Date: Monday, May 1, 2017
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
BACKGROUND: in kidney transplantation recipients, increased biomarkers of systemic inflammation before and after the transplant are associated to worse short- and long-term renal outcomes. However, little is known about the role of systemic inflammation in the donor and if it is associated to worse graft outcomes.
MATHERIAL & METHODS: we retrospectively analyzed clinical and biochemical characteristics of all kidney brain-dead donors generated in our Hospital in the 2006-2015 period (n=194). Donors who were tested for C-Reactive Protein (CRP) in the 24 hours before BD declaration were included (n=97, 50%). Clinical and biochemical features of their respective recipients (n=165) were analyzed, comparing recipients who developed Delayed-Graft Function (DGF) (n=30) with recipients who did not (n=135).
RESULTS: in the univariate analysis, CRP was associated to DGF (p=0.025), along with dialysis vintage and RB score, while PRA, donor and recipients age/sex, ischemia time and terminal creatinine were not.
|No DGF (n=135)||DGF (n=30)||p-value|
|Age (years)||57 [46-64]||57,5 [46,75-70]||0,7|
|Dialysis vintage (months)||40 [25-63]||58 [46,5-84,75]||0,002|
|PRA > 10%||11/124 (8,1%)||4/26 (13,3%)||0,58|
|Previous transplant (yes/no)||28/107 (20.7%)||9/21 (30%)||0,39|
|Donor age (years)||54,7 +/- 13,41||58,47 +/- 15, 46||0,18|
|Donor sex (%males)||51,8%||60%||0,54|
|ECD (yes)||78/135 (57,7%)||20/30 (66.6%)||0,48|
|Donor CIT (hours)||14 [11-18]||15,5 [9,5-20,5]||0,8|
|Terminal creatinine (mg/dL)||0,9 [0,67-1,1]||1 [0,7-1,2]||0,11|
|Renal biopsy score||3 [2-4]||4 [2,25-4]||0,021|
|Donor CRP [mg/dL]||4,81 [1,42-12,2]||10,58 [5,1-18,21]||0,025|
However, in logistic regression analysis, PCR proved to be significant only in non-ECD donors (p=0.027), while it lost significance in the ECD group (p=0,76).
CONCLUSIONS: terminal donor CRP was associated to DGF in kidney transplant recipients and proved to be mostly significant in non-expanded criteria donors.
CITATION INFORMATION: Cucchiari D, Fritz D, Pedro V, Ramon A, David P, Jordi R, Frederic O, Ignacio R. Brain-Dead Donors Terminal Inflammation Is Associated to Delayed Graft Function in Kidney Transplant Recipients. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:Cucchiari D, Fritz D, Pedro V, Ramon A, David P, Jordi R, Frederic O, Ignacio R. Brain-Dead Donors Terminal Inflammation Is Associated to Delayed Graft Function in Kidney Transplant Recipients. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/brain-dead-donors-terminal-inflammation-is-associated-to-delayed-graft-function-in-kidney-transplant-recipients/. Accessed January 20, 2020.
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