Am J Transplant, Volume 21, Suppl 3 Archives - Page 48 of 139 - ATC Abstracts

2021 American Transplant Congress
Regulatory Macrophage Induced by Il-33 Promoted Immune Tolerance of Kidney Transplantation Through Siglec-10
J. d. zhang, w. wang
Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
*Purpose: Acute and chronic rejection are key problems in renal transplantation. It is ideal to induce immune tolerance to suppress rejection while regulatory macrophages (Mregs)…
2021 American Transplant Congress
Triple-Knockout Pig Red Blood Cells Are a Potential Alternative Source for Clinical Blood Transfusion
T. Yamamoto¹, M. H. Bikhet¹, H. Q. Nguyen¹, M. Javed¹, D. Ayares², H. Iwase¹, H. Hara¹, D. K. Cooper¹
¹Xenotransplantation Program, Surgery, The University of Alabama at Birmingham, Birmingham, AL, ²Revivicor, Blacksburg, VA
*Purpose: Triple-knockout (TKO) pig RBCs (pRBCs) may be an alternative source for clinical blood transfusion because almost humans have no preformed antibody to TKO pRBCs.…
2021 American Transplant Congress
Composition of Ex Vivo Lung Perfusion Solutions and Kinetics Define Differential Cytokine and Chemokine Secretion in a Porcine Cardiac Arrest Model of Lung Preservation
L. M. Radomsky¹, A. Koch², C. Olbertz², J. F. Kuehne¹, Y. Liu², J. Keil¹, K. Beushausen¹, U. Rauen³, C. S. Falk¹, M. Kamler²
¹Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ²Thoracic Transplantation, Department of Thoracic and Cardiovascular Surgery, University Hospital Essen, Essen, Germany, ³Institute of Physiological Chemistry, University Hospital Essen, Essen, Germany
*Purpose: Ex vivo lung perfusion is an innovative technique to evaluate marginal lung organs especially after DCD. Normothermic continuous perfusion should reduce ischemic damage and…
2021 American Transplant Congress
Efficacy of Ex Vivo Normothermic Limb Perfusion in Maintaining Cellular Viability and Muscle Function
T. Xia¹, P. Sadeghi², V. Kopparthy², S. Pandey², A. Rampazzo², B. Bassiri Gharb²
¹School of Medicine, Case Western Reserve University, Cleveland, OH, ²Department of Plastic Surgery, Cleveland Clinic, Cleveland, OH
*Purpose: The purpose of this study was to evaluate cellular injury and myocyte function of amputated limbs following ex vivo normothermic limb perfusion (EVNLP) compared…
2021 American Transplant Congress
Should We Worry About Covid-19 Infection in Pediatric SOT?
U. Ekong¹, S. Paul¹, S. Royal², J. Chahine³, N. Yazigi¹, S. Kaufman¹, K. Khan¹, C. Matsumoto¹, A. Kroemer¹, T. Fishbein¹
¹Surgery, Medstar Georgetown Transplant Institute, Washington, DC, ²Pediatrics, Medstar Georgetown University Hospital, Washington, DC, ³Pathology and Laboratory Medicine, Medstar Georgetown University Hospital, Washington, DC
*Purpose: We describe the clinical presentation & immune response to COVID-19 infection in pediatric SOT.*Methods: Medical records of COVID-19 PCR+ or seropositive patients were reviewed…
2021 American Transplant Congress
Hla-dq Epitope Mismatch Predicts De Novo Donor-Specific Antibody Formation and Acute Cellular Rejection After Living Donor Liver Transplantation
K. Ono, K. Ide, Y. Tanaka, M. Ohira, H. Tahara, N. Tanimine, S. Akimoto, Y. Imaoka, K. Sato, H. Yamane, N. Tsukiyama, R. Ide, T. Mochizuki, H. Ohdan
Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health S, Hiroshima University, Hiroshima City, Japan
*Purpose: Epitope mismatch (MM) effect on living donor liver transplantation (LDLT) has not been studied in detail. This study aimed to investigate the role of…
2021 American Transplant Congress
Analysis of Single Cell RNA Sequencing Data to Define Biomarkers of Human Liver Immune Tolerance
B. Rocque¹, A. Barbetta¹, P. Singh¹, C. Goldbeck¹, D. G. Helou², E. Loh³, N. Ung⁴, J. S. Lee⁴, O. Akbari², J. Emamaullee¹
¹Surgery, University of Southern California Keck School of Medicine, Los Angeles, CA, ²Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA, ³Norris Medical Library, University of Southern California Keck School of Medicine, Los Angeles, CA, ⁴Ellison Institute, University of Southern California, Los Angeles, CA
*Purpose: The liver is unique in its ability to maintain immune homeostasis and promote operational tolerance following solid organ transplantation. Single-cell RNA sequencing (scRNA seq)…
2021 American Transplant Congress
Precision Medicine in Renal Transplantation: T-cell Repertoire Sequencing to Define Donor-specific Clones for Post-transplant Monitoring
K. R. Sherwood¹, P. Wong¹, F. Fenninger¹, V. Wu¹, J. Beckrud², D. P. Cina³, L. Allan², J. Lan², P. A. Keown²
¹University of British Columbia, Vancouver, BC, Canada, ²Vancouver General Hospital, Vancouver, BC, Canada, ³Urologic Sciences, Vancouver General Hospital, Vancouver, BC, Canada
*Purpose: Measuring donor-specific clonal responses offers a precise, sensitive and specific biomarker of immune recognition and activation. Combining deep immunophenotyping (DI) and T-cell receptor (TCR)…
2021 American Transplant Congress
Medical Costs in the Year Following Kidney Transplantation: Relationships with Renal Function and Graft Failure
M. Cooper¹, M. A. Schnitzler², C. Nilubol¹, W. Wang³, X. Zhu³, J. Wu³, R. J. Nordyke⁴
¹MedStar Georgetown Transplant Institute, Washington, DC, ²Saint Louis University, St. Louis, MO, ³Genesis Research, Hoboken, NJ, ⁴Angion Biomedica, San Francisco, CA
*Purpose: We describe relationships between total medical costs in the first year following kidney transplant with overall renal function as measured by: 1) estimated glomerular…
2021 American Transplant Congress
Outcomes of Lung Transplantation with Multi Drug Resistant Colonized Grafts, Retrospective Cohort Study in a Tertiary Care Hospital
N. Al-Ashi
Pharmacy, King Fahad Specialist Hospital -Dammam, Khobar, Saudi Arabia
*Purpose: Infections are the primary cause of morbidity and mortality after solid organ transplantation. Due to high incidence of lung graft colonization with multi drug…