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American Transplant Congress abstracts

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  • 2021 American Transplant Congress

    Assessing the Impact of Acute Major Adverse Kidney Events on Clinical Outcomes in Heart Transplant Recipients

    J. E. Kelly1, C. Perez1, D. Taber1, R. J. Tedford2, B. McMahon2, S. Alzaidi1, H. B. Meadows1

    1Pharmacy, MUSC Health, Charleston, SC, 2Medicine, MUSC Health, Charleston, SC

    *Purpose: The purpose of this study was to elucidate contributors to the Major Adverse Kidney Events at 30 days (MAKE-30) outcome in heart transplant recipients…
  • 2021 American Transplant Congress

    Treatment of Biopsy-Proven Pyelonephritis of the Transplanted Kidney is Associated with Better Graft Outcomes

    F. Aziz, C. Saddler, J. Alstott, K. Swanson, S. Parajuli, N. Garg, A. Djamali, D. Mandelbrot

    University of Wisconsin, Madison, WI

    *Purpose: The outcomes of treatment of pyelonephritis of the transplant kidney is not known.*Methods: From 01/1998 to 12/2019, 101 patients were found to have pyelonephritis…
  • 2021 American Transplant Congress

    Angiotensin II Type-1 Receptor Antibodies are Associated with Inferior Renal Allograft Survival

    P. Martin, E. Santos, N. Gunby, M. Willicombe

    Renal Department, Imperial College Healthcare NHS Trust, London, United Kingdom

    *Purpose: AT1R-antibodies have been implicated in antibody-mediated vascular rejection in the absence of detectable HLA donor specific antibody (DSA), in addition to cardiovascular diseases. Transplant…
  • 2021 American Transplant Congress

    Outcomes of IVIG Monotherapy for Donor-Specific Antibodies After Lung Transplantation

    K. Spence, S. Heeney, M. Morrison, S. A. Rega, F. D. Irene, K. B. Harrison, C. M. Shaver

    Vanderbilt University Medical Center, Nashville, TN

    *Purpose: De novo donor-specific antibodies (DSA) are a risk factor for antibody mediated rejection (AMR) and poor clinical outcomes after lung transplant (LT). Intravenous immune…
  • 2021 American Transplant Congress

    Developing and Validation of a Liver Transplantation Donation After Cardiac Death Risk Index Using the UNOS Database

    L. Chau, K. Delvecchio, A. Mohamed, M. Lu, T. Kitajima, S. Yedulla, K. Collins, M. Rizzari, A. Yoshida, M. Abouljoud, S. Nagai

    Division of Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI

    *Purpose: Donation after cardiac death (DCD) liver transplantation is an increasing form of organ donation. Shlegal et. al. identified seven factors predicting 1-year DCD graft…
  • 2021 American Transplant Congress

    The Effect of Covid-19 on Offer Acceptance Rates by Age and Race Groups

    A. Wey1, J. Miller1, Y. Ahn1, D. Musgrove1, A. Hart1, N. Salkowski1, M. Skeans1, R. Hirose2, A. Israni1, J. Snyder1, B. Kasiske1

    1SRTR, Minneapolis, MN, 2Univ of San Fransico, San Francisco, CA

    *Purpose: COVID-19 causes more severe complications in older patients and disproportionately leads to poor outcomes in racial minorities. High offer acceptance rates indicate better access…
  • 2021 American Transplant Congress

    Assessment of Donor-Derived Cell-Free DNA Performance Characteristics Across the Spectrum of TCMR and ABMR After Kidney Transplant

    L. Bu1, S. Anand2, A. Pai3, J. S. Bromberg4, T. Alhamad5, V. Bowers6, I. Moinuddin7, S. Ghosh8, W. Tian8, E. Stites9, G. Gupta7

    1University of Minnesota, Minneapolis, MN, 2Intermountain Medical Center, Murray, UT, 3University of Texas McGovern Medical School, Houston, TX, 4University of Maryland School of Medicine, Baltimore, MD, 5Washington University in St. Louis, St. Louis, MO, 6Tampa General Hospital, Tampa, FL, 7Virginia Commonwealth University, Richmond, VA, 8CareDx, Brisbane, CA, 9University of Colorado, Aurora, CO

    *Purpose: Different donor-derived cell-free DNA (dd-cfDNA) thresholds have been reported in association with varying TCMR, ABMR and “Borderline” diagnoses. Interpretation of dd-cfDNA levels spanning active…
  • 2021 American Transplant Congress

    Reducing Rejection in Pediatric Kidney Transplantation: The Improving Renal Outcomes Collaborative (iroc)

    C. Varnell1, A. Warmin1, G. Barletta2, C. Belsha3, L. Harshman4, D. Kershaw5, C. Pruette6, S. Ranabothu7, M. Seifert8, P. Singer9, M. Yanik10, K. Rich1, A. Modi1, D. Hooper1

    1Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Phoenix Children’s Hospital, University of Arizona, Phoenix, AZ, 3SSM Health Cardinal Glennon Children's Hospital, St Louis, MO, 4University of Iowa Stead Family Children’s Hospital, Iowa City, IA, 5C.S. Mott Children’s Hospital, Ann Arbor, MI, 6Johns Hopkins University School of Medicine, Baltimore, MD, 7Arkansas Children’s Hospital, Little Rock, AR, 8University of Alabama at Birmingham, Children’s of Alabama, Birmingham, AL, 9Cohen Children's Hospital, Brooklyn, NY, 10Levine Children's Hospital, Charlotte, NC

    *Purpose: To study the effect of implementing a Medication Adherence Promotion System (MAPS) on acute rejection (AR) rates in 9 pediatric kidney transplant (KT) programs.*Methods:…
  • 2021 American Transplant Congress

    Monoclonal Antibody Therapy for COVID-19 in Solid Organ Transplant Recipients

    Z. A. Yetmar1, E. Beam1, J. C. O'Horo1, R. Ganesh2, D. M. Bierle2, L. Brumble3, M. T. Seville4, R. R. Razonable1

    1Infectious Diseases, Mayo Clinic, Rochester, MN, 2General Internal Medicine, Mayo Clinic, Rochester, MN, 3Infectious Diseases, Mayo Clinic, Jacksonville, FL, 4Infectious Diseases, Mayo Clinic, Scottsdale, AZ

    *Purpose: Bamlanivimab and casirivimab-imdevimab are authorized for emergency use treatment of mild-to-moderate COVID-19 in patients at high-risk for progression to severe disease or hospitalization. For…
  • 2021 American Transplant Congress

    CEACAM1 Signaling is Essential to Elicit Tim-3 Inhibitory Regulation in Liver Transplantation

    H. Kojima, H. Hirao, T. Ito, K. Kadono, K. J. Dery, F. M. Kaldas, J. W. Kupiec-Weglinski

    The Dumont-UCLA Transplantation Center, Los Angeles, CA

    *Purpose: T cell immunoglobulin domain and mucin domain-3 (TIM-3) has been reported to induce T cell exhaustion. By alleviating hepatic ischemia-reperfusion injury, we have explored…
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