Am J Transplant, Volume 21, Suppl 3 Archives - Page 88 of 139 - ATC Abstracts

2021 American Transplant Congress
Inhibition of Apoptosis During Ex Situ Liver Normothermic Machine Perfusion Decreases Reperfusion Injury and Improves Viability
S. Raigani¹, S. Baptista¹, A. Ohman², J. Santiago², I. Rosales¹, M. Heaney², J. Boylan², T. Coe¹, K. Uygun¹, J. Sanders², H. Yeh¹
¹Transplant Surgery, Massachusetts General Hospital, Boston, MA, ²Pediatric Endocrinology, Brown University, Providence, RI
*Purpose: Normothermic machine perfusion (NMP) is an ideal platform for delivery of novel therapeutics aimed at rehabilitation of discarded or marginal livers. We examined the…
2021 American Transplant Congress
Tissue Specific Antigen-presentation in VCA Transplantation
B. Kern¹, J. Mengwasser¹, A. Reutzel-Selke¹, M. I. Ashraf¹, D. Polenz¹, K. Fuehrer¹, S. Lippert¹, P. Tang¹, F. Martin¹, C. Witzel¹, I. M. Sauer¹, J. Pratschke¹, S. G. Tullius²
¹Dept. of Surgery, Charité Campus CCM|CVK, Universitaetsmedizin Berlin, Germany, Berlin, Germany, ²Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
*Purpose: Vascular Composite Tissue Allotransplantation (VCA) has become a clinical reality. High frequencies of acute rejections remain an unsolved problem. Here, we delineated components of…
2021 American Transplant Congress
Urinary Exosome Mrna Signature for the Diagnosis of Human Kidney Transplant Rejection
R. El Fekih¹, J. Hurley², V. Tadigotla², A. Alghamdi³, A. Srivastava⁴, C. Coticchia², J. Choi¹, H. Allos⁵, k. yatim⁵, J. Alhaddad⁵, S. Eskandari⁵, P. Chu⁵, A. Mihali⁵, I. Lape⁵, M. Lima Filho⁵, B. Ayoma⁵, A. Chandraker⁵, K. Safa⁶, J. Markmann⁶, L. Riella⁶, R. Formica⁷, J. Skog², J. Azzi⁵
¹Medecine, Brigham and Women Hospital, Boston, MA, ²Exosome Diagnostics, Boston, MA, ³Boston Children Hospital, Boston, MA, ⁴Center for Translational Metabolism and Health, Chicago, IL, ⁵Transplantation Research Center, Boston, MA, ⁶Massachusetts General Hospital, Boston, MA, ⁷Yale School of Medicine, New Haven, CT
*Purpose: Traditional biomarkers currently used to monitor the kidney allograft, such as creatinine and proteinuria, are late markers of injury and lack sensitivity, specificity and…
2021 American Transplant Congress
Dietary Intake and Mycophenolate Mofetil-related Diarrhea Following Kidney Transplantation
G. Onyeaghala¹, L. Teigen², B. Guo², Y. Doronin¹, M. Al-Kofahi², B. Wu², W. Guan², C. Staley², S. Riad², A. Matas², R. Remmel², W. Oetting², C. Dorr¹, P. Jacobson², A. Israni¹
¹Nephrology, Hennepin Healthcare Research Institute, Minneapolis, MN, ²University of Minnesota, Minneapolis, MN
*Purpose: The treatment of Mycophenolate mofetil (MMF) related diarrhea in kidney transplants recipients involves providing lower MMF doses more frequently to maintain the same daily…
2021 American Transplant Congress
Kidney Injury in Hematopoietic Cell Transplant (HCT) Recipients: Urinary Biomarkers to the Rescue
T. Salinas¹, C. Snopkowski¹, C. Li¹, K. Chen¹, M. Lubetzky¹, S. Salvatore¹, K. Van Besien¹, E. Jaimes², S. Hingorani³, S. Seshan¹, T. Muthukumar¹
¹NY Presbyterian- Weill Cornell Medical College, New York, NY, ²Memorial Sloan Kettering Cancer Center, New York, NY, ³University of Washington School of Medicine, Seattle, WA
*Purpose: Kidney injury is common in HCT recipients and can be the result of graft versus host/kidney disease. However, this has not been well characterized,…
2021 American Transplant Congress
Results of Litmus (nct 02541916): The Liver Immune Tolerance Bio Marker Utilization Study
A. Chruscinski¹, V. Rojas-Luengas¹, A. Issacher¹, L. Lilly¹, E. Renner¹, M. Epstein¹, O. Adeyi¹, S. Fischer¹, Z. Galvin¹, S. Moshkelgosha¹, E. Jaeckel², S. Juvet¹, N. Selzner¹, G. Levy¹
¹Multi-Organ Transplantation, University Health Network, Toronto, ON, Canada, ²Hannover Medical School, Hannover, Germany
*Purpose: Although it is known that some liver transplant recipients are operationally tolerant and can be weaned off immunosuppression (IS), there is not currently a…
2021 American Transplant Congress
A Payer’s Perspective: The Cost of Hemodialysis versus Living Donor Kidney Transplant for Kidney Failure Patients in Nigeria
J. Lang¹, I. James², D. Da Rocha Afodu¹, C. G. Okwuonu³, O. Ekwenna¹
¹University of Toledo College of Medicine and Life Sciences, Toledo, OH, ²Surgical Specialists of Charlotte, Matthews, NC, ³Department of Internal Medicine, Nephrology Unit, Federal Medical Centre, Umuahia, Abia State, Nigeria
*Purpose: To primarily quantify the costs of LDKT and HD in Nigeria from a ‘payer’s perspective’ and secondarily inform future cost-effectiveness studies to guide health…
2021 American Transplant Congress
Valganciclovir Dosing for Cytomegalovirus Prophylaxis in Pediatric Solid Organ Transplant Recipients; Single Center Experience
S. Alharbi¹, A. Aljedai², D. Alkortas²
¹Pharmaceutical Care Division, KFSH&RC, riyadh, Saudi Arabia, ²Pharmaceutical Care Division, KFSH&RC, Riyadh, Saudi Arabia
*Purpose: The main objective of the study is to compare the efficacy of the different Valganciclovir dosing strategies in pediatric solid organ transplant recipients with…
2021 American Transplant Congress
Infection Rates in Heart Transplant Recipients With Combined Tacrolimus and Sirolimus at High versus Low Concentrations
S. Goyal, J. Lyons, J. Negrelli, M. Liebo, A. Heroux
Loyola University Medical Center, Maywood, IL
*Purpose: Assess the impact of tacrolimus-sirolimus (TAC/SRL) concentration on infection rate in heart transplant recipients (HTR).*Methods: A retrospective review of HTR on TAC/SRL for ≥…
2021 American Transplant Congress
Current Practices for Management and Treatment of COVID-19 in Immunocompromised Adults: A Survey of Institutions
H. H. Nam¹, S. Aslam², O. Beaird³, G. Forrest⁴, M. Fung⁵, A. Limaye⁶, A. Multani³, J. Nelson⁷, R. Rakita⁶, L. Strasfeld⁸, J. Schaenman³
¹Medicine, University of California - Irvine, Orange, CA, ²Division of Infectious Diseases and Global Public Health, University of California - San Diego, San Diego, CA, ³Medicine, University of California - Los Angeles, Los Angeles, CA, ⁴Medicine, Rush University, Chicago, IL, ⁵Medicine, University of California - San Francisco, San Francisco, CA, ⁶Medicine, University of Washington, Seattle, WA, ⁷Medicine, Stanford University, Palo Alto, CA, ⁸Medicine, Oregon Health and Science University, Portland, OR
*Purpose: The optimal testing strategy for solid organ transplantation (SOT) donor and recipient evaluation, as well as treatment for COVID-19 is unknown. We assessed the…