Am J Transplant, Volume 16, Suppl 3 Archives - Page 70 of 180 - ATC Abstracts

2016 American Transplant Congress
Enhanced Activation of Hemostasis During Kidney Transplantation in Patients on Dialysis Compared to Pre-Emptively Transplanted Patients.
T. van den berg, G. Nieuwenhuijs-Moeke, S. Bakker, R. Pol, T. Lisman.
Groningen Transplant Center, University Medical Center Groningen, Groningen, Netherlands.
Introduction: It is generally assumed that dialysis patients (DP) have a more severe bleeding diathesis related to platelet dysfunction than pre-emptively transplanted patients (PEP) who…
2016 American Transplant Congress
Antithymocyte Globulin (ATG) versus Anti-interleukin-2 Receptor (Anti-IL-2R) as Induction Therapy for Kidney Transplantation After a Nonrenal Transplant.
H. Mai,¹ K. Trébern-Launay,¹ C. Legendre,² M. Kessler,³ L. Rostaing,⁴ V. Garrigue,⁵ E. Morelon,⁶ S. Brouard,¹ M. Giral,¹ J.-P. Soulillou.¹
¹Service de Néphrologie et Transplantation, INSERM UMR 1064, CHU de Nantes, Nantes, France; ²Hôpital Necker, Paris, France; ³CHU de Nancy, Nancy, France; ⁴CHU de Toulouse, Toulouse, France; ⁵CHU de Montpellier, Montpellier, France; ⁶CHU de Lyon, Lyon, France.
Patients undergoing kidney transplant after a previous nonrenal organ transplant (NRT) present a small but emerging subpopulation of kidney transplant recipients. Little is known about…
2016 American Transplant Congress
C5a Induces CSF1-Dependent Regulatory Macrophage (Mreg) Development Required for Murine Allograft Tolerance.
I. Llaudo, P. Conde, J. Ochando, P. Heeger.
Icahn School of Medicine at Mount Sinai, New York, NY.
Anti-CD40L (MR1) induced heart transplant tolerance has been recently shown to be dependent on early post-transplant intragraft accumulation of CD11b+Ly6CLoLy6G- DC-SIGN expressing Mreg that develop…
2016 American Transplant Congress
Delayed Induction of Mixed Chimerism Permits Kidney-Induced Cardiac Allograft Tolerance to be Applied to Recipients of Cadaveric Organs.
M. Tonsho,¹ G. Benichou,¹ R. Yu,¹ S. Boskovic,¹ R. Colvin,^1,2 E. Farkash,² R.-N. Smith,² J. Allan,^1,4 A. Cosimi,¹ T. Kawai,^1,3 J. Madsen.^1,4
¹Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA; ²Department of Pathology, Massachusetts General Hospital, Boston, MA; ³Department of Surgery, Massachusetts General Hospital, Boston, MA; ⁴Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA.
(BACKGROUND)Cardiac tolerance in nonhuman primates (NHPs) has been induced for the first time by kidney co-transplantation in combination with donor bone marrow infusion when the…
2016 American Transplant Congress
Avoidance of CNI and Steroids Using Belatacept – A Preliminary Report of CTOT-16.
R. Mannon,¹ P. Stock,² A. Mehta,³ D. Ikle,⁴ N. Watson,⁵ N. Bridges,⁵ M. Robien,⁵ K. Newell.³
¹UAB, Birmingham; ²UCSF, San Francisco; ³Emory, Atlanta; ⁴Rho, Chapel Hill; ⁵NIAID, Bethesda.
CTOT-16 tested the hypothesis that belatacept used as maintenance immunosuppression (IS) in kidney transplantation would allow the long-term avoidance of CNI and corticosteroids. Methods: Primary…
2016 American Transplant Congress
Where Are the KDPI 0-20% Kidneys Going in the New KAS? A Major Allocation Shift.
M. Aeder,¹ N. Turgeon,² A. Kucheryavaya,³ D. Stewart.³
¹Univ Hosp Case Med Ctr, Cleveland, OH; ²Emory Univ, Atlanta, GA; ³UNOS, Richmond, VA.
The introduction of KAS in December 2014 marked an effort to incorporate a longevity metrics into deceased organ allocation by prioritizing retrieved kidneys with the…
2016 American Transplant Congress
Blockade of HLA Antibody-Triggered Classical Complement Activation by High-Affinity Humanized Monoclonal Anti-C1s Antibody TNT009 – Results of a First-in-Human Phase 1 Trial.
J. Mühbacher,¹ B. Jilma,² M. Wahrmann,³ L. Marinova,³ F. Eskandary,³ J. Gilbert,⁴ S. Panicker,⁴ G. Böhmig.³
¹Department of Surgery, Medical University of Vienna, Vienna, Austria; ²Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria; ³Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria; ⁴True North Therapeutics, Inc., South San Francisco, CA.
Study purpose: Classical complement may play a key role in ABMR. A promising therapeutic approach could be complement inhibition at the level of key component…
2016 American Transplant Congress
Complexity of Hylinosis in Renal Transplant Biopsies: Donor Age, Glomerular Disease, and Time.
G. Einecke,¹ J. Reeve,² P. Halloran.^2,3
¹Nephrology, Hannover Medical School, Hannover, Germany; ²Alberta Transplant Applied Genomics Centre, Edmonton, Canada; ³Department of Medicine, Division of Nephrology and Transplant Immunology, University of Alberta, Edmonton, Canada.
Arteriolar hyalinosis lesions (ah) are often interpreted as a sign of calcineurin inhibitor toxicity even though they are induced by other conditions. We studied the…
2016 American Transplant Congress
Large Single-Center Experience of Sofosbuvir and Ledipasvir Therapy for the Treatment of Post-Liver Transplant Patients with Hepatitis C Virus.
J. Wedd, R. Ford, J. Norvell, S. Parekh, N. Cheng, N. Young, A. Patel, R. Maheshwari, R. Vora, O. Mgbemena, J. Spivey, A. Pillai.
Medicine, Emory University, Atlanta, GA.
Background/Aims: Controlled trials of direct acting antiviral therapy for Hepatitis C Virus (HCV) show impressive sustained virologic response (SVR) rates, but post-transplant data of sofosbuvir…
2016 American Transplant Congress
Non-Invasive – Minimalistic Approach Using Cell-Free MicroRNAs in Paired Plasma and Urine Samples for Early Diagnosis of Chronic Renal Allograft Dysfunction.
S. Bontha,¹ R. Gehrau,¹ E. Rhone,¹ A. King,² L. Gallon,³ K. Brayman,¹ D. Maluf,¹ V. Mas.¹
¹Surgery, UVA, Charlottesville, VA; ²VCU, Richmond; ³NWU, Chicago.
Background: Reducing use of tissue biopsy by efficiently using non-invasive samples for continuous monitoring and evaluation of graft function would be ideal. Reports indicate continuous…