Am J Transplant, Volume 21, Suppl 3 Archives - Page 46 of 139 - ATC Abstracts

2021 American Transplant Congress
The Effect of Covid-19 on Offer Acceptance Rates by Age and Race Groups
A. Wey¹, J. Miller¹, Y. Ahn¹, D. Musgrove¹, A. Hart¹, N. Salkowski¹, M. Skeans¹, R. Hirose², A. Israni¹, J. Snyder¹, B. Kasiske¹
¹SRTR, Minneapolis, MN, ²Univ of San Fransico, San Francisco, CA
*Purpose: COVID-19 causes more severe complications in older patients and disproportionately leads to poor outcomes in racial minorities. High offer acceptance rates indicate better access…
2021 American Transplant Congress
Assessment of Donor-Derived Cell-Free DNA Performance Characteristics Across the Spectrum of TCMR and ABMR After Kidney Transplant
L. Bu¹, S. Anand², A. Pai³, J. S. Bromberg⁴, T. Alhamad⁵, V. Bowers⁶, I. Moinuddin⁷, S. Ghosh⁸, W. Tian⁸, E. Stites⁹, G. Gupta⁷
¹University of Minnesota, Minneapolis, MN, ²Intermountain Medical Center, Murray, UT, ³University of Texas McGovern Medical School, Houston, TX, ⁴University of Maryland School of Medicine, Baltimore, MD, ⁵Washington University in St. Louis, St. Louis, MO, ⁶Tampa General Hospital, Tampa, FL, ⁷Virginia Commonwealth University, Richmond, VA, ⁸CareDx, Brisbane, CA, ⁹University of Colorado, Aurora, CO
*Purpose: Different donor-derived cell-free DNA (dd-cfDNA) thresholds have been reported in association with varying TCMR, ABMR and “Borderline” diagnoses. Interpretation of dd-cfDNA levels spanning active…
2021 American Transplant Congress
Reducing Rejection in Pediatric Kidney Transplantation: The Improving Renal Outcomes Collaborative (iroc)
C. Varnell¹, A. Warmin¹, G. Barletta², C. Belsha³, L. Harshman⁴, D. Kershaw⁵, C. Pruette⁶, S. Ranabothu⁷, M. Seifert⁸, P. Singer⁹, M. Yanik¹⁰, K. Rich¹, A. Modi¹, D. Hooper¹
¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Phoenix Children’s Hospital, University of Arizona, Phoenix, AZ, ³SSM Health Cardinal Glennon Children's Hospital, St Louis, MO, ⁴University of Iowa Stead Family Children’s Hospital, Iowa City, IA, ⁵C.S. Mott Children’s Hospital, Ann Arbor, MI, ⁶Johns Hopkins University School of Medicine, Baltimore, MD, ⁷Arkansas Children’s Hospital, Little Rock, AR, ⁸University of Alabama at Birmingham, Children’s of Alabama, Birmingham, AL, ⁹Cohen Children's Hospital, Brooklyn, NY, ¹⁰Levine Children's Hospital, Charlotte, NC
*Purpose: To study the effect of implementing a Medication Adherence Promotion System (MAPS) on acute rejection (AR) rates in 9 pediatric kidney transplant (KT) programs.*Methods:…
2021 American Transplant Congress
Monoclonal Antibody Therapy for COVID-19 in Solid Organ Transplant Recipients
Z. A. Yetmar¹, E. Beam¹, J. C. O'Horo¹, R. Ganesh², D. M. Bierle², L. Brumble³, M. T. Seville⁴, R. R. Razonable¹
¹Infectious Diseases, Mayo Clinic, Rochester, MN, ²General Internal Medicine, Mayo Clinic, Rochester, MN, ³Infectious Diseases, Mayo Clinic, Jacksonville, FL, ⁴Infectious Diseases, Mayo Clinic, Scottsdale, AZ
*Purpose: Bamlanivimab and casirivimab-imdevimab are authorized for emergency use treatment of mild-to-moderate COVID-19 in patients at high-risk for progression to severe disease or hospitalization. For…
2021 American Transplant Congress
CEACAM1 Signaling is Essential to Elicit Tim-3 Inhibitory Regulation in Liver Transplantation
H. Kojima, H. Hirao, T. Ito, K. Kadono, K. J. Dery, F. M. Kaldas, J. W. Kupiec-Weglinski
The Dumont-UCLA Transplantation Center, Los Angeles, CA
*Purpose: T cell immunoglobulin domain and mucin domain-3 (TIM-3) has been reported to induce T cell exhaustion. By alleviating hepatic ischemia-reperfusion injury, we have explored…
2021 American Transplant Congress
The Clinical Validation of a Dried Blood Spot Method for Simultaneous Tacrolimus and Creatinine Measurement
M. I. Francke¹, S. Bouarfa², B. van Domburg², D. van de Velde², M. E. Hellemons³, O. C. Manintveld⁴, S. M. Last-Koopmans⁵, M. B. Mulder², D. A. Hesselink¹, B. C. de Winter²
¹Internal medicine, nephrology and transplantation, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ²Hospital Pharmacy, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ³Pulmonary medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁴Cardiology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁵Hematology, Erasmus MC, University Medical Center, Rotterdam, Netherlands
*Purpose: Monitoring tacrolimus concentrations and kidney function after transplantation is important to avoid tacrolimus under- and overexposure and its clinical consequences, including acute nephrotoxicity. Using…
2021 American Transplant Congress
The Confluence of Race, Socioeconomic Deprivation, and Waitlist Mortality for Children Awaiting Liver Transplant
S. Wadhwani¹, J. Ge¹, L. Gottlieb¹, C. Lyles¹, A. F. Beck², J. Bucuvalas³, U. Kotagal², J. C. Lai¹
¹University of California San Francisco, San Francisco, CA, ²Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Social determinants like racism, ethnocentrism, and neighborhood socioeconomic deprivation are associated with poor outcomes for children after liver transplant. We studied the relationship between…
2021 American Transplant Congress
Centre Variation in Emergency Hospital Readmissions Following Renal Transplantation in England
J. Peracha¹, D. Pitcher¹, R. Steenkamp¹, J. Medcalf², G. Lipkin³, D. Nitsch⁴, W. McKane⁵
¹UK Renal Registry, Bristol, United Kingdom, ²John Walls Renal Unit, Leicester General Hospital, Leicester, United Kingdom, ³University Hospitals Birmingham, Birmingham, United Kingdom, ⁴London School of Hygiene and Trpoical Medicine, London, United Kingdom, ⁵Sheffield Kidney Institute, Northern General Hospital, Sheffield, United Kingdom
*Purpose: Emergency hospital readmissions (EHR) following surgery are associated with significant patient distress, morbidity and costs to healthcare providers. In this study we aim to…
2021 American Transplant Congress
Feasibility of Normothermic Ex Vivo Kidney Perfusion for Human Kidney Transplantation: First North American Results
L. I. Mazilescu¹, P. Urbanellis¹, J. S. Kim¹, A. Konvalinka¹, T. W. Reichman¹, L. A. Robinson², A. Ghanekar¹, M. Selzner¹
¹Ajmera Transplant Program, Toronto General Hospital, Toronto, ON, Canada, ²Department of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: Normothermic ex vivo kidney perfusion is a novel preservation technique with promising results in porcine models and initial clinical results in one European center.…
2021 American Transplant Congress
Targeting Calcineurin/nfatc2 Signaling to Restore Pancreatic Beta-cell Function in Islet Transplantation
C. Darden¹, J. Mattke¹, S. Vasu¹, K. Kumano¹, Y. Liu¹, B. Naziruddin², M. C. Lawrence¹
¹Baylor University Medical Ctr, Dallas, TX, ²Baylor University Medical Ctr, Allen, TX
*Purpose: Pancreatic beta cells dedifferentiate upon exposure to metabolic and inflammatory stress characterized by loss of beta-cell identity genes, expression of beta-cell disallowed genes, and…