ATC Abstracts

American Transplant Congress abstracts

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  • 2021 American Transplant Congress

    Novel Mixed Lymphocyte Reaction Monitoring System That Predicts Chronic Antibody- Mediated Rejection in Kidney Transplant Recipients

    N. Iwahara1, K. Hotta1, T. Tanabe1, D. Iwami2, Y. Takada3, H. Higuchi1, H. Sasaki3, H. Harada3, N. Shinohara1

    1Hokkaido Univercity, Sapporo, Japan, 2Jichi Medical University, Shimotsuke, Japan, 3Sapporo City General Hospital, Sapporo, Japan

    *Purpose: Chronic active antibody-mediated rejection (CAAMR) induced by de novo donor-specific antibodies (DSA) is the main cause of graft loss in the long-term. Currently, there…
  • 2021 American Transplant Congress

    Predictive Index for Liver Retransplantation

    C. Christmann, G. Handing, M. McDonald, A. Anand, S. Keeling, N. T. Galván, R. Cotton, C. O'Mahony, J. Goss, A. Rana

    Baylor College of Medicine, Houston, TX

    *Purpose: Given the increase in demand for donor livers, it has become more critical than ever to predict mortality in order to identify the best…
  • 2021 American Transplant Congress

    Hepatocyte SIRT1 Suppresses Atf4-mediated Apoptosis Triggered by Cold Stress in Mouse and Human Liver Transplantation

    K. Kadono1, H. Hirao1, H. Kojima1, K. J. Dery1, J. Aziz1, X. Li2, J. W. Kupiec-Weglinski1

    1Dumont-UCLA Transplant Center, Los Angeles, CA, 2NIEHS, Durham, NC

    *Purpose: The role of ER-stress or hepatocyte-specific SIRT1 signaling during donor liver cold preservation remains unknown. We employed a mouse OLT model and analyzed clinical…
  • 2021 American Transplant Congress

    Implications of Trends in Child to Parent Kidney Donation in Whites and African Americans

    N. Jean, S. Krishnamoorthy, Y. Kyeso, P. Cunningham, N. Murthy, R. McGill, M. Josephson

    Nephrology, University of Chicago, Chicago, IL

    *Purpose: Racial disparities in access to transplantation referral, wait listing and transplant receipt are well described. African Americans (AA) receive fewer living donor transplants than…
  • 2021 American Transplant Congress

    Mhealth Family Self-Management Intervention for Families of Transplanted Children

    S. M. Lerret1, R. White-Traut2, B. Medoff-Cooper3, S. I. Ahamed4, P. Simpson5, R. Schiffman6

    1Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, 2Children's Wisconsin, Milwaukee, WI, 3University of Pennsylvania, Philadelphia, PA, 4Department of Computer Science, Marquette University, Milwaukee, WI, 5Department of Biostatistics, Medical College of Wisconsin, Milwaukee, WI, 6University of Wisconsin Milwaukee, Milwaukee, WI

    *Purpose: Nearly 2,000 children undergo solid organ transplant in the US annually. In our previous research with transplant families, parents reported difficulty coping with the…
  • 2021 American Transplant Congress

    Single Cell RNA Sequencing of Tim1- B Cells and Tim1+ Regulatory B Cells

    Q. Fu1, K. Lee2, K. Deng2, D. Agarwal3, P. v. Galen4, C. G. Rickert2, G. Huai2, H. Yang1, C. LeGuern2, S. Deng1, J. F. Markmann2

    1Organ Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Sciences and Technology of China, Chengdu, China, 2Center for Transplantation Sciences, MGH, Boston, MA, 3Division of Transplantation, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, 4Division of Hematology, Brigham and Women's Hospital, Boston, MA

    *Purpose: Tim1 signaling has an important role in inducing and maintaining the function of Regulatory B cells. Our previous study showed that Tim1+ Bregs prolong…
  • 2021 American Transplant Congress

    Transplant Trainee Education and Recruitment Experiences

    D. E. Cassidy1, A. E. Gomez-Rexode1, J. R. Santos-Parker1, M. S. Anderson2, L. M. McElroy3, M. E. Byrnes2, S. A. Waits2, V. S. Valbuena2

    1University of Michigan Medical School, Ann Arbor, MI, 2Department of Surgery, University of Michigan Health System, Ann Arbor, MI, 3Department of Surgery, Duke University Medical Center, Durham, NC

    *Purpose: The demand for training in abdominal transplantation has continued to decrease. General surgery residents have less exposure to transplant surgery, creating a need for…
  • 2021 American Transplant Congress

    A New Triage-based Approach to Managing Transplant Referrals

    H. L. Walther

    Division of Kidney & Pancreas Transplantation, UCI Health, Orange, CA

    *Purpose: To develop and implement a novel triage-based approach to the management of referrals for kidney transplant evaluation*Methods: The transplant nurse coordinator dedicated to referral…
  • 2021 American Transplant Congress

    Invariant Nkt Cells Promote Expansion of Novel Cxcr3+Ccr4+Cd8+ T Cells in the Liver Following Allogeneic Hepatocyte Transplant

    J. Zimmerer1, B. Ringwald2, S. Chaudhari1, J. Han1, C. M. Peterson1, R. T. Warren1, M. Hart1, M. Abdel-Rasoul3, G. Bumgardner1

    1OSU, Columbus, OH, 2Medical Student Research Program, OSU, Columbus, OH, 3Center for Biostatistics, OSU, Columbus, OH

    *Purpose: Hepatocyte transplantation represents a treatment for metabolic diseases and a bridge therapy to whole organ transplant but is limited in part by cell immunogenicity.…
  • 2021 American Transplant Congress

    Iguratimod Prevents Antibody-mediated Rejection by Regulating Germinal Center Formation and Antibody Production

    H. Zhang, A. Chandraker, P. Sage, N. Murakami

    Transplantation Research Center, Brigham and Women's Hospital, Boston, MA

    *Purpose: Antibody-mediated rejection (ABMR) is a major cause of chronic renal allograft failure without effective treatment, and developing a novel therapy is an urgent need.…
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