Am J Transplant, Volume 17, Suppl 3 Archives - Page 175 of 181 - ATC Abstracts

2017 American Transplant Congress
Impact of Timeliness of Assessment of Positive Cytomegalovirus Polymerase Chain Reaction Results in Abdominal Organ Transplant Recipients.
K. Roach, H. Triemer, M. Hurtik, A. Mehta.
Emory University Hospital, Atlanta, GA
Purpose: The purpose of this study was to evaluate the timeliness of assessment of positive cytomegalovirus (CMV) polymerase chain reaction (PCR) results. This study served…
2017 American Transplant Congress
The Evolution of Hepatitis B Surface Antibody (Anti-HBs) Titer of the Kidney Transplant Recipients: A 5-Year Experience Guideline for the Optimal Maintaining Immunization.
W. Chancharoenthana, A. Leelahavanichkul, S. Wattanatorn, Y. Avihingsanon, K. Praditpornsilpa, N. Townamchai.
Division of Nephrology, Department of Medicine, Chulalongkorn University, Bangkok, Thailand
Background: Immunization against hepatitis B virus (HBV) in kidney transplantation (KT) recipients is recommended as KDIGO guideline. Although hepatitis B surface antibody (anti-HBs) titer of…
2017 American Transplant Congress
Evaluation of Function and TCR signaling Profile of CD57⁺ T Cells in Allo-Specific Immunity.
H. Xu,¹ T. Brennan,¹ Q. Li,² A. Kirk.¹
¹Department of Surgery, Duke University School of Medicine, Durham, NC; ²Department of Immunology, Duke University School of Medicine, Durham, NC
Our studies have showed that CD57+ cells are resistant to B7 costimulation blockade (CoB). We hypothesize that CD57+ cells are highly sensitive to T cell…
2017 American Transplant Congress
RAS Inhibition Attenuates Urine Angiotensin II-Regulated Proteins Associated with Interstitial Fibrosis and Tubular Atrophy in Kidney Transplant Recipients.
Z. Mohammed-Ali,¹ S. Reid,³ P. Yip,¹ H. Cardinal,² M.-J. Hébert,² Y. Li,⁴ S. Kim,^1,3,4 A. Konvalinka.^1,3
¹University Health Network, Toronto, ON, Canada; ²Centre de Recherche du Centre Hospitalier de l'Université de Montréal - CRCHUM, Montréal, QC, Canada; ³Institute of Medical Science, University of Toronto, Toronto, ON, Canada; ⁴Institute of Health Policy, University of Toronto, Toronto, ON, Canada
Angiotensin-II (AngII), the main effector of the renin-angiotensin system (RAS), can lead to interstitial fibrosis/ tubular atrophy (IFTA) in kidney transplant recipients, mainly through AT-1R…
2017 American Transplant Congress
Modification of Human Endothelial Cells by CRISPR/Cas9-Mediated Ablation of Class I and II Major Histocompatibility Complex Antigen Expression.
J. Merola, C. Anderson, H. Xu, T. Manes, J. Pober.
Yale School of Medicine, New Haven, CT
Human endothelial cells (ECs) derived from cord blood progenitors have significant replicative potential and are thus well suited for use in tissue engineering of vascularized…
2017 American Transplant Congress
Memory T Cells Are Decreased in Transplant Recipients Deficient in miR-182.
V. Kaul, L. Wei, X. Qu, O. Martinez, S. Krams.
Transplant Immunology Lab/Division of Abdominal Transplant, Stanford University, Stanford
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate the post-transcriptional expression of target genes. There is ample evidence that miRNAs are involved in the…
2017 American Transplant Congress
Characterization of De Novo Donor-Specific HLA Antibodies and Correlations with C4d+ Antibody-Mediated Rejection of Kidney Transplants.
R. Rajalingam,¹ D. Kopchaliiska,¹ O. Buenaventura,¹ M. Singh,² S. Tomlanovich.²
¹Immunogenetics and Transplantation Laboratory, Depart. of Surgery, University of California San Francisco, San Francisco, CA; ²Transplant Service, Department of Medicine, University of California San Francisc, San Francisco, CA
Aim: Characteristics of de novo donor-specific HLA antibodies (dnDSA) that are associated with C4d positive antibody-mediated rejection (C4d+ AMR) in kidney transplants have not been…
2017 American Transplant Congress
Epidemiology and Clinical Outcomes of Mycobacterium tuberculosis in Liver Transplant Recipients in an Intermediate Tuberculosis-Endemic Area.
S. Kim,¹ Y. Kim,¹ J. Choi,² S. Yoon,² J. Kim,³ I. Moon,³ Y. Yoo,³ D. Kim.³
¹Infectious Disease, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea; ²Hepatology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea; ³Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea
BackgroundSolid organ transplant recipients are considered a high risk group for Mycobacterium tuberculosis(TB). In Korea, the incidence of tuberculosis was estimated to be 80 per…
2017 American Transplant Congress
Does an Indeterminate Result on Pre-Transplantation Tuberculosis Interferon Gamma Release Assay Predict Risk for Post-Transplantation Infection or Rejection?
A. Zimmer,¹ R. Razonable.²
¹Infectious Diseases, University of Nebraska Medical Center, Omaha, NE; ²Transplant Center, Mayo Clinic, Rochester, MN
Purpose: Most centers use interferon gamma release assays (IGRA) to screen for latent TB in transplant candidates. Some of them have an indeterminate result due…
2017 American Transplant Congress
DNA Hypermethylation Caused by Ischemia in Kidney Transplants Predicts Future Chronic Injury to the Allograft.
L. Heylen,^1,2,3,4 B. Thienpont,^3,4 M. Naesens,^1,2 J. Depreeuw,^3,4 P. Busschaert,^3,4 D. Kuypers,^1,2 I. Jochmans,^2,5 D. Monbaliu,^2,5 J. Pirenne,^2,5 D. Lambrechts,^3,4 B. Sprangers.^1,2
¹Nephrology, University Hospitals Leuven, Leuven, Belgium; ²Microbiology and Immunology, KU Leuven, Leuven, Belgium; ³Oncology, KU Leuven, Leuven, Belgium; ⁴VIB, Leuven, Belgium; ⁵Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium
Study Purpose: DNA demethylation results from hydroxymethylation and is inhibited by hypoxia. We investigated whether ischemia during kidney transplantation induces DNA methylation changes of the…