Am J Transplant, Volume 19, Suppl 3 Archives - Page 134 of 214 - ATC Abstracts

2019 American Transplant Congress
Whole-Exome Sequencing Identifies PMS1 and DYRK1A Genes Contributing to Occurrence of Liver Cancer
Y. Zhao, B. Yang, D. Chen, L. Wei, Z. Chen
Tongji hospital, Huazhong university, Organ Transplantation, Wuhan, China
*Purpose: Liver cancer is one of the most frequent cancers in China and the accurate landscape of liver cancer, especially of HBV-infected liver cancer in…
2019 American Transplant Congress
Impact of IgG Subclass and C1q Binding Donor-Specific HLA Antibodies on Antibody Mediated Rejection in Kidney Transplant Recipients
H. Lee¹, J. Ryu¹, S. Yun¹, T. Ban², E. Ko², C. Yang², E. Oh¹
¹Department of Laboratory Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ²Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea, Republic of
*Purpose: Donor specific HLA antibody (DSA) is a leading cause of antibody mediated rejection (AMR) and graft loss in kidney transplants. It is known that…
2019 American Transplant Congress
Novel Flow-Based Assay to Identify Allo-Specific T Cell Exhaustion
N. Tanimine¹, C. Rickert¹, K. Lee¹, K. Deng¹, N. Feeney¹, C. Leguern¹, B. Burrell², J. Markmann¹
¹Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Immune Tolerance Network, Bethesda, MD
*Purpose: A recent, multi-center immunosuppression withdrawal trial in liver transplant recipients unexpectedly revealed time post-transplant as an important predictor for operational tolerance. We hypothesize that…
2019 American Transplant Congress
Significance of Histopathologic Features for Predicting Progression in Patients with Transplant Glomerulopathy
X. Li, J. Chen, D. Cheng, R. Wang, W. Wang, M. Zhang, F. Xu, J. Wen, Z. Tang
National Clinical Research Center of Kidney Diseases, Nanjing, China
*Purpose: Transplant glomerulopathy (TG) represents a major cause of long-term allograft failure and is the leading cause of overall post-transplant proteinuria. We aimed to determine…
2019 American Transplant Congress
Investigating Deceased Donor Kidney Discard Trend – An Opportunity To Expand The Donor Pool
J. A. Shah¹, D. P. Borle¹, K. Koontz², W. Irish¹, K. V. Ravindra¹
¹Abdominal Transplant Surgery, Duke University Medical Center, Durham, NC, ²Carolina Donor Services, Durham, NC
*Purpose: As the number of patients awaiting kidney transplantation increases from year to year, centers must maximize efforts to transplant kidneys procured. One way of…
2019 American Transplant Congress
DR53, You Can’t See Me: A Deceased Donor Tale of Ambiguous Typing
S. Dionne¹, S. Shetty¹, L. Santiago¹, K. Klama²
¹VRL Eurofins, Centennial, CO, ²VRL Eurofins, Philadelphia, PA
*Purpose: Our laboratory performs STAT HLA typing for an OPO using RT-PCR methodology. A 46 year old, male Caucasian deceased donor was worked up by…
2019 American Transplant Congress
Time within Therapeutic Range: A Comparison of Three Tacrolimus Formulations within Ninety Days of Renal Transplant
S. Patel, K. Khalil, A. Lichvar, E. Benedetti, P. West-Thielke
University of Illinois Hospital and Health Sciences System, Chicago, IL
*Purpose: Optimizing tacrolimus (TAC) time within therapeutic range (TTR) has been shown to improve outcomes post-transplant. To date, there are no studies assessing differences in…
2019 American Transplant Congress
Belatacept Use in High Kidney Donor Profile Index Kidney Transplant Recipients
D. Britt¹, A. Gharabagi¹, K. Botkin¹, T. Horwedel², C. Carthon¹, J. Hagopian¹
¹Pharmacy, Barnes-Jewish Hospital, St. Louis, MO, ²Veloxis Pharmaceuticals, Cary, NC
*Purpose: To determine whether the use of belatacept is associated with renal function preservation in kidney transplant recipients from donors with a kidney donor profile…
2019 American Transplant Congress
Impact of HLA-DR Matching on HLA-DQ Matching Status and the Development of Anti-HLA-DQ De Novo DSA under Calcineurin Inhibitor or Belatacept Immunosuppression
V. Jucaud¹, H. Gebel², R. Bray², M. Polinsky³, M. Everly¹
¹Terasaki Research Institute, Los Angeles, CA, ²Emory University, Atlanta, GA, ³Bristol-Myers Squibb, Princeton, NJ
*Purpose: De novo donor-specific HLA antibodies (dnDSA) that develop after kidney transplantation target more frequently allo-HLA-DQ antigens in comparison to other allo-HLA antigens. Yet, organ…
2019 American Transplant Congress
Combined Liver and Delayed Kidney Transplantation (CLKT) Enables Similar Patient Survival as Liver Transplantation Alone (LTA): Propensity Score-Based Comparison
B. Ekser¹, C. A. Kubal¹, R. S. Mangus¹, P. Mihaylov¹, J. A. Fridell¹, L. R. Timsina¹, M. Lacerda², M. Ghabril², J. A. Powelson¹, W. C. Goggins¹
¹Transplant Division - Department of Surgery - Indiana University, Indianapolis, IN, ²Gastroenterology, Indiana University, Indianapolis, IN
*Purpose: We previously showed the positive impact of delayed KT in CLKT on patient survival compared to simultaneous KT. It is well known from the…