ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    Naïve and Interferon-gamma Activated Mesenchymal Stem Cells Differentially Affect Immune Responses In Vitro and In Vivo.

    R. Patil,1 K. Premanand,1 L. Halliday,1 E. Szilagyi,1 M. Willman,2 J. Yu,1 R. Hickey,1 D. Berman,2 A. Antony,1 F. Pan,1 X. Wang,1 K. McHenry,4 D. Salomon,3 N. Kenyon,2 A. Bartholomew.1

    1University of Illinois, Chicago; 2University of Miami, Miami; 3University of Illinois, Urbana-Champaign; 4The Scripps Research Institute, La Jolla

    We have observed interferon gamma-treated autologous mesenchymal stem cells (MSC) to rapidly ex vivo expand CD3+CD4+CD25- T cells to >80% CD3+CD4+C25+FoxP3+ T regulatory cells with…
  • 2017 American Transplant Congress

    Outcomes of 100 ABO Incompatible Kidney Transplants: A Single US Center Experience.

    S. Sethi, A. Vo, E. Huang, L. Varanasi, J. Choi, A. Peng, R. Najjar, S. Jordan.

    Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA

    IntroductionAcceptable patient and graft outcomes of ABO incompatible (ABOi) living donor kidney transplantation (LDKT) have been reported with the use of desensitization strategies. Data on…
  • 2017 American Transplant Congress

    Incidental Hepatocellular Carcinoma in Explanted Livers: An Assessment After LIRADS Introduction.

    S. Garcia Aroz,1 D. Ludwig,2 K. Fowler,2 N. Vachharajani,1 M. Xu,1 Y. Lin,1 M. Doyle,1 W. Chapman.1

    1Surgery, Washington University, St. Louis, MO; 2Radiology, Washington University, St. Louis, MO

    Background: Despite new technologies and improvements in imaging diagnosis, incidental and misdiagnosed hepatocellular carcinomas (HCC) are entities that remain present and problematic in liver transplantation.Methods:…
  • 2017 American Transplant Congress

    HCC and Cardiac Cirrhosis After the Fontan Procedure in a Patient with Congenital Heart Disease and Situs Inversus.

    P. Nguyen, N. Galvan, M. Kueht, C. O'Mahony, R. Cotton, A. Rana, J. Goss.

    Division of Abdominal Transplantation, Baylor College of Medicine, Houston, TX

    Introduction. Hypoplastic left heart syndrome (HLHS) is a fatal congenital cardiac anomaly for which surgical palliation is needed, the Fontan procedure. HLHS accounts for <5%…
  • 2017 American Transplant Congress

    Outcomes of Kidney Transplantation Using Deceased Diabetic Donors.

    F. Khan,1 W. Suki,1 D. Nguyen,2 E. Graviss.2

    1Department of Nephrology, Houston Methodist Hospital, Houston, TX; 2Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston, TX

    Introduction: Histological reversal of diabetic lesions in transplanted kidney once euglycemia has been restored is well documented. Conversely, it is known that diabetes status in…
  • 2017 American Transplant Congress

    Urinary Renal Progenitors Isolation: A Novel Predictor of Kidney Graft Outcome.

    A. Manonelles,1 O. Bestard,1 M. Goma,1 P. Romagnani,2 J. M. Cruzado.1

    1Hospital Univ Bellvitge, Barcelona, Spain; 2Meyer's Children Hosp, Firenze, Italy

    Background: Longterm kidney allograft outcomes remain as unmet need. Most studies focus on mechanisms of graft injury, and kidney reparative mechanisms are neglected. Isolation of…
  • 2017 American Transplant Congress

    Intravoxel Incoherent Motion MRI Is an Effective Way to Monitor Acute Allograft Rejection in Rat Models.

    S. Zeng, X. Hu.

    Urology, Chao-Yang Hospital, Beijing, China

    Objectives: To combine the intravoxel incoherent motion MRI and blood oxygen level-dependent MRI for assessment of the renal allograft pathological process undergoing acute rejection and…
  • 2017 American Transplant Congress

    New Approach for Targeted Immunotherapy in Vascularized Composite Allotransplantation.

    F. Feturi,1 H. Wang,2 Y. Brudno,2 V. Erbas,3 Z. Zhang,3 H. Sahin,3 D. Mooney,2 V. Gorantla,3 R. Venkataramanan.1

    1Department of Pharmaceutical Science, University of Pittsburgh School of Pharmacy, Pittsburgh, PA; 2A Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA; 3Department of Plastic and Reconstructive Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA

    Vascularized composite allotransplantation (VCA) have highly immunogenic skin component mandates high doses of systemic immunosuppressive drugs. Oral dosing leads to fluctuating, unpredictable blood levels that…
  • 2017 American Transplant Congress

    Steatotic Human Livers Show Inferior Function Compared to Non-Steatotic Livers During Ex-Situ Viability Assessment by Oxygenated Machine Perfusion.

    N. Karimian,1 V. Huang,1 F. Fontan,1 M. Aburawi,1 S. Geerts,1 S. Mert,1 I. Beijert,2 R. Porte,2 M. Yarmush,1 K. Uygun,1 J. Markmann,1 H. Yeh.1

    1Division of Transplantation, Massachusetts General Hospital, Boston; 2Division of Transplantation, University Medical Center Groningen, Groningen, Netherlands

    Fatty livers are frequently declined for transplantation due to high risk of primary non-function. Ex-situ oxygenated machine perfusion (MP) is superior to static cold storage…
  • 2017 American Transplant Congress

    Impact of Cytokine Gene Polymorphism on Clinical Outcome of Renal Transplantation.

    I. Pérez-Flores,1 J. Santiago,2 A. Moreno Dela Higuera,1 N. Calvo,1 B. Rodriguez-Cubillo,1 E. Urcelay,2 A. Shabaka,1 M. Calvo,1 A. Sanchez-Fructuoso.1

    1Nephrologist, Hospital Clinico San Carlos, Madrid, Spain; 2UGC Immunology, Hospital Clinico San Carlos and Instituto de Investigación Sanitaria (IdISSC), Madrid, Spain

    Cytokine production is subject to genetic regulation, in such a way that gene polymorphisms at the level of promoter or coding regions can alter their…
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