Session Date & Time: None. Available on demand.
*Purpose: IgA nephropathy is one of the most common glomerulonephritis after kidney transplantation. The association of IgA nephropathy recurrence with recipient HLA typing is not well understood.
*Methods: In this single-center study we included kidney transplant recipients with IgA Nephropathy native kidney disease from the period of 8/19/1994 to 3/1/2020. Diagnosis of IgA nephropathy was achieved by biopsy done in our center. All biopsies were ‘for cause’. Recipient class I and II HLA alleles for were analyzed by using logistic regression and risk for recurrence.
*Results: There were a total 238 adults with a diagnosis of IgA nephropathy in native kidneys. The mean age was 44.7 ± 13.2 years old, they were more likely to be male 169 (71%). The most common induction was T-cell depleting agent 216 (90.8%) and there were 128 (53.8%) deceased donors. In this cohort a total of 13 (5.46%) patients had biopsy proven recurrent IgA nephropathy. The recipient HLA alleles associated with increased recurrence were in HLA-CW09 (OR=9.34,p=0.01), HLA-DP105(OR=18.67,p=0.043),HLA-DP108 (OR=40.72,p=0.03); HLA-DR52*5( OR=18.7, p=0.043); HLA-DR53*3( OR=13.45,p=0.02). There was a decrease risk in HLA-B08 (OR=0.28, p=0.046), HLA-DP99 (OR=0.28, p=0.008), HLA-DRW53(OR=0.26,p=0.046). Recipient alleles HLA-A, HLA-BW, HLA-DR, HLA-DRW51 were not associated with IgA recurrence.
*Conclusions: IgA nephropathy is one of the most common recurrent glomerulonephritis and in this cohort there is an association with recipient HLA alleles. Multicenter and larger studies with long follow up will required to study IgA nephropathy recurrence.
To cite this abstract in AMA style:Alzahabi O, Merzkani M, Murad H, Java A, Santos RDelos, Alhamad T, Malone A. HLA Allele Association with Recurrent Iga Nephropathy After Kidney Transplantation [abstract]. Am J Transplant. 2021; 21 (suppl 3). https://atcmeetingabstracts.com/abstract/hla-allele-association-with-recurrent-iga-nephropathy-after-kidney-transplantation/. Accessed September 23, 2021.
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