Am J Transplant, Volume 21, Suppl 3 Archives - Page 2 of 139 - ATC Abstracts

2021 American Transplant Congress
Machine Perfusion of Kidney Grafts in Simultaneous Liver Kidney Transplantation: National Trends and Outcomes
A. Chang¹, M. Chen¹, P. Abt¹, T. Bittermann²
¹Surgery, University of Pennsylvania, Philadelphia, PA, ²Gastroenterology, University of Pennsylvania, Philadelphia, PA
*Purpose: In this study we analyze the SRTR liver data set to determine the trends in machine perfusion of kidney grafts prior to SLK and…
2021 American Transplant Congress
ABCC2 Haplotypes Associations to Mycophenolic Acid Pharmacokinetics in Stable Renal Transplant Recipients
K. Tornatore¹, D. Brazeau², C. Meaney³, J. Consiglio⁴, A. Gundroo⁵, S. Chang⁶, G. Wilding⁴, L. Cooper³
¹Pharmacy Practice, School of Pharmacy; University at Buffalo- SUNY, Buffalo, NY, ²Pharmacy Practice, Marshall University, Huntington, WV, ³Pharmacy Practice, School of Pharmacy; University at Buffalo, Buffalo, NY, ⁴Biostatistics, School of Public Health; University at Buffalo, Buffalo, NY, ⁵Medicine, School of Medicine; Ohio State University, Columbus, OH, ⁶Medicine, School of Medicine; University at Buffalo, Buffalo, NY
*Purpose: Mycophenolic acid (MPA), exhibits interpatient pharmacokinetic (PK) variability attributed to enterohepatic circulation of the glucuronide metabolite (MPAG) to MPA. This is mediated by multidrug…
2021 American Transplant Congress
Kidney Paired Exchange in Children in the United-states
J. Hogan¹, A. G. Thomas², J. Verbesey³, D. L. Segev⁴
¹Transplant Research Center, Department of Surgery, Emory University, Atlanta, GA, ²Department of Epidemiology, University of North Carolina, Chapel Hill, NC, ³Department of Surgery, Medstar Georgetown Transplant Institute, Washington, DC, ⁴Department of Surgery, Johns Hopkins University, Baltimore, MD
*Purpose: Kidney paired exchange (KPE) plays an increasing role in the landscape of adult living donor transplant (LDTx) in the US. LDTx is the treatment…
2021 American Transplant Congress
Impact of Graft Quality on Patient Survival in Sick Patients
G. Handing¹, S. Keeling¹, C. Christmann¹, N. Galvan², C. O’Mahony², J. Goss², R. Cotton², A. Rana²
¹School of Medicine, Baylor College of Medicine, Houston, TX, ²Michael E DeBakey Department of Surgery, Division of Abdominal Transplant, Houston, TX
*Purpose: It is widely accepted in the literature that patients who have a Model for End Stage Liver Disease (MELD) Score greater than 30 incur…
2021 American Transplant Congress
Higher Number of Tacrolimus Dose Adjustments and Trough Level Measurements in Kidney Transplant Recipients with CYP3A5*1 Alleles
K. Reininger¹, G. Onyeaghala², T. Anderson-Haag¹, B. Wu², W. Guan², C. R. Dorr², R. Remmel², R. Mannon³, A. Matas², W. Oetting², A. Israni¹, P. Stahler¹, P. Jacobson²
¹Hennepin County Medical Center, Minneapolis, MN, ²University of Minnesota, Minneapolis, MN, ³University of Nebraska Medical Center, Omaha, NE
*Purpose: Tacrolimus (TAC) metabolism is dependent on the functional status of the cytochrome P450 family enzyme CYP3A5 which has three common loss of function (LoF)…
2021 American Transplant Congress
Basiliximab versus Alemtuzumab: The Association Between Induction Agent and Airway Complications Following Lung Transplantation
M. Furukawa¹, E. G. Chan¹, T. Harano¹, J. Ryan¹, R. Rivosecchi², M. R. Morrell¹, P. G. Sanchez¹
¹Cardiothoracic Surgery, UPMC, Pittsburgh, PA, ²PUH-Pharmacy, UPMC, Pittsburgh, PA
*Purpose: Controversy still exist regarding the best induction strategy for lung transplantation. At our institution, induction is defined based on donor recipient CMV match. While…
2021 American Transplant Congress
Marginal Zone B Cells Support Donor-Specific Alloantibody Responses to Heart Allografts
V. Gorbacheva, R. Fan, W. Baldwin, R. Fairchild, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Production of high affinity isotype-switched donor specific alloantibodies (DSA) after transplantation is associated with germinal center formation by follicular (FO) B cells whereas the…
2021 American Transplant Congress
Cytomegalovirus (CMV) D+/R- Serostatus is Independently Associated with Mortality and Graft Loss After Liver Transplantation (LTx)
P. Vutien, J. Perkins, S. Biggins, J. Reyes, A. Limaye
Internal Medicine, University of Washington Medical Center, Seattle, WA
*Purpose: It is unknown if donor or recipient (D/R) CMV serostatus, in the era of CMV prophylactic and pre-emptive strategies, remains associated with clinical outcomes…
2021 American Transplant Congress
Relationship of Functional Frailty and Radiographic Sarcopenia to Outcomes After Liver Transplant
S. L. Olson, P. Polineni, W. Schwartz, O. Siddiqui, L. Zhao, D. Ganger, D. P. Ladner
Comprehensive Transplant Center, Northwestern University, Chicago, IL
*Purpose: Frailty and sarcopenia are associated with increased risk of hospitalization and mortality in end stage liver disease patients. Frailty can be measured clinically using…
2021 American Transplant Congress
P40 Homodimers Induce Il-15 to Promote Endogenous Donor-reactive Memory Cd8 T Cell Activation within High-risk Cardiac Allografts
H. Tsuda, A. Valujskikh, R. Fairchild
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Longer cold ischemic storage (CIS) time prior to transplant results in increased proliferation of endogenous donor-reactive memory CD8 T cells within complete MHC-mismatched cardiac…