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American Transplant Congress abstracts

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  • 2021 American Transplant Congress

    Evaluation of a Weight-Based Mycophenolate Mofetil Dosing Protocol for Kidney Transplant Maintenance Immunosuppression

    M. Mahoney1, E. Kincaide1, J. Nelson1, K. Klein1, R. Hall1, S. Bhayana2

    1University Health, San Antonio, Department of Pharmacotherapy and Pharmacy Services, The University of Texas at Austin, Pharmacotherapy Division, College of Pharmacy, San Antonio, TX, 2University Transplant Center, University Health, San Antonio, Department of Nephrology, The University of Texas Health Science Center at San Antonio, San Antonio, TX

    *Purpose: To evaluate the safety and efficacy of a weight-based mycophenolate mofetil (MMF) dosing protocol in adult kidney transplant recipients (KTR).*Methods: This single-center retrospective study…
  • 2021 American Transplant Congress

    The Pediatric National Liver Review Board: What Happens to Waitlist Registrations with Denied Exception Forms?

    J. Foutz1, C. Martinez1, A. Henderson1, E. K. Hsu2, E. R. Perito3, J. Heimbach4

    1United Network for Organ Sharing, Richmond, VA, 2Seattle Children's Hospital, Seattle, WA, 3UCSF, San Francisco, CA, 4Mayo Clinic, Rochester, MN

    *Purpose: On 5/14/19, the exceptions review process for pediatric liver transplant (LT) candidates was changed from 11 Regional Review Boards to one National Pediatric Liver…
  • 2021 American Transplant Congress

    Covid-19 Incidence Was Initially Associated with Posttransplant Kidney Graft Failure

    A. Wey1, J. Miller1, D. Musgrove1, N. Salkowski1, M. Tabaka1, R. Hirose2, A. Massie3, D. Segev3, A. Israni1, J. Snyder1, B. Kasiske1

    1SRTR, Minneapolis, MN, 2Univ of San Francisco, San Francisco, CA, 3Johns Hopkins, Baltimore, MD

    *Purpose: To better understand the effect of COVID-19 on kidney posttransplant outcomes, we estimated the association of county-level COVID-19 incidence with kidney posttransplant graft failure.*Methods:…
  • 2021 American Transplant Congress

    Associations of Mammalian Target of Rapamycin Inhibitors with Post-Transplant Malignancies and All-Cause Mortality: Cause-Specific Competing Risks and Composite Outcomes Analyses

    A. H. Santos1, E. Bueno1, M. A. Leghrouz1, W. Xuerong2

    1University of Florida, Gainesville, FL, 2University of Rhode Island, Kingston, RI

    *Purpose: We investigated the outcomes of malignancies and mortality associated with mammalian target of rapamycin inhibitor (MTORI) regimens in adult kidney transplant (KT) recipients (KTRs).*Methods:…
  • 2021 American Transplant Congress

    Nanoparticle Mediated Drug Delivery for Lung Transplantation

    P. M. Patel1, S. Jung2, C. L. Miller1, J. M. O1, T. Costa1, A. Dehnadi1, I. Hanekamp1, X. F. Li2, L. Jiang2, H. Ichimura2, A. Azimzadeh1, J. C. Madsen3, R. Abdi2

    1Surgery, Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, 2Medicine, Transplant Research Center, Brigham and Women's Hospital, Boston, MA, 3Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA

    *Purpose: Severe primary graft dysfunction (PGD) affects 30% of lung transplant patients. Pulmonary alveolar macrophages play a significant role in lung PGD, but systemic immunotherapy…
  • 2021 American Transplant Congress

    Prospective Intensive Monitoring for Anamnestic DSA Responses Allows Near Elimination of Early Clinical AMR

    M. McGowan1, A. Bickenbach1, A. R. Shields2, R. R. Alloway1, P. Brailey1, E. Portwood1, C. Alquist1, A. Christianson1, B. Abu Jawdeh1, M. Cuffy1, J. Kremer2, S. Bumb1, A. Govil1, M. Anand1, T. Kaur1, E. S. Woodle1

    1U Cincinnati, Cincinnati, OH, 2Christ Hospital, Cincinnati, OH

    *Purpose: Anamnestic donor specific antibody (aDSA) responses can result in severe, graft threatening antibody-mediated rejection (AMR). We hypothesized that intensive DSA monitoring (IDM) for aDSA…
  • 2021 American Transplant Congress

    High and Low Frequency Domino Liver Transplantation Centers Demonstrate Similar Outcomes

    J. Panichella, H. Resweber, H. Curtis, K. Nguyen, A. Di Carlo, S. Karhadkar

    Temple University School of Medicine, Philadelphia, PA

    *Purpose: For patients with transthyretin (TTR) Amyloidosis, the only disease modifying treatment is an orthotopic liver transplant. However, because of the nature of this disease,…
  • 2021 American Transplant Congress

    Cellular Landscape of Steatotic Livers Revealed by Single-nuclei Rna Sequencing

    C. Kuscu1, C. Kuscu1, A. Shetty2, E. Bardhi3, T. Rousselle4, J. Eason1, M. Sraj5, D. Maluf6, V. Mas4

    1Surgery, James D Eason Transplant Institute, Memphis, TN, 2University of Maryland, Institute for Genome Sciences, Baltimore, MD, 3Program in Transplantation - University of Maryland, Baltimore, MD, 4Surgery, Division of Surgical Science, Baltimore, MD, 5Surgery, University of Maryland, Baltimore, MD, 6Surgery, Program in Transplantation - University of Maryland, Baltimore, MD

    *Purpose: Hepatic IRI represents a barrier to the use of available organs for transplant, particularly fatty livers. We aimed to discern the cellular subsets and…
  • 2021 American Transplant Congress

    Launching a National Living Donor Registry

    J. E. Milton1, M. Cooper2, B. Hippen3

    1Transplant Center, University of Texas Health San Antonio, San Antonio, TX, 2MedStar Georgetown Transplant Institute, Washington, Colombia, 3Metrolina Nephrology Associates, PA, Charlotte, NC

    *Purpose: The National Donate Life Living Donor Registry launching in 2021 will allow 4000 persons a day the opportunity to become a living donor offering…
  • 2021 American Transplant Congress

    Frequency and Types of Pharmacist Interventions and Risk Assessments Occurring During the 12-Month Transafe Rx Randomized Controlled Trial

    H. M. Gonzales, J. N. Fleming, D. J. Taber

    MUSC, Charleston, SC

    *Purpose: Clinical pharmacists have unique education and training to identify and mitigate medication (med) safety issues in high-risk populations, such as kidney transplant (KTX). The…
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