Am J Transplant, Volume 21, Suppl 3 Archives - Page 2 of 139 - ATC Abstracts

2021 American Transplant Congress
Impact of Statin Intensity on the Incidence of Vascular Events and Graft Survival in Heart Transplant Recipients
E. Kim¹, I. Booth², R. Madathil³, B. Ravichandran¹, M. Demehin², M. Plazak²
¹University of Maryland School of Pharmacy, Baltimore, MD, ²Pharmacy, University of Maryland Medical Center, Baltimore, MD, ³University of Maryland School of Medicine, Baltimore, MD
*Purpose: Cardiac allograft vasculopathy (CAV) limits long-term graft survival of heart transplant (HT) recipients. In addition to decreased synthesis of cholesterol, statins also demonstrate immunomodulatory…
2021 American Transplant Congress
Optimal Antimicrobial Duration for Donor Positive Cultures in Kidney Transplant Recipients
J. Ferrante, K. Schnelle, M. Palettas, S. Sarwar, H. Winters, M. Chunduru
Pharmacy, The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: Utilization of organs from infected donors carries the risk of transmission of the donor organism to the recipient. While antimicrobials are recommended in recipients…
2021 American Transplant Congress
Worsening Impact of Acute Kidney Rejection on Long Term Graft Survival from 2000 to 2014
D. Leeser¹, W. Irish¹, K. Ravindra², V. Villani², A. Connor², J. Tuttle¹
¹Surgery, East Carolina University, Greenville, NC, ²Surgery, Duke University, Durham, NC
*Purpose: Acute rejection (AR) has been shown to impact graft survival after kidney transplant (KTx), however there is limited data on its impact on long…
2021 American Transplant Congress
Impact Analysis of Virtual Transplant Ambulatory Pharmacist During Covid-19
L. Park, G. Waldman, J. Kim, C. Rogers, J. Clark
Massachusetts General Hospital, Boston, MA
*Purpose: During the COVID-19 pandemic, transplant centers were challenged to meet the demand for new telemedicine strategies. High-risk immunocompromised patients, such as lung transplant recipients…
2021 American Transplant Congress
Response to a Pandemic: The Fall and Rise of Kidney Transplantation in the US
S. Bisen¹, B. Boyarsky¹, W. Werbel¹, J. Snyder², J. Garonzik-Wang¹, D. Segev¹, A. Massie¹
¹JHU, Baltimore, MD, ²SRTR, Minneapolis, MN
*Purpose: During the first wave of the COVID-19 epidemic in March-April 2020, waitlist registrations and living/deceased donor kidney transplants (LDKT/DDKT) dropped substantially. A second wave…
2021 American Transplant Congress
The Initial Impact of Covid-19 on Reported Graft Failure Rates and Potential Confounding of Srtr Psrs
A. Wey¹, J. Miller¹, D. Musgrove¹, Y. Ahn¹, M. Valapour², N. Salkowski¹, M. Skeans¹, A. Massie³, R. Hirose⁴, D. Segev³, A. Israni¹, J. Snyder¹, B. Kasiske¹
¹SRTR, Minneapolis, MN, ²Cleveland Clinic, Cleveland, OH, ³Johns Hopkins, Baltimore, MD, ⁴Univ of California, San Francisco, San Francisco, CA
*Purpose: COVID-19 could bias the Scientific Registry of Transplant Recipients (SRTR) program-specific reports (PSRs), especially if its impact varied geographically.*Methods: Recipients who received transplants from…
2021 American Transplant Congress
High Levels of Donor-Derived Cell-Free DNA Predict EGFR Decline After Kidney Transplantation
T. Alhamad¹, V. Bowers², E. Stites³, S. Anand⁴, J. S. Bromberg⁵, H. Murad¹, G. Gupta⁶, I. Moinuddin⁶, L. Bu⁷, S. Ghosh⁸, J. Zeng⁸, A. Pai⁹
¹Washington University in St. Louis, St. Louis, MO, ²Tampa General Hospital, Tampa, FL, ³University of Colorado, Aurora, CO, ⁴Intermountain Medical Center, Murray, UT, ⁵University of Maryland School of Medicine, Baltimore, MD, ⁶Virginia Commonwealth University, Richmond, VA, ⁷University of Minnesota, Minneapolis, MN, ⁸CareDx, Brisbane, CA, ⁹University of Texas McGovern Medical School, Houston, TX
*Purpose: Persistent, low-grade inflammation is associated with decline in eGFR. Cross-sectional studies have demonstrated a consistent association between circulating inflammatory markers and kidney function. Our…
2021 American Transplant Congress
The Effect of the Different Donor-Derived HLA T-Cell Epitope Targets on the Development of T Cell-Mediated Rejection After Kidney Transplantation
A. Senev, E. Van Loon, M. Emonds, M. Naesens
Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
*Purpose: Many kidney allografts fail due to rejections caused by the donor and recipient HLA incompatibility. Recent studies have shown that HLA-DR and DQ mismatches…
2021 American Transplant Congress
A Mechanistic Evaluation to Guide the Optimal Immunosuppression Adjustment Strategy in Transplant Patients with COVID-19
V. Hall, V. Ferreira, D. Kumar, A. Humar
UHN, Toronto, ON, Canada
*Purpose: The optimal management of immunosuppression in transplant patients infected with COVID-19 is unknown. Reduction in calcineurin inhibitors or antimetabolite doses is often performed in…
2021 American Transplant Congress
LTβR Engagement Regulates Treg Migration, Stability and Suppressor Function
V. Saxena¹, W. Piao¹, L. Li¹, Y. Xiong¹, M. W. Shirkey¹, J. Iyyathurai¹, R. Lakhan¹, R. Abdi², J. Bromberg¹
¹U Maryland, Baltimore, MD, ²Harvard U, Boston, MA
*Purpose: Regulatory T cell (Treg) lymphatic migration and maintenance of transcription factor Foxp3 expression are required for suppressor function and allograft protection. Treg stimulate lymphotoxin…