2017 American Transplant Congress
HLA Class II Molecules Partner with TLR4 to Stimulate Endothelial Cell Activation and Proliferation.
Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA
Background: Transplant recipients developing donor specific HLA antibodies (DSA) are at a higher risk for acute and chronic antibody-mediated rejection (AMR). DSA contribute to the…2017 American Transplant Congress
Phenotypic and Functional Assessment of T Cell Alloimmunity After Liver Transplantation.
In addition to its metabolic functions, the liver is also an immunologically active organ. Liver transplant recipients are often maintained on less immunosuppression when compared…2017 American Transplant Congress
IdeS, an IgG Endopeptidase, Effectively Cleaves Anti-HLA Antibody (Ab), Resulting in Inhibition of Anti-HLA Ab-Mediated NK Cell Activation and Ab-Dependent Cell-Mediated Cytotoxicity (ADCC) in HLA-Sensitized Kidney Transplant Patients (HS KTx Pts).
Background: Ab-mediated rejection (ABMR) is a major obstacle in HS KTx Pts. ADCC is a mechanism responsible for ABMR. IdeS cleaves all 4 human IgG…2017 American Transplant Congress
Donor-Derived Cell-Free DNA Normal Range and Biological Variation Defined in a Reference Population.
Purpose: Donor-derived cell-free DNA (dd-cfDNA) in the circulating blood of transplant recipients has shown promise as a non-invasive biomarker of acute rejection. This analysis was…2017 American Transplant Congress
Uromodulin and Toll-Like Receptor 4 Levels Predict Susceptibility to Bacterial Urinary Tract Infection After Renal Transplantation.
Background: Urinary tract infection (UTI) remains the most common bacterial infection after kidney transplantation (kTx) and is associated with reduced allograft function as well as…2017 American Transplant Congress
Risk Factors for Cryptococcal Disease in Transplant as Compared with Non-Transplant Patients: A Single Center Study.
Purpose: To examine clinical characteristics of non-HIV, immunocompromised patients diagnosed with cryptococcal disease, including solid-organ transplant (SOT) recipients.Methods: We performed retrospective chart review of non-HIV,…2017 American Transplant Congress
Proteasome Modulation an Effective Strategy to Ameliorate Steatotic Liver Grafts Viability After Preservation.
Recently we provided evidence for a possible protective role of proteasome inhibition during liver graft preservation. Although, several reported data confirmed that the proteolytic activity…2017 American Transplant Congress
Outcomes of Renal Disease Related to Monoclonal Gammopathy After Kidney Transplantation: A Single Center Experience.
Nephrology, Cleveland Clinic, Cleveland
Kidneys are commonly involved in patients with monoclonal gammopathies (MG). However, the role of kidney transplants (KTx) in MG still needs to be more clearly…2017 American Transplant Congress
The Adoption of Generic Immunosuppressant Medications Among Kidney and Liver Transplant Recipients Using the Colorado All Payer Claims Database.
Background: Substitution of generic for brand-name immunosuppressants has increased in solid organ transplantation following the expiration of brand patents. Our aim was to describe the…2017 American Transplant Congress
Does Choice of Induction Agent Affect Outcomes in Kidney Transplants from Deceased Donors with Acute Kidney Injury and Prolonged Cold Ischemia Time?
Nephrology, Columbia University Medical Center, New York, NY
Kidneys with acute kidney injury (AKI) have a higher rate of DGF but similar outcomes to kidneys without AKI, although most data are with kidneys…
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