Am J Transplant, Volume 19, Suppl 3 Archives - Page 160 of 214 - ATC Abstracts

2019 American Transplant Congress
Towards Human Leukocyte Antigen Immunogenicity Assessment at the Individual Patient Level
H. Copley¹, H. McDowell², D. Pinelli², A. R. Tambur², V. Kosmoliaptsis¹
¹Department of Surgery, University of Cambridge, Cambridge, United Kingdom, ²Department of Surgery, Feinberg School of Medicine, Comprehensive Transplant Center, Northwestern University, Chicago, IL
*Purpose: Allorecognition of donor HLA and induction of humoral alloimmunity is a major cause of graft loss after solid-organ transplantation. Current approaches to study molecular…
2019 American Transplant Congress
The Use of High Volume Perioperative Normal Saline Increases the Risk of Delayed Graft Function after Kidney Transplantation
K. Kolodzie¹, O. S. Cakmakkaya², E. S. Boparai³, M. Tavakol⁴, J. Feiner¹, C. U. Niemann⁵
¹Anesthesia & Perioperative Care, University of California San Francisco, San Francisco, CA, ²Dept. of Medical Education, University Istanbul – Cerrahpasa, Istanbul, Turkey, ³School of Medicine, George Washington University, Washington, DC, ⁴Dept. of Surgery, Division of Transplantation, University of California San Francisco, San Francisco, CA, ⁵Anesthesia & Perioperative Care, and Dept. of Surgery, Division of Transplantation, University of California San Francisco, San Francisco, CA
*Purpose: Metabolic and physiologic effects of high volume perioperative Normal Saline (NS) resuscitation are well described, but the impact on delayed graft function (DGF) remains…
2019 American Transplant Congress
Differences in the Cost of Kidney Organ Recovery by Organ Procurement Organization Size
P. J. Held¹, J. Bragg-Gresham², J. P. Roberts³
¹Stanford University, Stanford, CA, ²Univ of Michigan, Michigan, MI, ³Univ of California-San Francisco, San Francisco, CA
*Purpose: Economic theory suggests that there should be an initial decrease in costs of products as production levels increase. Using data from independent OPOs we…
2019 American Transplant Congress
B7H1 Expression is Crucial for Tolerance Induction in Mouse Liver Transplantation
M. Morita¹, S. Datta¹, C. Miller², T. Hamilton¹, K. Hashimoto³
¹Inflammation & Immunity, Lerner Research Institution, Cleveland, OH, ²General surgery, Liver Transplant Center, Cleveland Clinic, Cleveland, OH, ³General Surgery, Liver Transplant Center, Cleveland Clinic, Cleveland, OH
*Purpose: Following organ transplantation, lifelong immunosuppressive treatment is required and it causes severe side effects. Induction of donor specific tolerance is ideal, which actually spontaneously…
2019 American Transplant Congress
Dichotomous Role Of Donor T Cells In The Efficacy Of Tolerogenic Therapies For Transplant Rejection
M. Iglesias Lozano, D. Bibicheff, M. Chicco, G. Brandacher, G. Raimondi
Plastic Surgery, Johns Hopkins University, Baltimore, MD
*Purpose: Costimulation blockade-based regimens are a promising strategy to promote transplant tolerance. However, their efficacy is affected by multiple factors, many of which remain unknown.…
2019 American Transplant Congress
TCR Transgenes to Understand Human Xenotolerance Induction
G. Nauman, C. Borsotti, N. Danzl, M. Khosravi-Maharlooei, H. Li, E. Chavez, Y. Yang, M. Sykes
Columbia Center for Translational Immunology, New York, NY
*Purpose: Swine thymus transplantation is a promising approach to clinical tolerance for pig-to-human xenotransplantation. In humanized mice, a swine thymus graft supports de novo selection…
2019 American Transplant Congress
Validation Of The Optimized Prediction Of Mortality (Opom) Machine Learning Model For Non-hepatocellular Carcinoma Candidates Awaiting Liver Transplant
L. Lau¹, X. Xie², F. Jia², P. D. Greig¹, T. C. Chan²
¹Multi-Organ Transplant, Department of Surgery, University of Toronto, Toronto, ON, Canada, ²Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, Canada
*Purpose: Currently the Model for End-Stage Liver Disease (MELD) is used to rank candidates for liver transplant in many jurisdictions. However, MELD does not provide…
2019 American Transplant Congress
CMV Risk Status Remains a Relevant Risk Factor for Long-Term Outcomes
G. Karadkhele, W. Zhang, C. P. Larsen
Emory University, Atlanta, GA
*Purpose: Intensification of immunosuppression using T cell depleting induction has reduced rates of acute cellular rejection after kidney transplantation. Belatacept, a first in class T…
2019 American Transplant Congress
Costimulation Blockade Modulates Humoral Responses in Highly Sensitized Transplant Recipients
J. Kwun, B. Ezekian, P. Schroder, M. Manook, J. Yoon, M. Mulvihill, K. Freischlag, J. Yi, S. Knechtle
Surgery, Duke Transplant Center, Durham, NC
*Purpose: Broad human leukocyte antigen sensitization is a significant barrier to successful solid organ transplantation. Sensitized patients have poor access to donor organs, high wait…
2019 American Transplant Congress
Frailty Associated with Increased Rates of Acute Cellular Rejection within 3 Months after Liver Transplantation
L. Fozouni, A. Lebsack, Y. Mohamad, C. Freise, P. Stock, J. Lai
UCSF, San Francisco, CA
*Purpose: Frailty, a state of decreased physiologic reserve and increased vulnerability to health stressors, has an inflammatory biologic basis and has been associated with dysregulation…