Am J Transplant, Volume 17, Suppl 3 Archives - Page 176 of 181 - ATC Abstracts

2017 American Transplant Congress
Modification of Human Endothelial Cells by CRISPR/Cas9-Mediated Ablation of Class I and II Major Histocompatibility Complex Antigen Expression.
J. Merola, C. Anderson, H. Xu, T. Manes, J. Pober.
Yale School of Medicine, New Haven, CT
Human endothelial cells (ECs) derived from cord blood progenitors have significant replicative potential and are thus well suited for use in tissue engineering of vascularized…
2017 American Transplant Congress
Memory T Cells Are Decreased in Transplant Recipients Deficient in miR-182.
V. Kaul, L. Wei, X. Qu, O. Martinez, S. Krams.
Transplant Immunology Lab/Division of Abdominal Transplant, Stanford University, Stanford
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate the post-transcriptional expression of target genes. There is ample evidence that miRNAs are involved in the…
2017 American Transplant Congress
Characterization of De Novo Donor-Specific HLA Antibodies and Correlations with C4d+ Antibody-Mediated Rejection of Kidney Transplants.
R. Rajalingam,¹ D. Kopchaliiska,¹ O. Buenaventura,¹ M. Singh,² S. Tomlanovich.²
¹Immunogenetics and Transplantation Laboratory, Depart. of Surgery, University of California San Francisco, San Francisco, CA; ²Transplant Service, Department of Medicine, University of California San Francisc, San Francisco, CA
Aim: Characteristics of de novo donor-specific HLA antibodies (dnDSA) that are associated with C4d positive antibody-mediated rejection (C4d+ AMR) in kidney transplants have not been…
2017 American Transplant Congress
Epidemiology and Clinical Outcomes of Mycobacterium tuberculosis in Liver Transplant Recipients in an Intermediate Tuberculosis-Endemic Area.
S. Kim,¹ Y. Kim,¹ J. Choi,² S. Yoon,² J. Kim,³ I. Moon,³ Y. Yoo,³ D. Kim.³
¹Infectious Disease, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea; ²Hepatology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea; ³Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea
BackgroundSolid organ transplant recipients are considered a high risk group for Mycobacterium tuberculosis(TB). In Korea, the incidence of tuberculosis was estimated to be 80 per…
2017 American Transplant Congress
Does an Indeterminate Result on Pre-Transplantation Tuberculosis Interferon Gamma Release Assay Predict Risk for Post-Transplantation Infection or Rejection?
A. Zimmer,¹ R. Razonable.²
¹Infectious Diseases, University of Nebraska Medical Center, Omaha, NE; ²Transplant Center, Mayo Clinic, Rochester, MN
Purpose: Most centers use interferon gamma release assays (IGRA) to screen for latent TB in transplant candidates. Some of them have an indeterminate result due…
2017 American Transplant Congress
DNA Hypermethylation Caused by Ischemia in Kidney Transplants Predicts Future Chronic Injury to the Allograft.
L. Heylen,^1,2,3,4 B. Thienpont,^3,4 M. Naesens,^1,2 J. Depreeuw,^3,4 P. Busschaert,^3,4 D. Kuypers,^1,2 I. Jochmans,^2,5 D. Monbaliu,^2,5 J. Pirenne,^2,5 D. Lambrechts,^3,4 B. Sprangers.^1,2
¹Nephrology, University Hospitals Leuven, Leuven, Belgium; ²Microbiology and Immunology, KU Leuven, Leuven, Belgium; ³Oncology, KU Leuven, Leuven, Belgium; ⁴VIB, Leuven, Belgium; ⁵Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium
Study Purpose: DNA demethylation results from hydroxymethylation and is inhibited by hypoxia. We investigated whether ischemia during kidney transplantation induces DNA methylation changes of the…
2017 American Transplant Congress
Effect of Blood Pressure Just Before Release of the Vascular Clamps on the Renal Function of Kidney Transplantation Recipients: A Retrospective Study.
K. Tsujimura,¹ M. Ota,¹ H. Ishida,² K. Tanabe.²
¹Surgery, Tomishiro Central Hospital, Tomishiro-shi, Okinawa, Japan; ²Urology, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan
OBJECTIVE: To assess the effect of blood pressure just before release of the vascular clamps on the renal function of kidney transplantation (KTx) recipients.METHODS: We…
2017 American Transplant Congress
Acthar in Recurrent Focal Segmental Glomerular Sclerosis After Kidney Transplantation.
T. Alhamad,¹ J. Dieck,² V. Vujjini,² B. Kanawati,¹ D. Brennan,¹ N. Alachkar.²
¹Washington University in St. Louis, St. Louis; ²Johns Hopkins University, Baltimore
Treatment of Recurrent focal segmental glomerular sclerosis (FSGS) after kidney transplantation is challenging with unpredictable outcomes. Conventional therapeutic options include various combinations of plasmapheresis, steroids,…
2017 American Transplant Congress
Costimulatory Blockade in Delayed Graft Function.
J. Von Visger,¹ A. Diez,¹ U. Nori,¹ T. Pesavento,¹ R. Pelletier,² A. Rajab,² A. El Hinnawi,² H. Winters.³
¹Medicine, The Ohio State University, Columbus, OH; ²Surgery, The Ohio State University, Columbus, OH; ³Pharmacy, The Ohio State University, Columbus, OH
Background: Delayed graft function (DGF) contributes to higher risk of rejection, poorer graft survival, hospital length of stay (LOS), and other morbidities. Studies also suggest…
2017 American Transplant Congress
A Comparison of Medical Costs Among ABO-Compatible, -Incompatible, and -Minor Mismatched Living Kidney Transplantation: A Single-Center Study.
D. Fujimori, M. Okumi, K. Ungami, H. Ishida, K. Tanabe.
Urology, Tokyo Women's Medical University, Tokyo, Japan
[Background]ABO-incompatible living kidney transplantation (ABO-ILKT) is considered an effective alternative to deceased kidney transplantation. Although ABO-ILKT required extra strategies and suffered extra risks across ABO…