ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Dysfunctional Production of Adipocytokines in Obesity Results in Inferior Oncologic Outcomes from Hepatocellular Carcinoma Following Liver Transplantation.

A. Mathur, E. Presbyskowski, D. Carpenter, E. Zorn, J. Guarrera, B. Samstein, A. Griesemer, K. Halazun, Y. Veras, K. Tomoaki, J. Emond.

Abdominal Transplant, Columbia University, Ny, NY.

Meeting: 2016 American Transplant Congress

Abstract number: A195

Keywords: Hepatocellular carcinoma, Obesity

Session Information

Date: Saturday, June 11, 2016

Session Name: Poster Session A: Liver - Hepatocellular Carcinoma and Cholangiocarcinoma Malignancies

Session Time: 5:30pm-7:30pm

 Presentation Time: 5:30pm-7:30pm

Location: Halls C&D

Related Abstracts
  • Predictors of Time to Recurrence and Mortality Associated With Recurrent Hepatocellular Carcinoma After Liver Transplantation
  • The Role of Obesity in Survival Outcomes of Liver Transplant Recipients with High MELD Score.

Introduction

Over 2 billion people worldwide are obese. There is strong evidence of an association between obesity and hepatocellular (HCC) cancer.This effect is mediated through an abnormal production of adipose-derived adipocytokines (leptin and adiponectin). In-situ leptin has been shown to accelerate HCC growth and dissemination and adiponectin has been shown to oppose its effects.

Orthotopic liver transplant (OLT) represents a potentially curative procedure for HCC patients. However, no data are currently available on the mechanistic role of leptin, adiponectin and other adipocytokines on oncologic outcomes of HCC patients undergoing OLT.

Hypothesis

We hypothesize that obese patients with HCC undergoing OLT have higher levels of leptin and lower adiponectin and this correlates with increased tumor grade, and recurrence than non-obese patients.

Methods

Between January 2011-May 2015 60 HCC+OLT patients were prospectively enrolled into a cohort study of patients with a BMI<25 and BMI≥25. We collected serum prior to transplant. Serum samples were analyzed for leptin, adiponectin, IL-6, TNF-alpha, IL-8, IP-10, VEGF, and HGF. These biomarkers were correlated with outcome variables including HCC recurrence and explant pathology. Statistics were analyzed using Sigmastat software.

Results

Median age of all patients was 59years and 75% were male. Etiology was 81.7% HCV; 11.7% HBV; 3.3% NAFLD; 3.3% Cryptogenic. Mean lab MELD was 16. No differences were noted in etiology or MELD across spectrum of BMI.

BMI %Pts Within Milan Leptin (pg/ml) Adiponectin (pg/ml) IL-6 (pg/ml) Tumor Grade ≥3 % Recurrence
BMI<25 100% 9,343 +/- 7525 803,3992 +/- 167793 11+/- 6 18% 0%
BMI≥25 100% 30,963* +/- 2999 236,3437* +/- 150641 16 +/- 14

37%*

8%
*p<0.05 vs BMI <25            

Conclusions

These data show that in patients within Milan criteria obesity is associated with poorer tumor grade on explant pathology and an increased recurrence. Furthermore, this effect is mechanistically caused by elevated pro-tumorogenic leptin and attenuated adiponectin production in obesity. Therefore, we propose that adipocytokines are a meaningful prognostic biomarker in patients with HCC and further studies need to be done to evaluate their potential role in the appropriate allocation of precious donor livers.

CITATION INFORMATION: Mathur A, Presbyskowski E, Carpenter D, Zorn E, Guarrera J, Samstein B, Griesemer A, Halazun K, Veras Y, Tomoaki K, Emond J. Dysfunctional Production of Adipocytokines in Obesity Results in Inferior Oncologic Outcomes from Hepatocellular Carcinoma Following Liver Transplantation. Am J Transplant. 2016;16 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Mathur A, Presbyskowski E, Carpenter D, Zorn E, Guarrera J, Samstein B, Griesemer A, Halazun K, Veras Y, Tomoaki K, Emond J. Dysfunctional Production of Adipocytokines in Obesity Results in Inferior Oncologic Outcomes from Hepatocellular Carcinoma Following Liver Transplantation. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/dysfunctional-production-of-adipocytokines-in-obesity-results-in-inferior-oncologic-outcomes-from-hepatocellular-carcinoma-following-liver-transplantation/. Accessed March 8, 2021.

« Back to 2016 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Home
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Search
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Home
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.