Am J Transplant, Volume 19, Suppl 3 Archives - Page 161 of 214 - ATC Abstracts

2019 American Transplant Congress
Prevention of Diabetes in the NOD Mice Reconstituted with Bone Marrow Cells from Allogeneic CD4 Knockout, CD8 Knockout or B-Cell Knockout B6 Mice
Y. Huang, H. Xu, Y. Wen, S. Ildstad
University of Louisville, Louisville, KY
*Purpose: Type 1 diabetes (T1D) is an autoimmune disorder characterized by destruction of the pancreatic beta cells by both humoral- and cell-mediated immune mechanisms. Transplantation…
2019 American Transplant Congress
Prevention of Islet Allo- and Xenograft Rejection with Immunoglobulin M Immunotherapy
M. Ma, P. Chhabra, K. Brayman
Surgery, University of Virginia, Charlottesville, VA
*Purpose: To investigate if IgM therapy mitigates islet allo- and xenotransplant rejection and promotes permanent islet survival.*Methods: 1) New onset diabetic NOD mice (n=14) were…
2019 American Transplant Congress
Population-Based Modeling of Prototypes and Determinants of Allograft Function Trajectories after Kidney Transplantation: Impact for Patient Monitoring and Risk Stratification
M. Raynaud¹, O. Aubert¹, M. Naesens², I. Juric³, N. Basic³, N. Kamar⁴, E. Huang⁵, S. Jordan⁵, B. Orandi⁶, D. Segev⁶, M. Stegall⁷, E. Morelon⁸, M. Giral⁹, E. Bailly¹⁰, E. Akalin¹¹, G. Gupta¹², M. Ladrière¹³, M. Buchler¹⁰, P. Reese¹⁴, C. Lefaucheur¹, A. Loupy¹
¹Paris, ., France, ²Leuven, ., Belgium, ³Zagreb, ., Croatia, ⁴Toulouse, ., France, ⁵Los Angeles, ., CA, ⁶Baltimore, ., MD, ⁷Rochester, ., MN, ⁸Lyon, ., France, ⁹Nantes, ., France, ¹⁰Tours, ., France, ¹¹New York, ., NY, ¹²Richmond, ., VA, ¹³Nancy, ., France, ¹⁴Philadelphia, ., PA
*Purpose: Although the current gold standard of kidney allograft patients monitoring relies on GFR assessment, little is known about long-term GFR trajectories prototypes and their…
2019 American Transplant Congress
Outcomes in Non-A1 and Non A1 B to B Deceased Donor Renal Transplantation Are Comparable to B Donor Renal Transplants
A. Brar, L. Kwon, A. Gruessner, F. Tedla, R. Gruessner, N. Sumrani, D. John, J. Renz, M. O. Salifu
SUNY Downstate Medical Center, Brooklyn, NY
*Purpose: Blood type B patients wait longer to get deceased donor (DD) renal transplants compared to other blood types. On December 2014, the US national…
2019 American Transplant Congress
Robotic-Assisted versus Open- Kidney Transplantation in Non-Obese Recipients
P. R. Modi, B. Pal, S. Singla, R. Chauhan, V. Kothari, A. Mishra, M. Modi, B. Butala, V. Kute, H. Patel, V. Trivedi
Transplantation Surgery and Urology, Institute of Kidney Diseases and Research Centre, Ahmedabad, India
*Purpose: Robotic Kidney Transplantation (RKT) is emerging modality of treatment for patient with end stage kidney diseases. It is accepted for obese recipients. However, there…
2019 American Transplant Congress
An 8-Gene Expression Assay in Peripheral Blood for Diagnosis of Antibody-Mediated Rejection after Kidney Transplantation
E. Van Loon¹, S. Gazut², S. Yazdani¹, E. Lerut¹, H. de Loor¹, M. Coemans¹, L. Noël³, L. Thorrez¹, L. Van Lommel¹, F. Schuit¹, D. Lambrechts¹, T. Van Brussel¹, B. Sprangers¹, D. Kuypers¹, M. Essig⁴, W. Gwinner⁵, D. Anglicheau⁶, P. Marquet⁷, M. Naesens¹
¹Catholic University Leuven, Leuven, Belgium, ²CEA, Gif-sur-Yvette, France, ³Necker-Enfants Malades Institute, Paris, France, ⁴CHU Limoges, Limoges, France, ⁵Hannover Medical School, Hannover, Germany, ⁶Paris Descartes, Sorbonne Paris Cité University, Paris, France, ⁷RTRS Centaure, Necker Hospital, Paris, France
*Purpose: Antibody-mediated rejection is a leading cause of graft failure after kidney transplantation. The diagnosis of antibody-mediated rejection is made by combining assessment of circulating…
2019 American Transplant Congress
Novel Activation Responses by Endothelial Cells within the Pro-Tolerogenic Intragraft Microenvironment
J. Wedel¹, K. Liu¹, P. T. Sage², C. V. Carman³, P. Bobrowicz⁴, S. Kong⁵, B. McLaughlin⁴, D. M. Briscoe¹
¹Transplant Research Program, Boston Children's Hospital, Boston, MA, ²Transplant Research Center, Brigham and Woman Hospital, Boston, MA, ³Harvard T.H. Chan School of Public Health, Boston, MA, ⁴Compass Therapeutics, Cambridge, MA, ⁵Computational Health Informatics Program, Boston Children's Hospital, Boston, MA
*Purpose: Current paradigms indicate that endothelial cells (EC) within allografts participate in the initiation and progression of allograft rejection. However, little is known about their…
2019 American Transplant Congress
Results of Litmus (nct 02541916): The Liver Immune Tolerance Bio Marker Utilization Study
A. Chruscinski¹, V. Rojas-Luengas¹, S. Moshkelgosha¹, J. Luo², H. Yowanto², Z. Galvin¹, L. Lilly¹, R. Smith¹, E. Renner¹, J. Zhang¹, D. Grant¹, O. Adeyi¹, H. Atkins³, P. Juni⁴, N. Selzner¹, S. Juvet¹, G. Levy¹
¹Multi-Organ Transplantation, University Health Network, Toronto, ON, Canada, ²Sciex, Brea, CA, ³Ottawa Hospital Research Institute, Ottawa, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada
*Purpose: Previously we reported a novel biomarker gene set for the identification of tolerance in murine models of rapamycin-induced cardiac tolerance and spontaneous hepatic tolerance.…
2019 American Transplant Congress
Antirejection Efficacy in De Novo Renal Transplant Recipients Receiving Everolimus with a Reduced-Exposure Calcineurin Inhibitor-Based Regimen: 24-Month Results from the TRANSFORM Study
H. Tedesco Silva¹, F. Citterio¹, M. Henry¹, T. R. Srinivas¹, Y. Watarai¹, S. Steinberg¹, N. Basic-Jukic¹, V. D. Garcia¹, E. Mor¹, V. R. Peddi¹, P. Narvekar², M. P. Hernandez Gutierrez², P. Bernhardt², J. Pascual¹
¹TRANSFORM Study Group, Basel, Switzerland, ²Novartis Pharma AG, Basel, Switzerland
*Purpose: To compare the antirejection efficacy outcomes of an everolimus+reduced-exposure CNI (EVR+rCNI) vs mycophenolic acid+standard-exposure CNI (MPA+sCNI) regimen in renal transplant recipients (RTxRs) from the…
2019 American Transplant Congress
Lifestyle Intervention in Renal Transplant Recipients: A Multicenter, Randomized Clinical Trial
E. Corpeleijn¹, G. Klaassen², D. M. Zelle², D. Dijkema³, I. van Vliet², F. J. Bemelman⁴, G. J. Navis², S. J. Bakker²
¹Department of Epidemiology, University Medical Center Groningen, Groningen, Netherlands, ²Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, Groningen, Netherlands, ³Department of Dietetics, University Medical Center Groningen, Groningen, Netherlands, ⁴Department of Nephrology, Amsterdam Medical Center, Amsterdam, Netherlands
*Purpose: Low physical activity and reduced physical functioning are common after renal transplantation, resulting in a reduced quality of life. The aim of this study…