ATC Abstracts

American Transplant Congress abstracts

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  • 2021 American Transplant Congress

    Superior Post-transplant Clinical Outcomes Using Portable Normothermic Perfusion and Assessment with the Organ Care System (ocs) Liver System: 1-year Outcomes of the Ocs Liver Protect Randomized Controlled Trial

    J. Markmann1, M. Abouljoud2, M. Ghobrial3, C. Bhati4, S. Pelletier5, J. Magliocca6, T. Pruett7, A. Lu8, M. Rizzari9, S. Ottmann10, T. Klair11, C. Eymard12, G. Roll13, G. Reyes14, S. Black15, S. Florman16, S. Mirani17, C. Marsh18, G. Schnickel19, M. Kinkhabwala20, A. Demetris21, H. Yeh22, P. Vagefi23, M. MacConmara23

    1MGH, Boston, MA, 2Henry Ford, Detroit, MI, 3Houston Methodist, Houston, TX, 4Virginia Commonwealth, Richmond, VA, 5UVA, Charlottesville, VA, 6Emory, Atlanta, GA, 7U. Minnesota, Minneapolis, MN, 8Tampa General, Tampa, FL, 9Henry Ford, Detriot, MI, 10Johns Hopkins, Baltimore, MD, 11University of Texas HSC, San Antonio, TX, 12University of Tennessee HSC, Memphis, TN, 13UCSF, San Francisco, CA, 14U. Washington, Seattle, WA, 15Ohio State, Columbus, OH, 16Mt. Sinai, New York, NY, 17U. Nebraska, Omaha, NE, 18Scripps Clinic, San Diego, CA, 19U. San Diego, San Diego, CA, 20Montefiore, New York, MA, 21UPMC, Pittsburgh, PA, 22Massachusetts General Hospital, Boston, MA, 23UT Southwestern, Dallas, TX

    *Purpose: The OCS Liver PROTECT Trial was the first U.S. randomized controlled trial for liver perfusion and was designed to evaluate the impact of portable…
  • 2021 American Transplant Congress

    Prediction of Renal Allograft Tolerance by Machine Learning

    Q. Fu1, K. Deng2, H. Yang1, S. Deng1, J. F. Markmann2

    1Organ Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Sciences and Technology of China, Chengdu, China, 2Center for Transplantation Sciences, MGH, Boston, MA

    *Purpose: An ideal goal of transplantation is to withdraw or minimize immunosuppressants via the induction of tolerance to overcome drug toxicity, prolong allograft survival, and…
  • 2021 American Transplant Congress

    Depressive Symptoms and Listing for Kidney Transplantation

    X. Chen, N. Chu, P. Sharma Basyal, W. Vihokrut, D. Crews, D. Brennan, S. Andrews, T. Vannorsdall, D. Segev, M. McAdams DeMarco

    Johns Hopkins University School of Medicine, Baltimore, MD

    *Purpose: Among patients with kidney failure, depressive symptoms are common and may be a barrier to completing the complex process of kidney transplantation (KT) evaluation…
  • 2021 American Transplant Congress

    Alpha 1-antitrypsin Reduces Cytokine Elaboration in a Xenogeneic Lung Transplantation Model

    L. Burdorf1, C. Laird2, T. Zhang2, M. R. Connolly1, Z. Habibabady1, S. Pratts1, S. Miura1, F. Pollok1, W. Eyestone3, C. J. Phelps3, D. L. Ayares3, A. M. Azimzadeh1, R. N. Pierson III1

    1Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Surgery, University of Maryland, Baltimore, MD, 3Revivicor, Blacksburg, VA

    *Purpose: Novel gene editing techniques have facilitated the generation of donor pigs with multiple genetic modifications, used for xenolung transplantation. Several rejection pathways, including antibody…
  • 2021 American Transplant Congress

    Outcomes of Kidney Transplantation from Hepatitis C Virus (HCV) Infected Donors Stratified by Recipient HCV Serostatus: A Mate Kidney Analysis

    K. K. Sureshkumar1, B. Chopra1, R. L. McGill2

    1Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, PA, 2Nephrology, University of Chicago, Chicago, IL

    *Purpose: Kidneys from donors infected with hepatitis C virus (HCV) are increasingly used for transplantation into HCV positive (+) recipients historically and into HCV negative…
  • 2021 American Transplant Congress

    Primary Uretero-ureterostomy in Renal Transplantation

    H. Shokouh-Amiri1, M. S. Naseer1, D. Aultman1, R. McMillan1, S. Tandukar2, F. T. Siskron3, N. Singh2, G. Zibari1

    1Advanced Surgery, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA, 2Transplant Nephrology, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA, 3Urology, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA

    *Purpose: Uretero-neocystostomy (UN) is routinely performed in renal transplantation. Few studies of primary uretero-ureterostomy (UU) have been reported, showing its safety and feasibility. If the…
  • 2021 American Transplant Congress

    Kidney Programs Can Filter Off a Majority of Their Unwanted Organ Offers without Harming Transplant Volumes

    A. Toll, H. McGehee, R. McTier, D. Stewart

    Research, United Network for Organ Sharing, Richmond, VA

    *Purpose: Evaluate if multifactorial filters can reduce unwanted kidney offers to centers, thereby reducing administrative burden and getting to the accepting candidate quicker.*Methods: 34 centers…
  • 2021 American Transplant Congress

    Long Term Survival After Liver Transplantation for Advanced, Unresectable Intrahepatic Cholangiocarcinoma

    R. R. McMillan1, S. Kodali1, M. Javle2, A. Saharia1, C. M. Mobley1, M. J. Hobeika1, A. Shetty1, D. W. Victor1, R. McFadden1, M. Abdelrahim1, K. Heyne1, A. O. Gaber1, R. M. Ghobrial1

    1Houston Methodist Hospital, Houston, TX, 2MD Anderson Cancer Center, Houston, TX

    *Purpose: Intrahepatic cholangiocarcinoma (ICCA) has traditionally been considered a contraindication to liver transplantation (LT). We previously reported a case series of six patients with large,…
  • 2021 American Transplant Congress

    Clinical Impact of Transplant Pharmacists on the Care of Solid Organ Transplant Recipients

    I. Shah1, J. Au1, A. Diamond1, N. Sifontis2, C. Ruggia-Check1

    1Temple University Hospital, Philadelphia, PA, 2Temple School of Pharmacy, Philadelphia, PA

    *Purpose: The United Network for Organ Sharing (UNOS) and Centers for Medicare and Medicaid Services (CMS) requires transplant centers to document the participation of a…
  • 2021 American Transplant Congress

    Belatacept-Resistant T Cells are Activated by IFNα-IRF7 Pathway

    F. Herr, K. Bargiel, A. Vernochet, A. Durrbach

    UMR1186, Villejuif, France

    *Purpose: Second signal of activation play an important role in activation of T lymphocytes. Their control by checkpoint inhibitor is efficient in auto-immune disease and…
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