Am J Transplant, Volume 17, Suppl 3 Archives - Page 176 of 181 - ATC Abstracts

2017 American Transplant Congress
Suppression of T Cell Proliferation by CpG-Activated B Cells Depends on Granzyme-B and Cell-Cell Contact, but Not on IL-10.
L. Kojima,¹ S. Kimura,^1,2 K. Lee,¹ C. Schuetz,¹ L. Washburn,¹ K. Deng,¹ H. Tector,¹ B. Amundsen,^1,2 D. Ndishabandi,^1,2 A. Markmann,¹ M. Markmann-Porch,¹ T. Oura,¹ A. Alessandrini,^1,2 J. Kim,¹ H. Yeh,^1,2 J. Markmann.^1,2
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; ²Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Boston, MA
Background: Our previous studies document the potent capacity of regulatory B cells (Bregs) to mitigate allograft immunity. However, we have been largely unsuccessful in demonstrating…
2017 American Transplant Congress
Ex-Vivo Mitomycin-C Exposure Reduced Immunogenicity and Prolonged Survival of Islets by Suppressing the Secretion of Multiple Chemotaxis Factors.
N. Sato,¹ T. Anazawa,² A. Kenjyo,¹ T. Kimura,¹ R. Okada,¹ T. Ishigame,¹ Y. Kofunato,¹ J. Watanabe,¹ M. Muto,¹ A. Nishimagi,¹ M. Gotoh,¹ S. Marubashi.¹
¹Department of Surgery, Division of Hepato-Biliary-Pancreatic and Transplant, Fukushima Medical University, Fukushima, Japan; ²Department of Surgery, Graduate School of Midicine, Kyoto University, Kyoto, Japan
Background. Strategies to reduce immunogenicity of islets, and to prevent activation of pro-inflammatory events are essential to successful islet engraftment. We previously demonstrated that ex-vivo…
2017 American Transplant Congress
Pre-Transplant Non-Cytotoxic Donor Specific HLA Antibodies Do Not Increase the Risk of Graft Dysfunction in Kidney Transplant Recipients with Thymoglobulin and IVIG Induction.
A. Colovai, M. Ajaimi, N. Hayde, L. Kamal, S. Chan, C. Savchik, J. Rocca, E. Akalin.
Surgery, Montefiore Medical Center, Bronx, NY
The aim of this study was to evaluate the impact of pre-formed donor specific HLA antibodies (DSA) in a large population of kidney transplant (tx)…
2017 American Transplant Congress
Biopsies (Bx) of Renal Allografts with Antibody- + Cell-Mediated Rejection (ABMR/CMR) Exhibit Gene Expression Signatures from Both Types of Rejection.
H. Zhang,¹ C. Nast,² J. Doldron,² M. Cheung,² J. Mirocha,³ J. Kahwaji,¹ A. Vo,¹ S. Jordan,¹ M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles; ²Pathology, Cedars-Sinai Medical Center, Los Angeles; ³Biostatistics Center, Cedars-Sinai Medical Center, Los Angeles
Background: In HLA-sensitized kidney transplant patients (Pts) the concomitant presence of ABMR/CMR on Bx is associated with a more severe and (&) usually irreversible injury…
2017 American Transplant Congress
Describing the Effects of the Antibiotic Regimen Immediate Post Multi-Visceral Transplant in the Pediatric Population on the Time to First Serious Bacterial Infection.
B. Chatani,¹ J. Garcia,² C. Biaggi,² T. Beduschi,³ A. Tekin,³ R. Vianna,⁴ I. Gonzalez.⁵
¹Pediatrics, Jackson Memorial Hospital, Miami, FL; ²Pediatric Gastroenterology, University of Miami Miller School of Medicine, Miami, FL; ³Miami Transplant Institute, Miami, FL; ⁴Surgery, University of Miami Miller School of Medicine, Miami, FL; ⁵Pediatric Infectious Diseases, University of Miami Miller School of Medicine, Miami, FL
This study is designed to elucidate the effect a tailored antibiotic regimen administered immediately post multi visceral transplantation may have on the duration until first…
2017 American Transplant Congress
Estrogen Receptor Alpha Mediates Female Protection from Renal Ischemia-Reperfusion Injury Through Mechanisms Extrinsic to the Kidney.
D. Aufhauser,¹ D. Murken,¹ Z. Wang,¹ G. Ge,¹ S. Concors,¹ T. Bhatti,² W. Hancock,^2,3 M. Levine.^1,4
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; ³Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ⁴Surgery, Children's Hospital of Philadelphia, Philadelphia, PA
Introduction: Female protection from renal ischemia-reperfusion injury (IRI) is observed in both mouse and human renal transplantation. We wished to assess the role of estrogen…
2017 American Transplant Congress
Measurement of Dissolved Oxygen by ¹⁹F MRI of Microcapsules Implanted IP in Non-Human Primates.
S. Safley,¹ M. Graham,² M. Garwood,³ K. Papas,⁵ B. Weegman,^3,4 G. Barber,¹ E. Lin,¹ J. Leisen,⁷ A. Sambanis,⁶ B. Hering,² C. Weber.¹
¹Surgery, Emory University, Atlanta, GA; ²Surgery, University of Minnesota, Minneapolis, MN; ³Radiology, University of Minnesota, Minneapolis, MN; ⁴Sylvatica Biotech, Inc., Charleston, SC; ⁵Surgery, University of Arizona, Tucson, AZ; ⁶School of Chemical and Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA; ⁷School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA
Since our encapsulated NHP islet allografts and porcine islet xenografts fail after i.p. transplantation in immunosuppressed NHPs without a cellular or humoral immune response, we…
2017 American Transplant Congress
Graft Loss from Anti-GBM Nephritis: A Rare Event in Alport Syndrome, Even with a Severe COL4A5/A4/A3 Mutation.
V. Gillion,¹ K. Dahan,² E. Goffin,¹ J.-P. Cosyns,³ M. Jadoul,¹ M. De Meyer,⁴ M. Mourad,⁴ Y. Pirson,¹ N. Kanaan.¹
¹Nephrology, Cliniques Universitaires Saint-Luc, Brussels, Belgium; ²Génétique Humaine, Institut de Pathologie et de Génetique, Gosselies, Belgium; ³Pathology, Cliniques Universitaires Saint-Luc, Brussels, Belgium; ⁴Surgery and Abdominal Transplantation, Cliniques Universitaires Saint-Luc, Brussels, Belgium
Background: Alport syndrome (AS) is caused by mutations in α3/α4/α5 (IV) collagen genes, whose severity determines the progression of AS. Post-transplant outcome is good, though…
2017 American Transplant Congress
Continuation of Immunosuppression Appears to Protect Against Allosensitization in Patients Listed for a Second Kidney Transplant.
S. Kuppachi,¹ M. Sanders,¹ R. Kalil,¹ Z. Stewart,² C. Thomas.¹
¹Internal Medicine, University of Iowa, Iowa City, IA; ²Transplant Surgery, University of Iowa, Iowa City, IA
Purpose: The current standard of practice after allograft loss is to discontinue immunosuppression (IS) to decrease complications related to prolonged exposure. There is a paucity…
2017 American Transplant Congress
De Novo Malignancy Occurrence After Kidney Transplantation in HLA-Sensitized Patients Treated with B-Cell Targeting Therapy.
L. Couzi,^1,2,3 P. Davis,¹ J. Visentin,^1,2,3 B. Taton,¹ G. Guidicelli,¹ H. Kaminski,^1,2,3 P. Merville,^1,2,3 T. Bachelet.⁴
¹CHU de Bordeaux, Bordeaux, France; ²Université de Bordeaux, Bordeaux, France; ³UMR CNRS 5164 Immunoconcept, Bordeaux, France; ⁴Clinique Saint-Augustin-CTMR, Bordeaux, France
Management of high risk transplantations in patients with preformed DSA still remains a dilemma. Many groups propose to increase the immunosuppression in these patients by…