Am J Transplant, Volume 21, Suppl 3 Archives - Page 46 of 139 - ATC Abstracts

2021 American Transplant Congress
Comorbidity Burden is Associated with Increased Waitlist Mortality Among NASH Patients
J. R. Montgomery¹, M. J. Englesbe¹, C. Connelly²
¹Michigan Medicine, Ann Arbor, MI, ²General Surgery, Oregon Health & Science University, Portland, OR
*Purpose: Nonalcoholic steatotic hepatitis (NASH) is an increasing and common indication for liver transplantation. The association between increased comorbidity burden and risk of death on…
2021 American Transplant Congress
Contribution of T-bet Expressing CD27+ CD21- Activated Memory B Cells Poised for Plasma Cell Differentiation to Antibody-mediated Rejection of Kidney Transplants
K. Louis¹, E. Bailly¹, C. Macedo¹, B. Ramaswami¹, X. Gu¹, G. Chalasani¹, A. Zeevi¹, P. Randhawa¹, H. Singh², C. Lefaucheur³, D. Metes¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA, ²Center for Systems immunology, Department of Immunology, University of Pittsburgh, Pittsburgh, PA, ³Human Immunology and Immunopathology, INSERM U976, Paris, France
*Purpose: Alloimmunity triggered by donor-specific antibodies (DSAs) and ensuing development of antibody-mediated rejection (ABMR) are detrimental to organ transplants. Yet, the cellular states underlying B…
2021 American Transplant Congress
Duration and Magnitude of BK Viremia Do Not Predict Outcome in Patients After Kidney Transplantation
E. A. Farkash¹, J. T. Rajagopal², M. Vincent², M. D. Doshi³
¹Dept of Pathology, Michigan Medicine, Ann Arbor, MI, ²University of Michigan, Ann Arbor, MI, ³Dept of Nephrology, Michigan Medicine, Ann Arbor, MI
*Purpose: BK viremia was a major cause of kidney transplant failure in the early 2000’s and remains a risk factor for subsequent rejection. The standard…
2021 American Transplant Congress
Geospatial Analysis of Organ Procurement Organizations and Its Impact on Organ Donation Rates
D. Chyou¹, K. Ross-Driscoll², R. Lynch², D. S. Goldberg¹
¹University of Miami, Miami, FL, ²Emory University School of Medicine, Atlanta, GA
*Purpose: For the majority of organ procurement organizations (OPOs), OPO staff travel to donor hospitals to obtain consent and manage donors, while OPO headquarters (HQ)…
2021 American Transplant Congress
Immunologic Endotypes of Ischemia-reperfusion Injury in Human Liver Transplantation
R. A. Sosa, A. Q. Terry, F. M. Kaldas, B. V. Naini, T. Ito, R. W. Busuttil, D. W. Gjertson, J. W. Kupiec-Weglinski, E. F. Reed
UCLA, Los Angeles, CA
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for allograft rejection in orthotopic liver transplantation (OLT), involving complex interactions between innate and adaptive immune…
2021 American Transplant Congress
Digital Spatial Mrna Profiling Reveals Distinct Endothelial Transcripts in Dsa+ and Dsa- Endarteritis in Kidney Allografts
K. Tomaszewski¹, M. Araujo Medina¹, A. Bruce¹, P. Divakar², R. Smith¹, T. Kawai³, R. Colvin¹, I. Rosales¹
¹Department of Pathology, Massachusetts General Hospital, Boston, MA, ²NanoString Technologies, Inc., Seattle, WA, ³Department of Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: Renal allograft biopsy transcript analysis is typically performed by microarray, which lacks spatial resolution. We initiated a systematic program using the NanoString GeoMx® Digital…
2021 American Transplant Congress
Role of Ferroptosis Inhibitors in Mitigating Ischemia-Reperfusion Injury in Marginal Livers Using a Novel Protect Model
M. D. Nazzal, J. Van Nispen, A. Armstrong, V. Murali, E. Song, M. Voigt, A. Samaddar, E. Madsen, C. Manithody, J. Krebs, D. Blackall, D. Carpenter, C. Varma, J. Teckman, A. Jain
Saint Louis University, Saint Louis, MO
*Purpose: The discard rate of deceased donor livers (DDL) remains high at nearly 9% and incudes livers that are steatotic, old in age, and from…
2021 American Transplant Congress
Improving Policy-constrained Kidney Exchange via Pre-screening
D. C. McElfresh¹, M. Curry², S. Booker³, M. Stuart³, D. Stewart³, R. Leishman³, T. Sandholm⁴, J. Dickerson²
¹Applied Mathematics, University of Maryland, College Park, MD, ²University of Maryland, College Park, MD, ³United Network for Organ Sharing, Richmond, VA, ⁴Carnegie Mellon University, Pittsburgh, PA
*Purpose: Many planned kidney exchange transplants do not go to transplantation (they “fail”) for a variety of reasons, such as positive crossmatch and logistical difficulties.…
2021 American Transplant Congress
Early Transplant Education Increases CKD 3-5 Patients’ Knowledge and Informed Decision-Making About Chronic Kidney Disease and Living Donor Kidney Transplant
A. D. Waterman¹, S. H. Kawakita², B. Dub³, Y. A. Iraheta¹, A. L. Murillo², T. Menser⁴, B. Mittman³
¹UCLA David Geffen School of Medicine, Los Angeles, CA, ²Terasaki Institute, Los Angeles, CA, ³Research and Evaluation, Kaiser Permanente, Pasadena, CA, ⁴The Houston Methodist Research Institute, Houston, CA
*Purpose: Early education about chronic kidney disease (CKD) and living donor kidney transplant (LDKT) outside of transplant centers is inconsistent, with patients in CKD 3…
2021 American Transplant Congress
Impact of Allosensitization on Xenotransplantation
D. Olaso¹, M. Manook¹, J. Yoon¹, Y. Bae¹, A. Barbas¹, A. Adams², S. Knechtle¹, J. Kwun¹
¹Department of Surgery, Duke Transplantation Center, Durham, NC, ²Department of Surgery, University of Minnesota, Minneapolis, MN
*Purpose: Sensitization to human leukocyte antigens (HLA) due to prior exposure to foreign antigens through events such as blood transfusions, previous kidney transplant, or pregnancy…