2017 American Transplant Congress
Intraabdominal Infections (IAI) and Bloodstream Infections in Small Intestinal and Multivisceral Transplants (IMVTX).
BackgroundIMVTX is a treatment option for patients with intestinal failure. IMVTX is often complicated by infection in the post-transplant period with the abdomen and bloodstream…2017 American Transplant Congress
Early Results of Immune Profile Emerging Before Detection of De Novo Humoral Alloimmunity in Kidney Transplant Recipients.
The purpose of this IRB-approved study is to determine if there is a potential role for CD8+ T cell-mediated suppression of donor specific alloantibody (DSA)…2017 American Transplant Congress
Transplant Center Variability in Disparities for African-American Kidney Transplant Recipients.
Disparities research has traditionally focused on patient-level variables to ascertain predominant risk factors driving differences in outcomes for African-American (AA) kidney transplant (KTX) recipients. The…2017 American Transplant Congress
A Combination of Anti-CD40L-Ab, Rapamycin, and Donor Apoptotic Cells Prolongs Allogeneic Pancreatic Islet Survival in Sensitized Mice by Regulating Memory Responses.
Accelerated rejection of allografts has been a clinical challenge in solid organ transplantation particularly in sensitized recipients with donor-specific antibodies (DSA) and memory cell repertoires.…2017 American Transplant Congress
Impact of a B-Cell Targeting Agent on Antibody Mediated Rejection and Graft' Survival in Liver Transplantation with Preformed DSAs.
Introduction The negative impact of preformed anti-HLA donor specific antibodies (DSAs) in liver transplantation is clearly established. However, the potential interest of a B-cell depleting…2017 American Transplant Congress
Myeloid HO-1 Orchestrates Liver Graft Function via SIRT1/p53 Signaling: From Mouse-to-Human.
Background/Aim: Although the efficacy of heme oxygenase-1 (HO-1) to combat liver ischemia-reperfusion injury (IRI) in animal models is well-established, cell-specific HO-1 function and mechanisms of…2017 American Transplant Congress
Efficacy and Safety of Everolimus with Reduced-Exposure Tacrolimus and Corticosteroid Withdrawal in De Novo Pediatric Renal Transplant Recipients: 12-Month Results from the CRADLE Study.
PURPOSE: We present 12-month (M) results from the CRADLE study (NCT01544491) that assessed efficacy and safety of everolimus (EVR) with reduced-exposure tacrolimus (rTAC) and early…2017 American Transplant Congress
Elevated Circulating AT1R Levels Indicate Heightened Risk for Antibody Mediated Rejection and Graft Failure.
Transplant Surgery, VCUHealth Systems, Richmond, VA
Background.Antibody(Ab) against the angiotensin II receptor(AT1R) can cause antibody mediated rejection(AMR) and graft failure after transplantation. We evaluated whether circulating AT1R is a potential marker…2017 American Transplant Congress
Microarray Analysis of Rejection in Formalin-Fixed Paraffin-Embedded Biopsies: Similarities and Disparities with Conventionally Stabilized Biopsies.
Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada
Despite potential for performing molecular diagnostics on formalin-fixed paraffin embedded (FFPE) biopsies, there has been no systematic comparison of microarray gene expression data obtained from…2017 American Transplant Congress
iNKT Cell Activation Plus Veto Cell Transfer Yields Complete Chimerism in a Murine Sub-Lethal Bone Marrow Transplant Model.
Transplant tolerance induction makes it possible to preserve functional grafts for a lifetime without immunosuppressants. We have previously established a novel method for mixed chimera…
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