Session Name: Kidney Technical
Session Date & Time: None. Available on demand.
*Purpose: DGF is an important post-transplant complication that has early and long-term consequences on graft survival with increased relative risk of graft loss. DGF frequency varies widely worldwide ranging from 2-50% with the variability likely stemming from differences in rates reported by different national registries and type of donor. We sought to further evaluate effect of DGF on graft survival and glomerular filtration rate (GFR) at 1 and 3 years
*Methods: We conducted a single-center retrospective chart review of deceased donor kidney transplants recipients from March 2013 to June 2017. Baseline patient demographics, transplant characteristics were collected. The recipients were grouped into two based on IGF vs DGF. Data was analyzed on SAS version 9.3.
*Results: Of 184 recipients included in the study, 104 had IGF and 78 had DGF. The mean age was 53.5, 65.9% male, 40% Caucasian and 41.2 African American which was similar between the groups. The comorbidity burden in the cohort was high with 63.7% DM, 99% HTN and was similar amongst the groups. The mean donor age was 38.6, 25 were donation after cardiac death (DCD), mean KDPI was 53.8. At 3 year follow up, there was 9 patient death and 19 all-cause kidney allograft loss. On univariate logistic regression, DGF status did not impact 3 year patient or allograft survival. On linear regression, DGF had an negative impact on GFR at 1 year and 3 year post-transplant. with GFR being lower by 8ml/min/1/73m2 (p=0.01) (Figure 1).
*Conclusions: We found that in recipients of deceased-donor kidney transplants, non-Caucasian race was associated with and increased risk of DGF. DGF was not associated with significantly different 3 year patient or graft survival, but did associate with worse kidney allograft function, with lower 1- and 3- year GFR measurements.
To cite this abstract in AMA style:Leeds J, Rawashdeh B, Sestito M, Sharma B, Kamal J, Kumar A, AgarwalAA4VB A, Doyle A, Rao S. Evaluation of the Impact of Delayed Graft Function (dgf) on Kidney Allograft Outcomes [abstract]. Am J Transplant. 2021; 21 (suppl 3). https://atcmeetingabstracts.com/abstract/evaluation-of-the-impact-of-delayed-graft-function-dgf-on-kidney-allograft-outcomes/. Accessed June 13, 2021.
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