ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    Improved Preservation During Normothermic Ex-Vivo Liver Perfusion with Delta Opioid Agonist (D-Ala2, D-Leu5) Enkephalin (DADLE).

    E. Beal,1 J. Kim,1 D. Hayes Jr.,2 K. Washburn,1 B. Whitson,1 S. Black.1

    1Department of Surgery, Division of Transplant, The Ohio State University Wexner Medical Center, Columbus, OH; 2Departments of Pediatrics and Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH

    Background: The metabolic demand of donor livers during prolonged normothermic ex-vivo perfusion with its associated oxygen stress is a challenge. Delta opioid agonist (D-Ala2, D-Leu5)…
  • 2017 American Transplant Congress

    Impact of Immunosuppression Adherence on De Novo Donor-Specific Antibody Formation in Renal Transplant Recipients in Canada: A Modeling Analysis.

    J. Howell,1 R. Pollock,2 J. Schwartz.3

    1Astellas Pharma Global Development, Inc., Markham, ON, Canada; 2Ossian Health Economics and Communications GmbH, Basel, Switzerland; 3Astellas Pharma Global Development, Inc., Northbrook, IL

    Acute rejection rates and short-term graft survival have improved substantially as a result of advances in immunosuppression (IS), though longer-term graft survival rates have improved…
  • 2017 American Transplant Congress

    Steroid Withdrawal Using Everolimus in Maintenance Kidney Transplant Recipients with Post-Transplant Diabetes Mellitus.

    K. Nanmoku, A. Kurosawa, T. Kubo, T. Shinzato, T. Shimizu, T. Kimura, T. Yagisawa.

    Surgical Branch, Institute of Kidney Diseases, Jichi Medical University Hospital, Shimotsuke, Tochigi, Japan

    Background: Although steroid withdrawal from conventional immunosuppressive therapy has been attempted to ameliorate various complications, especially diabetes mellitus (DM), in kidney transplant recipients, a steroid-sparing…
  • 2017 American Transplant Congress

    Tacrolimus Dose Requirement Based on the CYP3A5 Genotype in Renal Transplant Patients.

    L. Qu, Z. Xie, H. Huang, H. Jiang, J. Chen, H. Jiang, H. Jiang, J. Chen, J. Chen, J. Chen.

    Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China

    Background The aim of the present study is to determine whether CYP3A5*A and CYP3A5*G genotype is a predictive index of tacrolimus dose requirement, and also…
  • 2017 American Transplant Congress

    Pre-Transplant Panel Reactive T Cells (PRT) with IL-15 as a Risk-Stratifier of Acute Rejection in Kidney Transplant Patients on Belatacept Therapy.

    P. Cravedi,1 I. Gandolfini,1 C. Donadei,1 R. Fairchild,2 K. Newell,3 R. Mannon,4 P. Heeger,1 CTOT16 Consortium.

    1Dept of Medicine, Icahn School of Medicine at Mount Sinai, New York; 2Dept of Immunology, Cleveland Clinic, Cleveland; 3Dept of Surgery, Emory University, Atlanta; 4Renal Division, UAB, Birmingham

    While kidney transplant recipients treated with bela without calcineurin inhibitors (CNI) have better 5-10y eGFR versus those on CNI, Belatacept (bela) use is associated with…
  • 2017 American Transplant Congress

    No Impact of One Year of Everolimus, as Compared to MPA, in the Reversal of Left Ventricular Hypertrophy in Elderly Renal Transplant Recipients – Preliminary Data from Then Everold Study.

    E. David-Neto,1 F. Agena,1 M. Furtado,2 A. Rodriges,2 J. Andrade,2 F. Lemos,1 F. Paula.1

    1Renal Transplantation Service, Hospital das Clinicas – University of Sao Paulo School of Medicine, Sao Paulo, Brazil; 2Echocardiography Services, Hospital das Clinicas – University of Sao Paulo School of Medicine, Sao Paulo, Brazil

    It has been suggested that mTor inhibitors may contribute to the reversal of myocardial hypertrophy after transplantation possibly due to its biological effects like enhanced…
  • 2017 American Transplant Congress

    Superior Long-Term Hypertension Management in Pediatric Kidney Transplant Recipients with Bilateral Native Nephrectomies.

    D. Stoltz,1 A. Brubaker,1 A. Chaudhuri,2 P. Grimm,2 W. Concepcion,1 A. Gallo.1

    1Surgery, Stanford University, Palo Alto, CA; 2Pediatric Nephrology, Stanford University, Palo Alto, CA

    Introduction: Native nephrectomy in pediatric kidney transplant recipients is performed for congenital anomalies, proteinuria, intractable hypertension, malignancy, and chronic infection. Post-transplant hypertension requiring medical management…
  • 2017 American Transplant Congress

    Outcomes and Risk Factors for Graft Loss: Lessons Learned from More Than 1,056 Pediatric Kidney tx at a Single Center.

    S. Chinnakotla, P. Verghese, B. Chavers, V. Kirchner, J. Najarian.

    U of M, M

    Aim:To study outcomes and risk factors for graft loss in > 1056 pediatric renal tx.Methods:We studied outcomes by immunosuppression era: I) 1963-83 (ALG, AZA and…
  • 2017 American Transplant Congress

    Simultaneous Liver-Kidney Transplants Using Donation After Cardiac Death Donors Long Term Outcomes Not Inferior to Brain Dead Donors.

    J. Alvarez-Casas, S. Sultan, J. Scalea, K. McClure, J. LaMattina, D. Bruno, S. Hanish, R. Barth.

    University of Maryland School of Medicine, Baltimore, MD

    Background:The Simultaneous use of both Liver and Kidney from the same DCD donor has become controversial with some authors advocating that DCD organs should not…
  • 2017 American Transplant Congress

    Everolimus Is Associated with Less Weight Gain Than Tacrolimus Two Years Following Liver Transplantation: Results of a Randomized Multicenter Study.

    M. Charlton,1 M. Rinella,2 D. Patel,3 K. McCague,3 J. Heimbach,4 K. Watt.4

    1Intermountain Medical Center, Salt Lake City; 2Northwestern University, Chicago; 3Novartis Pharmaceuticals Corp., East Hanover; 4Mayo Clinic, Rochester

    Weight gain after liver transplant may lead to post-transplant complications, and is a risk factor for post-transplant metabolic syndrome (PTMS), cardiovascular events, and renal insufficiency.…
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