2017 American Transplant Congress
Tolerant Pediatric Liver Transplant (LT) Recipients (TOL) from WISP-R (NCT00320606) Split into Two Phenotypically Distinct Groups by PD1 Expression on CD4+ T Cells at Baseline, Prior to Immunosuppression Withdrawal (ISW).
Background: Combinations of cell surface markers such as PD1, CD57, and/or KLRG1 identify T cells that may fail to respond to cognate antigen challenge –…2017 American Transplant Congress
Acute Mouse CMV Infection Abrogates Transplant Tolerance by Modulating Myeloid Cell Differentiation and Function: A Possible Role for Transcription Factor RORγt.
Cytomegalovirus (CMV) infection has long been associated with graft-dysfunction and rejection in transplant-recipients. Nevertheless, precise understanding of underlying molecular mechanisms remains unclear. Here, we investigated…2017 American Transplant Congress
BK Virus Infection and Risk of Urinary Tract Cancers Among Kidney Transplant Patients in the Transplant Cancer Match Study.
Background: Recent case series describe expression of BK virus (BKV) in tumor tissue obtained from renourinary cancers in kidney transplant recipients (KTRs). Thus, BKV may…2017 American Transplant Congress
Employment Patterns After Kidney Transplantation: Rates, Contributing Factors, and Outcomes.
Background: The costs of productivity lost in transplant patients poses a concern, as a significant number of patients are of working age. Furthermore, healthcare and…2017 American Transplant Congress
Increased Long-Term Mortality 20 years After Living Kidney Donation.
Living kidney donors are healthy at the time of donation. Consequently, a long observation period is necessary to detect possible detrimental effects of donation. Most…2017 American Transplant Congress
Increased Ischemic Inflammation Induces Recipient Endogenous Memory CD4 Cell-Graft Dendritic Cell Interactions to Provide Help for Activation of Endogenous Memory CD8 T Cells.
Immunology, Cleveland Clinic, Cleveland, OH
Memory T cells provide protection against recurrent pathogens, but memory T cells with donor-reactivity pose a major barrier to successful allograft transplant and tolerance induction.…2017 American Transplant Congress
Complement Activating Anti-HLA Antibodies: Identification of Specific Histo-Mmolecular Phenotype of Rejection for Complement-Targeting Therapy.
Addressing the heterogeneity of antibody-mediated allograft rejection by identifying phenotypes based on pathophysiology is critical for improving outcomes in transplantation. We investigated whether complement-binding anti-HLA…2017 American Transplant Congress
Donor-Specific B Cell Responses: Predicting the Future of Kidney Transplants.
Allogeneic cell and tissue transplants nearly always evoke B cell responses ascertainable by detecting donor-specific antibodies (DSA) in the circulation of the recipient. DSA are…2017 American Transplant Congress
Provision of Highly Specialized Aftercare by the Transplant Center Strongly Improves Patient and Allograft Survival in Long-Term Follow-Up After Kidney Transplantation.
Despite rapid medical advancements in the field of transplantation, mean kidney allograft survival remained at a standstill. If and to what extent a highly specialized…2017 American Transplant Congress
Gut Microbiota-Urinary Tract Infection Axis in Kidney Transplant Recipients.
Introduction. The gut microbiota has recently been identified as a risk factor for development of infectious complications like bacteremia; herein, we evaluated the relationship between…
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