2021 American Transplant Congress
Understanding Transplant Decision Making Concerns for African, Caribbean and Black Canadian Patients with End-Stage Kidney Disease
*Purpose: Compared to White Canadians, African, Caribbean and Black (ACB) Canadians with end stage kidney disease (ESKD) are less likely to receive a living donor…2021 American Transplant Congress
Belatacept and Carfilzomib-based Treatment of Active Antibody-mediated Rejection in a Sensitized Nonhuman Primate Model
*Purpose: One third of sensitized, HLA-incompatible transplant recipients experience antibody-mediated rejection (AMR) with limited effective treatment options. We tested a novel treatment strategy for AMR…2021 American Transplant Congress
Are Tacrolimus Concentrations Reduced with Direct-acting Antiviral Administration in Transplant Recipients?
Pharmacy, Penn State Health Hershey Medical Center, Hershey, PA
*Purpose: To evaluate the effects of direct-acting antivirals (DAAs) on tacrolimus trough concentrations and clinical outcome and to assess the need for a priori dose…2021 American Transplant Congress
Drones and Airplanes: Modeling the Potentially Deleterious Effects of Transportation on Shipped Organs
Surgery, University of Maryland, Baltimore, MD
*Purpose: During the first shipments of human organs by drone, we identified significant differences in pressure and vibration that may adversely affect shipped organs. Liver…2021 American Transplant Congress
Disparities in Living Donor Follow-up During the COVID-19 Emergency Suspension of OPTN Follow-up Reporting Requirements
*Purpose: The OPTN temporarily suspended follow-up reporting requirements on 4/3/20 (retroactive to 3/13/20) in response to the COVID-19 crisis. We assessed the policy’s impact on…2021 American Transplant Congress
Severe Hypoxemia After Liver Transplantation in the Hepatopulmonary Syndrome
Cleveland Clinic, Cleveland, OH
*Purpose: Hepato-pulmonary syndrome (HPS) is a complication of liver disease with liver transplantation as the only curative treatment. However these patients can develop severe hypoxemia…2021 American Transplant Congress
Tacrolimus Shortage and the Rush to Convert: An Unexpected Burden on the System During the Covid-19 Pandemic?
Medical University of South Carolina, Charleston, SC
*Purpose: A national shortage of immediate release (IR) tacrolimus (FK) fully impacted our center in May 2020. The conversion process was immediately challenging during the…2021 American Transplant Congress
Murine Cytomegalovirus Induces Kidney Allograft Injury via Th17 Cells Recruited by Both Viral Antigen-Specific and Cytokine/chemokine Mediated Pathways
*Purpose: Cytomegalovirus infection in transplant recipients has been associated with renal allograft rejection and graft failure. We have previously shown that murine CMV (MCMV) infected…2021 American Transplant Congress
Autoimmune Responses to DNA Topoisomerase I Exacerbate Renal Allograft Injury
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Multiple clinical and pre-clinical studies describe correlations between pre-existing or de novo autoimmune responses and poor transplant outcome. We have previously reported that following…2021 American Transplant Congress
The Hepatoprotective Role of Innate Lymphoid Cells in Liver Transplantation
The Dumont-UCLA Transplantation Center, Los Angeles, CA
*Purpose: Although NKp46+group 3innate lymphoid cells (ILCs) (RORγt+IL-22-producing NKp46+cells) were reported to protect liver against ischemia-reperfusion injury (IRI), no study has demonstrated the contribution of…
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