2017 American Transplant Congress
Early Acute Cellular Rejection(eACR) as a Marker of Immunologic Competency Following Liver Transplantation(LT).
University of Minnesota, Minneapolis, MN
Background:Historically eACR did not adversely impact patient survival(PS). Since infection(Ifx) is major cause of death(COD) among LT recipients, we hypothesized that eACR is marker of…2017 American Transplant Congress
CD4 T Cell Migration Across Lymphatic Endothelium Is Enhanced by Sphingosine 1-Phosphate (S1P) and Differentially Regulated by S1P Receptors (S1PR).
1UMB, Baltimore; 2UM, Minneapolis
Introduction: S1PR1 drives T cells to migrate from thymus to blood, and from lymph node (LN) to efferent lymphatics. Whether S1PR1 or other S!PRs regulate…2017 American Transplant Congress
Increasing Organ Supply in the US: A Systematic Review of Presumed Consent vs. Informed Consent (2006-2016).
Purpose: Literature was systematically reviewed from 2006 to 2016 to assess the effectiveness of presumed consent vs. informed consent on increasing the deceased donor organ…2017 American Transplant Congress
Endocapillary NK Cells Are Increased in Indication Renal Transplant Biopsies with Antibody and T Cell Mediated Rejection.
Pathology, University of Michigan Medical School, Ann Arbor, MI
Detection of NK cell transcripts in renal transplant biopsies is associated with antibody mediated rejection (AMR). Similarly, quantification of endocapillary NK cells in paraffin tissue…2017 American Transplant Congress
One-Year Graft and Patient Survival of Deceased Donor Kidney Transplants Under KAS.
Background: The new kidney allocation system (KAS) was implemented on 12/4/14 and led to more transplants for highly sensitized and long-term dialysis patients. Clinical characteristics…2017 American Transplant Congress
Comparing the Role of Post-Transplant Readmissions and Bed Days on Total One Year Cost of Care.
This study examines the marginal impact of readmissions and total bed days during the 90-day period following transplant in order to better understand drivers of…2017 American Transplant Congress
VO2peak: A Significant Marker of All-Cause Mortality Among Patients with End-Stage Renal Disease Being Evaluated for Kidney Transplant.
1Mayo Clinic AZ, Phoenix; 2ASU, Tempe
Background: Peak oxygen uptake (VO2peak), obtained from cardiopulmonary exercise testing is a marker of functional capacity and a modifiable risk factor. VO2peak is a strong…2017 American Transplant Congress
Belatacept After Kidney Transplantation in Adolescents.
Pediatric Nephrology, Hannover Medical School, Hannover, Germany
Background: Regardless of recipient age at kidney transplantation (KTx), patients are at greatest risk for graft loss in adolescence. This is in part due to…2017 American Transplant Congress
A Regulatory T Cell (Treg)-Intrinsic Role for p27kip1 in Acquired Transplant Tolerance.
Pathology, The Children's Hospital of Philadelphia, Philadelphia, PA
We previously found that the cyclin-dependent kinase CDK2 phosphorylates the Treg transcription factor Foxp3, targeting it for proteolytic degradation. Treg with defective CDK2 activity express…2017 American Transplant Congress
A Molecular Approach to Chronic Rejection: Antibody or T-Cell Mediated?
Montefiore Medical Center Transplant Center, Albert Einstein College of Medicine, NY
Despite the advances in diagnosis of chronic antibody-mediated rejection (CAMR), chronic T cell mediated rejection (CTCMR) is solely defined by Banff classification as chronic allograft…
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