Am J Transplant, Volume 20, Suppl 3 Archives - Page 195 of 223 - ATC Abstracts

2020 American Transplant Congress
Biointegration and Function of 3D Printed Bionic Pancreatic Petals on a Mouse Model
M. Wszola¹, M. Klak¹, G. Tymicki¹, A. Berman¹, K. Kosowska¹, T. Bryniarski¹, P. Cywoniuk¹, M. Gomolka¹, P. Kowalska¹, P. Turowski¹, A. Kaminski²
¹Foundation for Research and Science Development, Warsaw, Poland, ²Medical University of Warsaw, Warsaw, Poland
*Purpose: Despite the technologically advanced integrated systems of continuous glycemic control and insulin supply, it is still impossible to obtain results of diabetes treatment in…
2020 American Transplant Congress
Irf8-Relevant Mechanism in B Cell Regulation In Vitro
Q. Fu¹, K. Deng², H. Yang¹, J. F. Markmann², S. Deng¹
¹Organ Transplantation Center, and School of Medicine, University of Electronic Sciences and Technology of China, Chengdu, China, ²Center for Transplantation Sciences, MGH, Boston, MA
*Purpose: Previously, we had reported that IFN regulatory factor 8 (IRF8) could be used for the identification of interstitial fibrosis and tubular atrophy (IFTA) with…
2020 American Transplant Congress
Lymphotoxin Beta Receptor Regulates Draining Lymph Node Structure and Treg Migration
V. Saxena¹, W. Piao¹, L. Li¹, Y. Xiong¹, C. C. Palusckievicz¹, T. Simon¹, M. W. Shirkey¹, R. Abdi², J. S. Bromberg¹
¹University of Maryland, Baltimore, Baltimore, MD, ²Harvard U, Boston, MA
*Purpose: To induce tolerance, regulatory T cells (Treg) are required to migrate from tissues via afferent lymphatic vessels (LV) to the draining lymph node (dLN).…
2020 American Transplant Congress
Agonistic Anti-CD272 Antibody (6B2) Suppressed Donor Specific Antibody Through Inducible Regulatory T Cells
Y. Yamamoto¹, M. Uchiyama², K. Uchida³, H. Yagita⁴, M. Niimi¹
¹Surgery, Teikyo University, Tokyo, Japan, ²Cardiovascular Surgery, Teikyo University, Tokyo, Japan, ³Hepato- Biliary- Pancreatic Surgery, Juntendo University, Tokyo, Japan, ⁴Immunology, Juntendo University, Tokyo, Japan
*Purpose: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA; CD272) is a coinhibitory molecule and may play an important role in alloimmune responses. We…
2020 American Transplant Congress
Flow Cytometric Characterization of Regulatory Cell Populations Expanded Ex Vivo from PBMCs of Kidney Transplant Recipients
S. Tripathi¹, P. L. Martin-Moreno², G. J. Kavalam¹, A. Chandraker¹
¹Renal, Brigham and Women's Hospital, Boston, MA, ²Nephrology, Clinica Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain
*Purpose: We have previously shown that it is possible to generate alloantigen-specific regulatory T cell lines and clones that prolong allograft survival upon infusion in…
2020 American Transplant Congress
Prevalence of Frailty and Cognitive Impairment at Time of Kidney Transplant Evaluation
J. Klein, A. Jurgensen, M. Gupta, N. Herrera, A. Gupta, D. Cibrik
Internal Medicine, Division of Nephrology, University of Kansas Medical Center, Kansas City, KS
*Purpose: Frailty is highly prevalent in kidney disease, with prevalence estimates as high as 73% in patients at the time of dialysis initiation compared to…
2020 American Transplant Congress
Flagging of Transplant Centers Associated with Increased Waitlist Mortality among Liver Candidates
R. L. Grant, B. A. Shelton, P. A. MacLennan, R. D. Reed, R. M. Cannon, B. J. Orandi, D. E. Eckhoff, J. E. Locke
University of Alabama at Birmingham, Birmingham, AL
*Purpose: Previous studies have demonstrated decreased transplant rates among poor performing transplant centers meeting Centers for Medicare & Medicaid Services (CMS) flagging criteria. However, no…
2020 American Transplant Congress
Additive Effect of Obesity to Hypertension in Living Donors and Their Impact on Glomerular Filtration Rate Compensation with 5 Year Follow-Up
S. Quadri¹, H. Ali², T. Fulop¹, A. Osman³, K. Soliman¹
¹Nephrology, Medical University of South Carolina, Charleston, SC, ²Renal Medicine, Royal Stoke University Hospital, Stoke-on-Trent, United Kingdom, ³Nephrology, Cairo University, Cairo, Egypt
*Purpose: Current data suggest that hypertensive donors can be considered for donation; however, the additive adverse effect of obesity and the risk of failing Glomerular…
2020 American Transplant Congress
Belatacept-Based Regimens: Induction and Recipient Gender Influence Outcomes
N. Wilson¹, A. R. Shields², A. Wiseman³, A. L. Christianson¹, S. Tremblay¹, D. Kaufman⁴, J. P. Leone⁵, A. J. Matas⁶, P. West-Thielke⁷, R. R. Alloway¹, E. S. Woodle¹
¹U Cincinnati, Cincinnati, OH, ²The Christ Hospital, Cincinnati, OH, ³U Colorado, Denver, CO, ⁴U Wisconsin, Madison, WI, ⁵Tampa General, Tampa, FL, ⁶U Minnesota, Minneapolis, MN, ⁷U Illinois Chicago, Chicago, IL
*Purpose: Renal function and adverse event profiles in kidney transplant (KTx) patients under belatacept (BELA) based immunosuppression are significantly improved over calcineurin inhibitors, however BELA…
2020 American Transplant Congress
CD56^DimCD16^Bright NK Cells from Kidney Transplant Recipients with Antibody-Mediated Rejection Display Increased Proliferation, Self-Renewal, Pro-Inflammatory and Cytotoxic Profile
E. A. Bailly¹, K. Louis¹, C. Macedo¹, B. Ramaswami¹, M. Lucas¹, A. Zeevi¹, C. Lefaucheur², D. Metes¹
¹Department of Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, ²INSERM UMR-S976. Endothelium, Inflammation & Alloreactivity, Université de Paris, France
*Purpose: Contribution of NK cells to antibody-mediated rejection (ABMR) injuries have recently been highlighted through transcriptomic analysis and immunohistochemistry of kidney and heart allograft biopsies.…