ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    Increased T Cell Exhaustion in Dialysis Patients.

    M. Bastiaansen, A. Uffing, L. Riella.

    Transplantation Research Center, Brigham and Women's Hospital, Boston, MA

    Infection is a major complication post-transplantation. Evaluating the immune system prior to transplant may allow better optimization of immunosuppression dose. T cell exhaustion has been…
  • 2017 American Transplant Congress

    C1q+ and IgG3+ De Novo Donor Specific Antibody Are Associated with Allograft Failure in a Multicenter Cohort.

    C. Schinstock,1 M. Everly,2 M. Samaniego,3 M. Gandhi,1 R. Parikh,4 V. Sharma,4 M. Stegall,1 D. Dadhania.4

    1Mayo Clinic, Rochester, MN; 2Terasaki Research Institute, Los Angelos, CA; 3University of Michigan, Ann Arbor, Mi; 4Cornell University, New York, NY

    Introduction: De novo donor specific antibody (dnDSA) is a risk factor for antibody mediated rejection and allograft loss, but dnDSA does not always lead to…
  • 2017 American Transplant Congress

    Transcript Changes Associated with Graft Rejection Are Not Specific for Rejection Because They Are Shared with Tissue Responses to Wounding.

    P. Halloran, K. Famulski, INTERCOMEX Study Group.

    University of Alberta, Edmonton, Canada

    The diagnosis of rejection by histology is based on the presence of relatively non-specific lesions. This is because the histology lesions are actually non-specific, but…
  • 2017 American Transplant Congress

    Antibiotic Conservatorship in Orthotopic Liver Transplantation.

    J. Yee,2 D. Clark,2 R. Hogen,1,2 K. Dhanireddy,1 S. Biswas,2 J. Cobb,2 K. Matsushima,2 D. Grabo,2 A. Strumwasser.2

    1Solid Organ Transplantation, Keck Hospital of USC, Los Angeles, CA; 2Trauma, Acute Care Surgery, Surgical Critical Care, LAC+USC Medical Center, Los Angeles, CA

    Post-orthotopic liver transplantation (OLT) infections, especially multidrug resistant organisms (MDRO), are implicated in poorer outcomes, fueling efforts to elucidate risk factors for hospital acquired infections.…
  • 2017 American Transplant Congress

    Impact of STEEN vs Gelofusine as Perfusate During Normothermic Ex Vivo liver Perfusion on Outcome of Pig Liver Transplantation.

    I. Linares, D. Kollmann, J. Echeverri, M. Kaths, R. Rosales, C. Bruguera, M. Hamar, P. Urbanellis, S. Ganesh, N. Selzner, M. Selzner.

    Multiorgan Transplant Program, Toronto General Hospital, Toronto, ON, Canada

    European and North American clinical trials have used two different perfusate solutions for normothermic ex vivo liver perfusion (NEVLP): Gelofusine (bovine derived gelatin-based solution) and…
  • 2017 American Transplant Congress

    EPOR2/ßcR2-Independendent Effects of Low-Dose Epoetin-a in Porcine Liver Transplantation.

    L. Kebschull,1 F. Becker,1 L. Theilmann,1 B. Heitzplatz,2 W. Uennigmann,1 H. Spiegel,1 D. Palmes.1

    1Department for General and Visceral Surgery, University Hospital Münster, Münster, Germany; 2Pathology, University Hospital Münster, Münster, Germany

    Introduction: Ischemia-reperfusion injury (IRI) remains the key component of graft damage during transplantation. Mechanistically, cold-induced apoptosis, microcirculatory disturbances and radical oxygen species formation contribute to…
  • 2017 American Transplant Congress

    Healthcare Resource Utilization for Patients with Donor-Specific Antibodies Post-Kidney Transplantation.

    B. Ho,1 H. Bhagat,2 E. Lee,2,3 K. Atiemo,1 A. Daud,1 R. Kang,1 S. Montag,1,4 L. Zhao,1,4 J. Schwartz,2 D. Ladner.1

    1Northwestern University Transplant and Outcomes Research Collaborative (NUTORC), Chicago; 2Astellas Pharma Global Development, Northbrook; 3Now with UCB, Atlanta; 4Dept of Preventive Medicine, Northwestern University, Chicago

    Formation of de novo donor-specific antibodies (dnDSA) against human leukocyte antigens (HLA) contributes to inferior kidney transplant (KT) outcomes. No data exist on healthcare resource…
  • 2017 American Transplant Congress

    Evaluating Patients' Experiences Towards Their Immunosuppressive Treatment: A Way to Improve Adherence.

    C. Villeneuve,1,2 M. Grau,1 M. Essig,2,3 S. Hegarat,3 J. Zoughbi,3 P. Marquet,1,2 C. Monchaud.1,2

    1Service of Pharmacology, Toxicology and Pharmacovigilance, CHU Limoges, Limoges, France; 2INSERM UMR850, INSERM, Limoges, France; 3Service of Nephrology, Dialysis and Transplantation, CHU Limoges, Limoges, France

    In transplantation, low therapeutic adherence is associated with an increased risk of rejection, chronic allograft dysfunction and graft loss. Improving adherence necessitates identifying its barriers,…
  • 2017 American Transplant Congress

    Role of Induction Therapy in Low Immune Risk Kidney Transplant Recipients: A Mate Kidney Analysis.

    M. Sampaio, K. Sureshkumar.

    Nephrology, Internal Medicine, Allegheny General Hospital, Pittsburgh, PA

    In the current era of powerful maintenance immunosuppression, it is unclear whether induction therapy positively adds to the outcomes in low immune risk kidney transplant…
  • 2017 American Transplant Congress

    Biliary Complications Following Liver Transplantation – Single-Center Experience Over Three Decades and Recent Risk Factors.

    A. Kaltenborn, A. Gutcke, H. Schrem, J. Gwiasda.

    Core Facility Quality Management Transplantation, Hannover Medical School, Hannover, Germany

    This study aims to identify independent risk factors for biliary complications after liver transplantation over 3 decades in a large single center. 1607 consecutive liver…
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