Am J Transplant, Volume 16, Suppl 3 Archives - Page 28 of 180 - ATC Abstracts

2016 American Transplant Congress
MELD as a Metric for Survival Benefit of Liver Transplantation.
X. Luo, A. Massie, S. Bae, M. Bowring, D. Segev.
JHU, Baltimore.
MELD predicts waitlist mortality and thus, patients with higher MELD get higher priority in liver allocation. However, this disease severity based allocation system is controversial…
2016 American Transplant Congress
Systematic Review and Meta-Analysis of the Impact of Computed Tomography Assessed Skeletal Muscle Mass on Outcome in Patients Awaiting or Undergoing Liver Transplantation.
J. van Vugt,¹ S. Levolger,¹ R. de Bruin,¹ J. van Rosmalen,² H. Metselaar,³ J. IJzermans.¹
¹Surgery, Erasmus University Medical Center, Rotterdam, Netherlands; ²Biostatistics, Erasmus University Medical Center, Rotterdam, Netherlands; ³Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, Netherlands.
BackgroundAlthough liver transplant outcome has improved significantly, the shortage of human organs remains prevalent. Therefore, strict patient selection is of paramount importance. Recently, low CT-assessed…
2016 American Transplant Congress
Human Leukocyte Antigen (HLA) Mismatch Impact on Lung transplants outcomes.
G. Chery,¹ L. Snyder,¹ M. Durheim,¹ S. Palmer,¹ M. Neely.²
¹Medicine, Duke University School of Medicine, Durham, NC; ²Biostatistics & Bioinformatics, Duke University School of Medicine, Durham, NC.
PurposeReports on the impact of HLA mismatching on survival and its role in the development of bronchiolitis obliterans syndrome (BOS) or chronic allograft lung dysfunction…
2016 American Transplant Congress
Clinical Significance of C3d Binding Donor Specific Anti-HLA Antibodies (DSA) Detected by Single Antigen Beads (SAB) After Kidney Transplantation.
R. Pelletier,¹ I. Balazs,² P. Adams,³ P. Steller,³ N. DiPaola,⁴ L. Rankin,³ A. Diez,⁵ M. Henry.¹
¹Surgery/Transplant, The Ohio State University Wexner Medical Center, Columbus, OH; ²Discovery Research, Immucor, Inc, Stamford, CT; ³Tissue Typing Laboratory, The Ohio State University Wexner Medical Center, Columbus, OH; ⁴Methodist Hospital, Houston, TX; ⁵Nephrology, The Ohio State University Wexner Medical Center, Columbus, OH.
A new Luminex-based SAB method detects DSA compliment fixing via C3d-binding. This study compares the clinical outcomes in kidney recipients that developed de novo DSA…
2016 American Transplant Congress
Antibody-Mediated Rejection Can Be Assessed by Histology When DSA Is Unknown or Negative.
J. Reeve,¹ P. Halloran.²
¹Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; ²Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Diagnosis of antibody-mediated rejection (ABMR) in kidney transplants currently requires the presence of donor-specific antibody (DSA) and histologic lesions above somewhat arbitrary cutoffs. DSA is…
2016 American Transplant Congress
Evaluation of Dose Dependent Rabbit Anti-Thymocyte Globulin Induction in Risk-Stratified Kidney Transplant Recipients.
I. Gutman, M. Misel, D. McKay, A. Hemming, J. Kerr, K. Mekeel.
UC San Diego Health System, San Diego, CA.
Background: Rabbit anti-thymocyte globulin (rATG) is a depleting polyclonal antibody often used for induction following kidney transplantation to help prevent acute rejection. The optimal dosage…
2016 American Transplant Congress
Induction Therapy in Low Risk African American Kidney Transplant Recipients: Donor Factors.
F. Al Ammary,¹ S. Bae,¹ A. Massie,¹ N. Dagher,¹ E. King,¹ A. Wiseman,² D. Segev.¹
¹JHU, Baltimore; ²CU, Denver.
African Americans (AA) are at a higher risk of acute rejection and graft loss compared to non-AA kidney transplant (KT) recipients. Guidelines specify induction choices…
2016 American Transplant Congress
The Environmental Impact of Dialysis vs Transplantation.
M. Grafals,¹ R. Sanchez.²
¹Medstar Georgetown Transplant Institute, Georgetown University, Washington, DC; ²Environmental Health, Harvard University, Boston, MA.
Introduction: Hemodialysis has a large environmental impact because it uses large volumes of water, medical supplies and energy. A patient undergoing weekly dialysis treatment (three…
2016 American Transplant Congress
Mesenchymal Stem Cells Reprogram Macrophage Polarization and Attenuate Liver Ischemia and Reperfusion Injury by Regulating Notch/Cox2/PGE2 Signaling Pathway.
C. Li,¹ S. Yue,¹ R. Busuttil,¹ J. Kupiec-Weglinski,¹ B. Ke.¹
¹The Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA; ²Department of Physiology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Background and aims: Mesenchymal stem cells (MSCs) have been shown an immune modulatory properties and tissue repairing capability under inflammatory conditions. However, it is unknown…
2016 American Transplant Congress
Creation of a Small Animal Model of Ex-Vivo Normothermic Perfusion (EVNP) for Treatment of Kidney Ischemia-Reperfusion (I/R) Injury.
Y. Smolin, I. Palma, C. Pivetti, S. Kabagambe, J. Woloszyn, Y. Chen, T. Boyer, I. Palma, J. Sageshima, C. Santhanakrishnan, R. Perez.
Department of Surgery, UC Davis Medical Center, Sacramento, CA.
Purpose: Recent studies have suggested that EVNP may be utilized to assess and repair marginal donor organs subjected to severe I/R injury. The lack of…