2017 American Transplant Congress
TGF-β1 Induces Transplant Kidney Interstitial Fibrosis Through Endothelial-to-Mesenchymal Transition via TGF-β/Smad and Akt/mTOR/p70S6K Pathways.
Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Background: Chronic allograft dysfunction (CAD) induced by kidney interstitial fibrosis is the main cause of allograft failure in kidney transplantation. Studies suggested that endothelial-to-mesenchymal transition…2017 American Transplant Congress
Two Promoter Polymorphisms in the Genes Encoding for Complement Regulating Proteins CD46 and CD59 in Kidney Donors Are Associated with Biopsy Proven Acute Rejection.
BackgroundComplement regulating proteins, including CD46, CD55 and CD59, protect cells against self-damage. Because of their expression on the donor endothelium, they are hypothesized to be…2017 American Transplant Congress
A Lower Mean Exposure to Tacrolimus, Not Intra-Patient Variability Is Associated with Chronic Active Antibody Mediated Rejection.
Introduction. Chronic active antibody mediated rejection (caABMR) is one of the major causes of long-term kidney graft loss. It is hypothesized that frequent underexposure and…2017 American Transplant Congress
Retrospective Analysis of Kidney Transplant Recipients with Antibody-Mediated Rejection.
Acute antibody mediated rejection (AMR) is a major cause of allograft loss.We retrospectively reviewed all kidney allograft recipients between 2002 and March 2016. Investigated the…2017 American Transplant Congress
TB Chemoprophylaxis Post Transplantation in West London.
Introduction: Active Tuberculosis (TB) is common post solid organ transplantation (SOT). Incidence post SOT in Europe is reported to be between 0.7–5%. Isoniazid (INH) is…2017 American Transplant Congress
Trends in Infection Among Kidney Transplant Recipients, 1999-2013.
Johns Hopkins School of Medicine, Baltimore, MD
Modern immunosuppression regimens have substantially reduced acute rejection and improved patient and graft survival over the last decades. However, such potent regimens may also have…2017 American Transplant Congress
Combined Perfusion of Liver and Kidney Enhances the Protective Effects of Normothermic Perfusion on Donation After Cardiac Death Porcine Livers.
The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Aims It has been showed that combined liver-kidney normothermic machine perfusion (NMP) is able to better maintain the circuit's biochemical milieu. Nevertheless, whether the combined…2017 American Transplant Congress
Early Failure of Kidney Transplants in the Current Era.
Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki, Finland
A. Purpose: The short-term outcome after kidney transplantation has improved substantially, and immunological complications rarely lead to early graft loss. However, a small proportion of…2017 American Transplant Congress
Recurrent Lupus Nephritis in a Multi-Ethnic Kidney Transplant Population.
The incidence of recurrent lupus nephritis varies among different ethnic groups. We performed a single center retrospective analysis of recurrent lupus nephritis in kidney transplant…2017 American Transplant Congress
Eculizumab Dose Reduction Is Safe by Monitoring Eculizumab Pre-Dose Level and Functional Complement Assays.
Background & aims: Untreated atypical haemolytic syndrome (aHUS) leads to ESRD and may recur after renal transplantation. Eculizumab (Ecu), a humanized antibody inhibiting terminal C5…
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