ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Lower Incidence of Posttransplant Malignancies under Vitamin D (Calcidiol) Treatment in Kidney Transplantation

I. Revuelta1, V. Tubita2, J. Ugalde1, D. Cucchiari1, F. Oppenheimer1, F. Diekmann1, J. Campistol1, J. Torregrosa1

1Department of Nephrology and Kidney Transplant, Hospital Clinic, Barcelona, Spain, 2Experimental Laboratory of Nephrology and Kidney Transplant, IDIBAPS, Barcelona, Spain

Meeting: 2019 American Transplant Congress

Abstract number: 48

Keywords: Hypercalcemia, Malignancy, Post-transplant malignancy

Session Information

Date: Sunday, June 2, 2019

Session Name: Concurrent Session: PTLD/Malignancies: All Topics

Session Time: 2:30pm-4:00pm

 Presentation Time: 2:42pm-2:54pm

Location: Room 311

Related Abstracts
  • Impact of Cholecalciferol Repletion on Alloreactivity in Vitamin D-Deficient Hemodialysis Patients: A Randomized Controlled Trial
  • Outcomes of Solid Organ Transplant Recipients with Pre-Existing Malignancies.

*Purpose: An increasing body of evidence has emerged on the role of 1α,25-dihydroxyvitamin D3[1,25(OH) 2 D] in cell differentiation, which seems to have regulation properties of proliferative action on various cell types. Posttransplant malignancies (PTM) are higher in kidney transplant recipients (KTR), with insufficient levels of inactive Vitamin D3 (25OH-D, Calcidiol). However, our group did not find relations between levels of 25-OH Vit D and PTM as in general population does. Our aim is to study if the oral administration of Calcidiol is associated with less incidence of PTM.

*Methods: An open label, case-control, retrospective study, including 738 kidney transplanted (KT) patients in our center between 2003 and 2009 with a minimum follow-up of 5 years. Random Calcidiol oral reposition was done from 2010. Group VitD (n=129; dose:266 biweekly or monthly) and Control Group (n=609, never received vitD supplementation) were assigned retrospectively. Study was approved by the Research Ethical Committee.

*Results: 148 de novo neoplasia in 123 patients, being skin cancer the most incidence (54%). Incidence of PTM was 15.67% per year, and medium time to develop PTM was 5.6±2.1 years. No statistical differences in sex, CKD etiology, immunosuppressive treatment was observed in all patients. Serum levels of 25OH-D or calcium were not associated either. After the initiation of Calcidiol reposition period, 68 patients developed cancer, 65 in the group of no vit D reposition and only 3 patients (all cases skin cancer at 4,5, and 40 months after starting Calcidiol) in the vit D group (p<0.05). Medium time for treatment with Calcidiol was 30±16 months, and the main side effect was asymptomatic hypercalcemia.

*Conclusions: Reposition with Calcidiol seems to benefit KT by reducing the incidence of cancer development, mainly in skin cancer.

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Revuelta I, Tubita V, Ugalde J, Cucchiari D, Oppenheimer F, Diekmann F, Campistol J, Torregrosa J. Lower Incidence of Posttransplant Malignancies under Vitamin D (Calcidiol) Treatment in Kidney Transplantation [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/lower-incidence-of-posttransplant-malignancies-under-vitamin-d-calcidiol-treatment-in-kidney-transplantation/. Accessed January 22, 2021.

« Back to 2019 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Live Related Kidney Transplant Experience in Abuja, Nigeria – First Eight Cases Ever.
    • Penis Transplantation: First U.S. Experience.
    • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
    • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
    • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
    • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

    Visit Our Partner Sites

    American Transplant Congress (ATC)

    Visit the official site for the American Transplant Congress »

    American Journal of Transplantation

    The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

    American Society of Transplantation (AST)

    An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

    American Society of Transplant Surgeons (ASTS)

    The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

    Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

    Privacy Policy

    loading Cancel
    Post was not sent - check your email addresses!
    Email check failed, please try again
    Sorry, your blog cannot share posts by email.
    This site uses cookies: Find out more.