Peripheral Blood Regulatory T Cells In The Folow In The Kidney-transplant Patients
1Nephrology, Pemex, CDMX, Mexico, 2Genetics, Hospital General, CDMX, Mexico, 3UNAM, CDMX, Mexico, 4Inmunologia, UNAM, CDMX, Mexico
Meeting: 2019 American Transplant Congress
Abstract number: D146
Keywords: Co-stimulation, Rejection, T cells
Session Information
Date: Tuesday, June 4, 2019
Session Name: Poster Session D: Lymphocyte Biology: Signaling, Co-Stimulation, Regulation
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall C & D
*Purpose: Investigate the peripheral blood levels of CD4+CD25+FOXP3p3+ regulatory T cells (Tregs) in patients with kidney transplant at least one year after kidney transplantation and compare it with chronic disease undergo hemodialysis and healthy controls.
*Methods: Twelve renal-transplant patients, 12 patients with chronic kidney disease (CKD) stage G5 on dialysis, and 13 healthy control individuals were evaluated regarding the proportion of Tregs in their peripheral blood via flow cytometry.
*Results: The renal-transplant patients had a significantly lower proportion of Tregs than the hemodialysis-CKD patients and healthy controls (P<0.01). In contrast, the hemodialysis-CKD patients showed higher levels of Tregs than the renal-transplant patients and the healthy controls (P<0.01)
*Conclusions: The high level of peripheral blood Tregs in the hemodialysis-CKD patients suggests a chronic inflammatory state. However, the low frequency of Tregs in the peripheral blood from the renal-transplant patients suggests an unfavorable prognosis for allograft immune tolerance.
To cite this abstract in AMA style:
Carmona-Escamilla MA, Queipo G, Garcia-Mosqueda LA, Lascurain R. Peripheral Blood Regulatory T Cells In The Folow In The Kidney-transplant Patients [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/peripheral-blood-regulatory-t-cells-in-the-folow-in-the-kidney-transplant-patients/. Accessed March 2, 2021.« Back to 2019 American Transplant Congress