Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
This study is designed to elucidate the effect a tailored antibiotic regimen administered immediately post multi visceral transplantation may have on the duration until first serious bacterial infection, duration until second serious bacterial infection, development of multi-drug resistant pathogens, and all cause mortality in children.
Methods: We performed a retrospective analysis of all pediatric patients who underwent MVT from 2008-2015 in our institution. Of 31 pediatric patients, (Cohort 1) 11 children received a standardized regimen of antibiotics immediately post-operatively. (Cohort 2) 20 children received a tailored antibiotic regimen suited to their previous culture sensitivities. Their average ages were 59 and 51 months, respectively.
Results: The average times to first SBI for cohort 1 and 2 were 57 and 94 days. Every patient in cohort 1 developed a SBI by 150 days post-transplant. In fact, cohort 2 had a statistically significant prolonged time until first SBI (p<0.001). Of the children who had their first SBI, the average times to second SBI held no statistical difference (293 and 119 days). Although not statistically significant, Cohort 2 had prolonged times until the development of a MDRO (52.6 and 63.9 days). In the first 30 days both cohorts had a propensity for gram negative SBI (80%); However, after day 31, cohort 1 had a propensity for gram positive SBI (42%), while cohort 2 remained with gram negative SBI (80%).
Conclusion: A tailored antibiotic regimen for the immediate post-transplant period appears to prolong the time to the first SBI and perhaps maintain the same colonization of gram negative organisms prior to transplant. Although our data does not show differences in mortality, a longitudinal study may prove superiority in morbidity and mortality rates for a tailored antibiotic regimen.
CITATION INFORMATION: Chatani B, Garcia J, Biaggi C, Beduschi T, Tekin A, Vianna R, Gonzalez I. Describing the Effects of the Antibiotic Regimen Immediate Post Multi-Visceral Transplant in the Pediatric Population on the Time to First Serious Bacterial Infection. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:Chatani B, Garcia J, Biaggi C, Beduschi T, Tekin A, Vianna R, Gonzalez I. Describing the Effects of the Antibiotic Regimen Immediate Post Multi-Visceral Transplant in the Pediatric Population on the Time to First Serious Bacterial Infection. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/describing-the-effects-of-the-antibiotic-regimen-immediate-post-multi-visceral-transplant-in-the-pediatric-population-on-the-time-to-first-serious-bacterial-infection/. Accessed July 23, 2019.
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