ATC Abstracts

American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    Role of Natural Killer Cells in Kidney Transplant Outcome.

    E. Carta,1 R. Littera,2 M. Murgia,1 M. Michittu,1 B. Onano,1 G. Piredda,1 D. Argiolas.1

    1Renal Transplant Unit, Azienda Brotzu, Cagliari, Italy; 2Regional Transplant Coordination, ASL 8, Cagliari, Italy.

    Aim of the study was to evaluate the relationship between killer cell immunoglobulin-like receptor (KIR) phenotype and kidney transplant rejection. NK-target cell interaction depends on…
  • 2016 American Transplant Congress

    Comparison of Once-Daily and Twice-Daily Low-Dose Tacrolimus in Living Related Kidney Transplantation – Prospective Trial of Once-Daily vs. Twice-Daily Tac – 5 Years Second Report.

    T. Tsuchiya, H. Ishida, T. Nozaki, H. Shirakawa, T. Shimizu, K. Omoto, M. Okumi, K. Tanabe.

    Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.

    Background; Previously, we reported a comparison of the safety and pharmacokinetics between a prolonged-release formulation of Tacrolimus (Tac-QD) and twice-daily tacrolimus (Tac-BD) in the early…
  • 2016 American Transplant Congress

    Th17 Development Is Critical for Airway Epithelial Injury After Transplantation.

    J. Xu, Y. Zhang, L. Wang, X. Li, R. Chen, R. Zhang, Y. Ding.

    Department of Immunology, Capital Medical University, Beijing, China.

    Background: Development of obliterative bronchiolitis (OB) is the biggest obstacle that limits long-term allograft survival and clinical application of lung transplantation, and the precise mechanisms…
  • 2016 American Transplant Congress

    Heat Shock Protein 90 Inhibitor 17DMAG Is a Potential New Therapeutic Agent Against Acute Allograft Rejection.

    T. Maehana,1 T. Tanaka,1 H. Kitamura,2 N. Masumori.1

    1Urology, Sapporo Medical University School of Medicine, Sapporo, Japan; 2Urology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan.

    Purpose: We have previously demonstrated that Heat shock protein 90 (HSP90) plays a role in the development of acute rejection (AR) in organ transplantation. To…
  • 2016 American Transplant Congress

    Treg-Rich Organized Lymphoid Structures (TOLS) in Spontaneously Accepted Mouse Kidney Allografts.

    C. Yang,1 E. Farkash,2 D. Ndishabandi,1 R. White,1 B. Jiang,1 I. Aljabban,1 P. Russell,1 J. Madsen,1 R. Colvin,1 A. Alessandrini.1

    1Center for Transplantation Sciences, Dept. of Surgery, Dept. of Pathology, Massachusetts General Hospital, Boston, MA; 2University of Michigan School of Medicine, Ann Arbor, MI.

    Background: In many MHC mismatched strain combinations (e.g., DBA/2 to B6) kidney allografts are spontaneously accepted without immunosuppression. This tolerance is regulatory, initially dependent Foxp3+…
  • 2016 American Transplant Congress

    African Americans and Organ Donation: Where Do We Go After Moving from the Bottom to the Top?

    C. Callender,1 N. Koizumi,2 P. Miles,3 J. Melancon.3

    1Department of Surgery, Howard University, Washington, DC; 2School of Policy, Government and Intl Affairs, George Mason University, Arlington, VA; 3Transplant Institute, George Washington University Hospital, Washington, DC.

    PURPOSEThe purpose is to increase organ donation in all ethnic groupsMETHODSThe methodology was based upon the D.C. Organ Donor Program (1982-88) and the Dow Take…
  • 2016 American Transplant Congress

    Rurality Status Does Not Affect Kidney Transplant (KTP) Rates Among Veterans Compared to Medicare, Medicaid, and Private Insurance (PrivIns) Beneficiaries.

    R. Kalil,1,2 C. Franciscus,2 A. O'Shea.1,2

    1Internal Medicine/Nephrology, University of Iowa, Iowa City; 2Comprehensive Access and Delivery Research Evaluation (CADRE), Iowa City VAMC, Iowa City.

    Background: A larger proportion of Veterans live in rural areas compared to non-Veterans. It is unknown whether rural status affects KTP rates among Veterans.Methods: Study…
  • 2016 American Transplant Congress

    Pediatric Critical Care Education Impacts Pediatric Organ Donation.

    D. Lebovitz,1 T. Nakagawa,2 C. Wright.3

    1Critical Care, Akron Children's Hospital, Akron, OH; 2Pediatrics, Wake Forest School of Medicine, Wake Forest, NC; 3Lifelink of Florida, Tampa, FL.

    Objective: Pediatric donation impacts the disparity between organs needed and organs available for transplantation. We evaluated if a regional educational effort on pediatric donation for…
  • 2016 American Transplant Congress

    Deceased Organ Donors with Zero Organs Transplanted: Why and How Can We Improve?

    P. Lange,1 S. Rudich,1 N. Obaseki,1 J. Punch.2

    1Medical Division, Gift of Life Michigan, Ann Arbor, MI; 2Surgery, University of Michigan, Ann Arbor, MI.

    Organ recovery professionals and donor hospitals are under intense pressure to go to whatever lengths necessary to provide transplantable organs. However, such a mentality can…
  • 2016 American Transplant Congress

    A Randomized-Controlled Trial Comparing the Efficacy of CYP3A5 Genotype-Based with Bodyweight-Based Tacrolimus Dosing After Living Donor Kidney Transplantation.

    N. Shuker,1,2 R. Bouamar,2 R. van Schaik,3 M. Clahsen -van Groningen,4 J. Damman,5 C. Baan,1 J. van de Wetering,1 A. Rowshani,1 W. Weimar,1 T. van Gelder,1,2 D. Hesselink.1

    1Internal Medicine, Erasmus Medical Centre, Rotterdam, Netherlands; 2Hospital Pharmacy, Erasmus Medical Centre, Rotterdam, Netherlands; 3Clinical Chemistry, Erasmus Medical Centre, Rotterdam, Netherlands; 4Pathology, Erasmus Medical Centre, Rotterdam, Netherlands; 5Pathology, Academic Medical Centre, Amsterdam, Amsterdam, Netherlands.

    Patients expressing the cytochrome P450 (CYP) 3A5 gene require a higher tacrolimus dose to achieve therapeutic exposure compared with non-expressers. This randomized-controlled study investigated if…
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