Am J Transplant, Volume 21, Suppl 3 Archives - Page 3 of 139 - ATC Abstracts

2021 American Transplant Congress
Life-supporting Multi-gene Cardiac Xenografts From Swine Demonstrate Survival >8 Months and Preclinical Efficacy for Human Clinical Trials
C. Goerlich¹, B. Griffith¹, A. Singh¹, T. Zhang¹, I. Tatarov¹, B. Lewis¹, F. Sentz¹, A. Hershfeld¹, P. Odonkor¹, B. Williams¹, E. Strauss¹, A. Tabatabai², A. Bhutta³, D. Ayares⁴, D. Kaczorowski¹, M. Mohiuddin¹
¹Surgery, University of Maryland School of Medicine, Baltimore, MD, ²Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD, ³Pediatrics, Pediatric Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD, ⁴Revivicor, Inc., Blacksburg, VA
*Purpose: Cardiac xenotransplantation has been proposed to bridge the gap in organ shortage for those in end-stage heart failure without the opportunity to receive a…
2021 American Transplant Congress
Short-term Therapy with Anti-icam-1 Monoclonal Antibody Induced Long-term Liver Allograft Survival in Non-human Primates
S. Hong¹, D. Han², S. Lee², J. Kim³, E. Hwang³, H. Kim⁴, J. Lee⁵, K. Hong¹, E. Han¹, J. Cho¹, J. Lee¹, Y. Choi¹, K. Lee¹, N. Yi¹, J. Yang¹, K. Suh¹
¹Surgery, Seoul National University College of Medicine, Seoul, Korea, Republic of, ²Biomedical Research Institute, Seoul National University College of Medicine, Seoul, Korea, Republic of, ³Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Korea, Republic of, ⁴Pathology, Seoul National University College of Medicine, Seoul, Korea, Republic of, ⁵Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of
*Purpose: Tolerance induction remains challenging following liver transplantation and the long-term use of immunosuppressants, especially calcineurin inhibitors, leads to serious complications. We aimed to test…
2021 American Transplant Congress
Extreme Phenotype Sampling and Next Generation Sequencing to Identify Genetic Variants Associated with Tacrolimus Metabolism in African American Kidney Transplant Recipients
C. R. Dorr¹, B. Guo², B. Wu², J. Abrahante², D. Schladt³, R. Remmel², W. Guan², A. Muthusamy³, G. Onyeaghala³, N. Pankratz², A. Matas², R. Mannon⁴, W. Oetting², P. Jacobson², A. K. Israni³
¹Hennepin Healthcare Research Institute, Minneapolis, MN, ²University of Minnesota, Minneapolis, MN, ³Nephrology, Hennepin Healthcare Research Institute, Minneapolis, MN, ⁴University of Nebraska Medical Center, Omaha, NE
*Purpose: Tacrolimus (TAC) pharmacogenomics studies identified common genetic variants that alter TAC troughs suggesting strategic dosing for specific populations. Common variants and clinical factors explain…
2021 American Transplant Congress
A Machine Learning-Based Predictive Model for Outcome of Covid-19 in Kidney Transplant Recipients
I. Revuelta¹, F. Santos-Arteaga², D. Di Caprio³, E. Montagud-Marrahi¹, F. Cofan¹, J. Torregrosa¹, M. Bodro⁴, A. Moreno⁴, P. Ventura-Aguiar¹, D. Cucchiari¹, N. Esforzado¹, G. Piñeiro¹, J. Ugalde-Altamirano¹, J. Campistol¹, A. Alcaraz⁵, B. Bayès¹, E. Poch¹, F. Oppenheimer¹, F. Diekmann¹
¹Department of Nephrology and Kidney Transplant, Hospital Clinic, Barcelona, Spain, ²Faculty of Economics and Management, Free University of Bolzano, Bolzano, Italy, ³Department of Economics and Management, University of Trento, Trento, Italy, ⁴Department of Infectious Diseases, Hospital Clinic, Barcelona, Spain, ⁵Department of Urology, Hospital Clinic, Barcelona, Spain
*Purpose: Health systems need tools to deal with COVID-19, especially for high-risk population,such as transplant recipients. Predictive models are necessary to improve management of patients…
2021 American Transplant Congress
Challenges and Stressors of COVID-19 Kidney and Transplant Patients: A Mixed Methods Study
Y. A. Iraheta¹, A. L. Murillo², E. H. Wood¹, S. M. Advani³, R. Pines⁴, A. D. Waterman¹
¹UCLA David Geffen School of Medicine, Los Angeles, CA, ²Terasaki Institute, Los Angeles, CA, ³National Human Genome Research Institute (NIH), Bethesda, MD, ⁴Santa Barbara Cottage Hospital, Santa Barbara, CA
*Purpose: To assess the unique needs of at-risk kidney and transplant patients and their caregivers during COVID-19, we established a telephone Listening Center enabling them…
2021 American Transplant Congress
Successful Long-Term TMA- and Rejection-Free Survival of a Kidney Xenograft With Triple Xenoantigen Knockout Plus Insertion of Multiple Human Transgenes
T. Hirose¹, D. Ma¹, G. Lassiter¹, H. Sasaki¹, I. Rosales², T. Coe¹, C. Rickert¹, R. Matheson¹, R. Colvin², W. Qin³, Y. Kan³, J. Layer³, K. Stiede³, K. Hall³, M. Youd³, W. Westlin³, M. Curtis³, J. F. Markmann¹, T. Kawai¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Pathology, Massachusetts General Hospital, Boston, MA, ³eGenesis Inc, Cambridge, MA
*Purpose: Pigs with deletion of 3 carbohydrate xenoantigens (triple knock-out, TKO) are expected to be optimal donors for human xenotransplantation. However, anti-porcine natural antibodies of…
2021 American Transplant Congress
Transplanting Hepatitis C Infected Organs Into Uninfected Recipients: A Pharmacy Perspective
M. L. Holt, A. James, K. Gutierrez, T. Sparkman, J. Banbury, D. Jones
University of Alabama at Birmingham Hospital, Birmingham, AL
*Purpose: Due to direct acting antivirals (DAAs), hepatitis C virus (HCV) positive patients are now resources for organ transplantation in HCV negative recipients. Our institution…
2021 American Transplant Congress
Does the NSQIP-Transplant Experience Demonstrate That Obese Kidney Transplant Recipients are Still at Increased Risk for Surgical Site Infections?
H. C. Yaffe¹, A. K. Belli¹, J. R. Parekh², D. L. Sudan³, N. Elias⁴, K. D. Conzen⁵, D. P. Foley⁶, R. Hirose⁷, S. M. Greenstein¹
¹Surgery, Montefiore-Einstein Center for Transplantation, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, ²Surgery, University of California San Diego, San Diego, CA, ³Surgery, Division of Abdominal Transplant Surgery, Duke University Medical Center, Durham, NC, ⁴Surgery, Transplant Surgery Division, Massachusetts General Hospital, Boston, MA, ⁵Surgery, Division of Transplant Surgery, University of Colorado Hospital, Aurora, CO, ⁶Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, ⁷Surgery, University of California San Francisco, San Francisco, CA
*Purpose: The National Surgical Quality Improvement Program for Transplant (NSQIP-T) was designed to track surgical outcomes in adult liver and kidney transplants (KTX). The Pilot…
2021 American Transplant Congress
Predicted Heart Mass Difference as a Risk Factor for Severe Primary Graft Dysfunction in the Contemporary Era of Heart Transplantation: A Report from the International Consortium on Primary Graft Dysfunction
F. Foroutan¹, L. K. Truby², Y. Moayedi¹, J. Han³, J. Guzman⁴, M. Farrero⁴, E. Baughan⁵, M. Farr⁵, H. Zafar⁶, J. Felius⁶, J. van Zyl⁷, D. Law⁸, S. Chih⁸, P. Angleitner⁹, M. Sabatino¹⁰, A. DeVore², R. J. Miller¹¹, L. Potena¹⁰, A. Zuckermann⁹, K. K. Khush³, S. A. Hall⁶, H. J. Ross¹
¹Ted Rogers Centre for Heart Research, Toronto, ON, Canada, ²Duke University School of Medicine, Durham, NC, ³Stanford University, Stanford, CA, ⁴Clinic Barcelona Hospital Universitari, Barcelona, Spain, ⁵Columbia University Medical Center, New York, NY, ⁶Baylor University Medical Center, Dallas, TX, ⁷Dallas University Medical Center, Dallas, TX, ⁸University of Ottawa Heart Institute, Ottawa, ON, Canada, ⁹Medical University of Vienna, Vienna, Austria, ¹⁰Bologna University Hospital, Bologna, Italy, ¹¹University of Calgary, Calgary, AB, Canada
*Purpose: Primary Graft Dysfunction (PGD) increases early mortality after heart transplant (HT). Predicted heart mass (PHM) difference may be a risk factor for PGD. Lack…
2021 American Transplant Congress
The Intersection of Cost, Quality, and Volume in Liver Transplant
D. Axelrod¹, R. Balakrishnan¹, A. Harris², S. Hohmann², J. Snyder³, B. Kasiske³, M. Schnitzler⁴, K. Lentine⁴
¹Univ of Iowa, Iowa City, IA, ²Vizient Inc., Irving, TX, ³SRTR, Minneapolis, MN, ⁴Saint Louis Univ, Saint Louis, MO
*Purpose: As a consequence of changing allocation practices and the ongoing shortage of high-quality organs, the cost of liver transplant (LT) continues to increase throughout…