targeting of T cells in transplant immunosuppression medications leads to a high rate of viral infections. Different immunosuppression regimens have been shown…2021 American Transplant Congress
Post-Transplant Idiopathic Immune Complex Glomerulonephritis
University of Wisconsin, Madison, WI
*Purpose: The appropriate treatment for post-kidney transplant immune complex glomerulonephritis (ICGN) of unknown cause is unclear.*Methods: From 01/2004 to 12/2018, 71 patients were diagnosed with…2021 American Transplant Congress
Liver Dysfunction Following Lung Transplantation
*Purpose: To describe the incidence and risk factors for postoperative hepatic dysfunction (POHD) following lung transplantation (LT) and long-term outcomes for these patients.*Methods: We performed…2021 American Transplant Congress
Clinical Correlation of Frailty Measures and Evaluation of Complementary Molecular Frailty Biomarker Candidates in a Prospective National Cohort of Liver Transplant Candidates
*Purpose: Frailty is a clinical condition characterized by a loss of physiologic reserve and increased susceptibility to stressors. Molecular frailty biomarkers may reflect the dysregulation…2021 American Transplant Congress
Covid-19 Impact of the Pandemic Surge on Patients Waiting for Renal Transplantation at a Single New York City Transplant Center
Transplant, NYP - Columbia University Medical Center, New York, NY
*Purpose: There was a critical need to understand the impact that the COVID-19 pandemic had on our patients awaiting transplantation, including infection rates, morbidity, mortality,…2021 American Transplant Congress
Intrarenal B-cell Activating Factor (BAFF) Levels are Increased in Transplant Glomerulopathy
University of Wisconsin Madison, Madison, WI
*Purpose: Transplant glomerulopathy (TG), a key feature of chronic active antibody-mediated rejection (caABMR), is associated with allograft failure. B-cell activating factor (BAFF) is a cytokine…2021 American Transplant Congress
Reassessing TCMR in Kidney Transplant Indication Biopsies: Emerging Evidence for Partial Exhaustion in Late TCMR
1Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 2., ., AB, Canada
*Purpose: We rederived the MMDx rejection archetypes in an expanded set of 1679 kidney transplant biopsies to add power and potentially define heterogeneity in TCMR.…2021 American Transplant Congress
Mortality in Organ Transplant Recipients with Covid-19 Compared to Non-transplant or Waitlisted Patients: A Meta-analysis
Rhode Island Hospital/Brown University, Providence, RI
*Purpose: Organ transplant recipients (OTR) are considered at high risk for adverse outcomes from COVID-19. However, mortality rates range from 30%. Some studies found that…2021 American Transplant Congress
TIGIT Identifies Polyfunctional Donor-Specific CD4+ T Cells Lost After Kidney Transplantation
Nephrology and Transplantation, Erasmus MC, Rotterdam, Netherlands
*Purpose: Development of T-cell hyporesponsiveness to donor antigen may explain the substantial decrease in the risk for acute rejection in the years following kidney transplantation.…2021 American Transplant Congress
Conversion to Belatacept Based Immunosuppression Regimen in Kidney Transplant Patients: Lessons Learned
*Purpose: The costimulatory inhibitor, belatacept (Bela) has been shown to be an effective alternative in several clinical situations including calcineurin toxicity, de novo alloantibody formation…
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