Am J Transplant, Volume 20, Suppl 3 Archives - Page 30 of 223 - ATC Abstracts

2020 American Transplant Congress
Proposed New Kidney Allocation Policy: Moving to Concentric Circles as the First Unit of Allocation
A. Israni¹, S. Gustafson¹, A. Wey¹, B. Thompson¹, V. Casingal², M. Pavlakis³, S. Castro⁴, A. Wilk⁴, B. Kasiske¹, J. Snyder¹
¹SRTR, Minneapolis, MN, ²Carolinas Healthcare, Charlotte, NC, ³Beth Israel Deaconess, Boston, MA, ⁴UNOS, Richmond, VA
*Purpose: The Organ Procurement and Transplantation Network (OPTN) proposed a new national deceased donor kidney allocation policy that removes donor service area and OPTN region…
2020 American Transplant Congress
High-Activity Classical and Alternative Complement Pathway Genotypes – Association with Donor-Specific Antibody-Triggered Injury and Renal Allograft Survival
R. Reindl-Schwaighofer¹, B. Mezö², F. Eskandary¹, A. Heinzel¹, M. Wahrmann¹, K. Doberer¹, A. Heilos³, G. Bond¹, J. Kläger⁴, N. Kozakowski⁴, H. Haslacher⁵, R. Oberbauer¹, O. Viklický⁶, P. Hruba⁶, P. F. Halloran⁷, K. Rusai³, Z. Prohászka⁸, G. A. Böhmig¹
¹Department of Medicine III, Medical University of Vienna, Vienna, Austria, ²Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary, ³Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria, ⁴Department of Pathology, Medical University of Vienna, Vienna, Austria, ⁵Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria, ⁶Department of Nephrology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ⁷Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada, ⁸Department of Medicine III, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary
*Purpose: Complement may contribute to donor-specific antibody (DSA)-triggered transplant injury. Here, we investigated whether the intrinsic strength of classical (CP) and alternative complement pathways (AP)…
2020 American Transplant Congress
Improvement in Long Term Kidney Transplant Survival Most Dramatic among Minorities, Diabetics and Older Patients
E. D. Poggio¹, S. Arrigain², A. Wee³, D. C. Brennan⁴, J. D. Schold²
¹Nephrology, Cleveland Clinic, Cleveland, OH, ²Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, ³Urology, Cleveland Clinic, Cleveland, OH, ⁴Nephrology, Johns Hopkins, Baltimore, MD
*Purpose: Short-term and long-term kidney transplant graft survival has been improving over time, but whether this improvement in outcomes is more pronounced in the early…
2020 American Transplant Congress
Multi-Center, Open-Label Trial of Pre-Emptive Glecaprevir/Pibrentasvir (G/P) to Treat Recipients of Transplanted Kidneys from Deceased Donors with Hepatitis C Virus (MYTHIC)
M. Sise¹, D. Goldberg², J. Kort³, D. Schaubel⁴, R. Alloway⁵, C. Durand⁶, R. Fontana⁷, J. Friedewald⁸, R. Brown⁹, S. Prenner¹⁰, R. Landis⁴, P. Reese¹¹, R. Chung¹
¹Internal Medicine - Nephrology, MGH, Boston, MA, ²Hepatology and Transplantation, U Miami, Miami, FL, ³Abbvie, Chicago, IL, ⁴Department of Biostatistics, U Penn, Philadelphia, PA, ⁵Department of Internal Medicine - Nephrology and Hypertension, U Cincinnati, Cincinnati, OH, ⁶Department of Medicine, JHU, Baltimore, MD, ⁷Internal Medicine - Gastroenterology, U Michigan, Ann Arbor, MI, ⁸Internal Medicine - Nephrology and Hypertension, Northwestern, Chicago, IL, ⁹Internal Medicine - Hepatology, Weill Cornell, NYC, NY, ¹⁰Internal Medicine - Gastroenterology, U Penn, Philadelphia, PA, ¹¹Transplant Nephrology, U Penn, Philadelphia, PA
*Purpose: Kidneys from Hepatitis C virus (HCV)-infected deceased donors continue to be discarded at high rates despite small, successful studies of HCV-viremic donors into uninfected…
2020 American Transplant Congress
Outcomes of Heart Transplantation in Adults with Congenital Heart Disease Since UNOS Allocation System Change: UNOS Registry Analysis
P. Genyk, K. Yang, J. Nattiv, G. Liu, P. Banankah, P. Kingsford, J. Li, S. Nuno, K. Pandya, A. Vaidya, E. DePasquale
Department of Cardiology, Keck Medical Center of University of Southern California, Los Angeles, CA
*Purpose: We sought to examine the waiting list and post-HT outcomes in patients with congenital heart disease (CHD) within UNOS registry since the implementation of…
2020 American Transplant Congress
Notch Signaling Inhibition via Blockade of Delta-Like Ligand 4 Prevents Co-Stimulation Blockade Resistant Allograft Rejection
A. J. Matar, B. P. Lovasik, Y. Dong, D. A. Faber, J. Habib, C. A. Breeden, J. Regenold, A. Ghosh, A. Stephenson, W. H. Kitchens, A. B. Adams
Surgery and Transplantation, Emory University, Atlanta, GA
*Purpose: Co-stimulation blockade (CoB) has emerged as a promising immunosuppression strategy with the advent of Belatacept, a novel CTLA4-Ig fusion protein that blocks CD28-mediated T…
2020 American Transplant Congress
Highly Effective Short Course Therapy to Prevent Infection after Transplantation from HCV-Infected Organ Donors to Uninfected Recipients across Multiple Organ Types
A. Humar¹, M. Cypel¹, D. Kumar¹, H. Dahari², R. Vanin Pinto Ribeiro¹, N. Marks¹, N. Kamkar¹, I. Bahinskaya¹, F. Onofrio³, M. A. Zahoor³, O. Cerrochi³, K. Tinckam¹, S. J. Kim¹, T. W. Reichman¹, M. McDonald¹, T. K. Waddell¹, G. Sapisochin¹, M. Selzner¹, S. Keshavjee¹, H. L. Janssen³, B. E. Hansen³, L. Singer¹, J. Feld³
¹Transplant Centre, Toronto General Hospital, Toronto, ON, Canada, ²Loyala University, Chicago, IL, ³Toronto General Hospital, Toronto, ON, Canada
*Purpose: An increasing percentage of potential organ donors are infected with hepatitis C virus (HCV). Establishment of HCV infection in uninfected recipients is near-universal with…
2020 American Transplant Congress
Beyond the Margin: Using Kidneys from Donors on Dialysis
P. S. Patel¹, S. Karir², V. R. Peddi¹, H. Mahanty¹, S. Katznelson¹, J. Bellingham¹, N. Neidlinger¹, A. Hassoun¹, A. Sandhu¹, N. Garg¹, L. Mayen³, W. Bry¹
¹CPMC Dept of Transplantation, San Francisco, CA, ²Lewis and Clark College, Portland, OR, ³Donor Network West, San Ramon, CA
*Purpose: Outcomes for transplantation from donors with acute kidney injury have been favorable. The definition and severity of AKI have been variable. Donors who are…
2020 American Transplant Congress
Hydroxychloroquine is Associated with Better Patient and Graft Survival in Kidney Transplant Patients with Lupus Nephritis as Cause of ESRD
T. Singh¹, S. Garg², S. Panzer¹
¹Nephrology, University of Wisconsin, Madison, WI, ²Rheumatology, University of Wisconsin, Madison, WI
*Purpose: Hydroxychloroquine (HCQ) use leads to better patient and renal survival in patients with lupus nephritis (LN). Whether the clinical benefits of HCQ extends to…
2020 American Transplant Congress
Incidence of Chronic Kidney Disease after Liver Transplantation Using Measured GFR
N. R. Mazumder¹, J. Levitsky¹, G. Saracino², G. Klintmalm³, J. Trotter², S. Asrani²
¹Gastroenterology and Hepatology, Northwestern University, Chicago, IL, ²Transplant Hepatology, Baylor University Medical Center Dallas, Dallas, TX, ³Transplant Surgery, Baylor University Medical Center Dallas, Dallas, TX
*Purpose: Historical rates of ESRD after LT are 8% (1 year) and 18% (5 years) (Ojo NEJM 2003). However, these rates were based older estimates…