Am J Transplant, Volume 21, Suppl 3 Archives - Page 18 of 139 - ATC Abstracts

2021 American Transplant Congress
Geospatial Analysis of Organ Procurement Organizations and Its Impact on Organ Donation Rates
D. Chyou¹, K. Ross-Driscoll², R. Lynch², D. S. Goldberg¹
¹University of Miami, Miami, FL, ²Emory University School of Medicine, Atlanta, GA
*Purpose: For the majority of organ procurement organizations (OPOs), OPO staff travel to donor hospitals to obtain consent and manage donors, while OPO headquarters (HQ)…
2021 American Transplant Congress
Immunologic Endotypes of Ischemia-reperfusion Injury in Human Liver Transplantation
R. A. Sosa, A. Q. Terry, F. M. Kaldas, B. V. Naini, T. Ito, R. W. Busuttil, D. W. Gjertson, J. W. Kupiec-Weglinski, E. F. Reed
UCLA, Los Angeles, CA
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for allograft rejection in orthotopic liver transplantation (OLT), involving complex interactions between innate and adaptive immune…
2021 American Transplant Congress
Digital Spatial Mrna Profiling Reveals Distinct Endothelial Transcripts in Dsa+ and Dsa- Endarteritis in Kidney Allografts
K. Tomaszewski¹, M. Araujo Medina¹, A. Bruce¹, P. Divakar², R. Smith¹, T. Kawai³, R. Colvin¹, I. Rosales¹
¹Department of Pathology, Massachusetts General Hospital, Boston, MA, ²NanoString Technologies, Inc., Seattle, WA, ³Department of Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: Renal allograft biopsy transcript analysis is typically performed by microarray, which lacks spatial resolution. We initiated a systematic program using the NanoString GeoMx® Digital…
2021 American Transplant Congress
Role of Ferroptosis Inhibitors in Mitigating Ischemia-Reperfusion Injury in Marginal Livers Using a Novel Protect Model
M. D. Nazzal, J. Van Nispen, A. Armstrong, V. Murali, E. Song, M. Voigt, A. Samaddar, E. Madsen, C. Manithody, J. Krebs, D. Blackall, D. Carpenter, C. Varma, J. Teckman, A. Jain
Saint Louis University, Saint Louis, MO
*Purpose: The discard rate of deceased donor livers (DDL) remains high at nearly 9% and incudes livers that are steatotic, old in age, and from…
2021 American Transplant Congress
DSA Causes Mild Molecular ABMR-like Changes in Many Biopsies Not Diagnosed as Rejection
P. F. Halloran¹, K. S. Madill-Thomsen¹, &. the INTERCOMEX Study Group²
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²., ., AB, Canada
*Purpose: In the multicenter study INTERCOMEX, we developed a microarray-based system (MMDx) for diagnosing antibody-mediated and T cell-mediated rejection (ABMR, TCMR) in kidney transplant biopsies…
2021 American Transplant Congress
A Meta-Analysis of Endoscopic Stents in the Treatment of Anastomotic Biliary Strictures After Liver Transplantation
F. Zhou¹, M. Mieth¹, C. Rupp², A. Mehrabi¹, A. Nickkholgh¹
¹Department of General, Abdominal and Transplant Surgery, University of Heidelberg, Heidelberg, Germany, ²Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany
*Purpose: Biliary strictures (BS) are common after orthotopic liver transplantation (OLT). The treatment of choice is endoscopic retrograde cholangiopancreatography (ERCP). Multiple plastic stents (MPS) have…
2021 American Transplant Congress
Beneficial Effects of Argon Inhalation on Reducing Lung Ischemia-reperfusion Injury in Miniature Swine
H. Sahara
Div. Organ Replacement and Xeno Tx, Center for Advanced Biomedical Science and Swine Research, Kagoshima University, Kagoshima, Japan
*Purpose: Noble gases, such as xenon and argon (Ar), are chemically inert but have shown to have cytoprotective effect. In contrast to xenon, Ar is…
2021 American Transplant Congress
Long Term Outcomes of Kidney Donors with Fibromuscular Dysplasia
H. N. Adrogue¹, A. Evans¹, S. A. Hebert¹, H. E. Adrogue¹, D. T. Nguyen², D. Murad¹, E. A. Graviss²
¹Medicine, Houston Methodist Hospital, Houston, TX, ²Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX
*Purpose: Fibromuscular dysplasia (FMD) is not an infrequent finding during kidney donor evaluation. Current guidelines do not provide any recommendations regarding the use of kidneys…
2021 American Transplant Congress
Economic Impact of a Pharmacist-Led Medication Safety Intervention: Report from the Transafe Rx Randomized Controlled Trial
D. Taber, J. Fleming, Z. Su, P. Mauldin, M. Gebregziabher
Med Univ of South Carolina, Charleston, SC
*Purpose: We have previously demonstrated the efficacy of a pharmacist-led, mHealth intervention on reducing medication errors and adverse events leading to reduce hospitalizations in kidney…
2021 American Transplant Congress
Complement Blockade Improves Renal Xenograft Survival in Primates in the Absence of Transgenic Complement Regulatory Proteins
D. A. Faber¹, B. Lovasik¹, A. Matar¹, C. Breeden¹, A. B. Farris², M. Tector³, A. Tector³, A. Adams⁴
¹Surgery, Emory University School of Medicine, Atlanta, GA, ²Pathology, Emory University School of Medicine, Atlanta, GA, ³Surgery, University of Miami, Miami, FL, ⁴Surgery, University of Minnesota, Minneapolis, MN
*Purpose: Complement activation is a major contributor to xenograft rejection. To minimize xenograft injury, complement suppression via insertion of human complement-regulatory transgenes into the donor…