Am J Transplant, Volume 19, Suppl 3 Archives - Page 134 of 214 - ATC Abstracts

2019 American Transplant Congress
RNA Splicing and Lineage Progression: Identification of an Integrated Splicing Pattern in Endodermal Lineage Progression
J. Fair¹, N. Liu¹, S. G. Widen², W. S. Fagg¹
¹Surgery, University of Texas Medical Branch, Galveston, TX, ²Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX
*Purpose: Epigenetic states such as histone modifications and DNA methylation that influence transcription are well-characterized regulators of stem cell pluripotency and differentiation to specific lineages.…
2019 American Transplant Congress
T Cell-Intrinsic Dysfunction in Donor-Specific Transplantation Tolerance
C. M. McIntosh¹, M. L. Miller², Y. Wang¹, A. Chong³, M. Alegre¹
¹Department of Medicine, University of Chicago, Chicago, IL, ²Department of Immunology, University of Pittsburgh, Pittsburgh, PA, ³Department of Surgery, University of Chicago, Chicago, IL
*Purpose: Donor-specific tolerance offers many advantages over current lifelong non-specific immunosuppression strategies, but the mechanisms by which it may be durably maintained remain to be…
2019 American Transplant Congress
Role of RIPK3 in Chronic Rejection Following Human Lung Transplantation
S. Angara, R. Ravichandran, H. Sodawalla, M. Smith, R. Bremner, T. Mohanakumar
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Immunological mechanisms leading to chronic rejection, bronchiolitis obliterans syndrome (BOS), following human lung transplantation remains unclear though a strong correlation have been identified between…
2019 American Transplant Congress
Delayed Kidney Transplantation in Combined Liver Kidney Transplantation: A Validation Analysis by the UNOS Registry
L. Chau, M. Safwan, M. Rizzari, K. Collins, A. Yoshida, M. Abouljoud, D. Moonka, S. Nagai
Transplant Surgery, Henry Ford Hospital, Detroit, MI
*Purpose: Delayed kidney transplantation for patients undergoing combined liver-kidney transplant (CLKT) have been suggested to improve patient survival and kidney function compared to simultaneous liver-kidney…
2019 American Transplant Congress
Exploring the Drivers of the Early Decline in One-Year Patient Survival after KAS
K. Lindblad, A. Wilk, D. Stewart
UNOS, Richmnd, VA
*Purpose: The OPTN implemented a new kidney allocation system (KAS) on December 4, 2014, and initial post-implementation monitoring found a statistically significant decline in one-year…
2019 American Transplant Congress
Bortezomib Based Induction Therapy Decreases Delayed Graft Function in High Risk Kidney Transplantation
K. Mahendran¹, N. Koizumi², J. K. Melancon¹
¹Transplant Institute, The George Washington University, Washington, DC, ²Schar School of Policy and Government, George Mason University, Arlington, VA
*Purpose: Over 100,000 candidates await a kidney transplant on the national United Network for Organ Sharing (UNOS) waitlist. Among these candidates, one-third have pre-formed antibodies…
2019 American Transplant Congress
Lower Incidence of Posttransplant Malignancies under Vitamin D (Calcidiol) Treatment in Kidney Transplantation
I. Revuelta¹, V. Tubita², J. Ugalde¹, D. Cucchiari¹, F. Oppenheimer¹, F. Diekmann¹, J. Campistol¹, J. Torregrosa¹
¹Department of Nephrology and Kidney Transplant, Hospital Clinic, Barcelona, Spain, ²Experimental Laboratory of Nephrology and Kidney Transplant, IDIBAPS, Barcelona, Spain
*Purpose: An increasing body of evidence has emerged on the role of 1α,25-dihydroxyvitamin D3[1,25(OH) 2 D] in cell differentiation, which seems to have regulation properties…
2019 American Transplant Congress
Hepatic Stellate Cells and Liver Derived Endothelial Cells Improve Scaffold-Free 3D-Bioprintied Liver Model
A. M. Chen¹, W. Zhang¹, C. J. Koehler¹, K. Saglam¹, A. Isidan¹, J. R. Walsh¹, R. A. Naqvi¹, E. Gramelspacher¹, L. J. Smith², P. Li¹, B. Ekser¹
¹Transplant Division, Department of Surgery, Indiana University, Indianapolis, IN, ²3D-Bioprinting Core, Indiana University School of Medicine, Indianapolis, IN
*Purpose: Hepatic stellate cells (HSC) comprise about 2-8% of liver cells and are vital to hepatocellular function. Scaffold-free 3D-bioprinting (SF3DBP) allows creation of realistic tissue…
2019 American Transplant Congress
Anti CD45RB Antibody Therapy Attenuates Renal Ischemia Reperfusion Injury by Inducing Regulatory B Cells
S. Lee¹, S. Park¹, J. Hwang¹, J. Ryu², T. Koo², C. Ahn², J. Yang³
¹Biomedical Research Institute, Transplantation Center, Seoul National University Hospital, Seoul, Korea, Republic of, ²Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ³Department of surgery, Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: Regulatory B cells (Bregs) are a new B cell subset that suppresses immune responses. Recently, both anti-CD45RB and anti-Tim-1 treatments have been found to…
2019 American Transplant Congress
Improved Transplant Outcomes in Ischemia-Free Liver Transplantation: A Report of the First 30 Cases
X. He, Z. Guo, W. Ju, Q. Zhao, S. Huang, J. Yang, L. Wang, Y. Tang, Z. Zhang, Z. Zhu, L. Yang, Y. Zhu, F. Gong, C. Cai, W. Huang, G. Chen, M. Chen, F. Ji, M. Han, A. Hu, L. Wu, Y. Ma, D. Wang, J. Huang, X. Li
Organ Transplant Center, the First Affiliated Hospital of SYSU, Guangzhou, China
*Purpose: We developed a novel procedure called ischemia-free liver transplantation (IFLT) to bridge liver grafts from donors to recipients without cessation of blood supply. Herein,…