Am J Transplant, Volume 16, Suppl 3 Archives - Page 26 of 180 - ATC Abstracts

2016 American Transplant Congress
Living Donor Kidney Transplant Outcomes Have Improved Over the Last Decade.
A. Nishio Lucar, G. Vranic, D. Keith.
Medicine, University of Virginia, Charlottesville, VA.
Our group recently reported improved 6-month eGFR and long-term patient and allograft outcomes in deceased donor transplant over the last decade. Our goal was to…
2016 American Transplant Congress
Randomized Controlled Study Evaluating Adherence Monitoring with Electronic Feedback on Reducing Renal Allograft Rejection.
A. Bodzin, Y. Becker, M. Josephson, P. Witkowski, M. Lockwood, L. Potter, B. Kane, L. Lourenco, J. Millis.
Transplant Center, University of Chicago, Chicago, IL.
Purpose: The negative impact of non-adherence to the immunosuppressant medication (IM) regimen on transplant outcomes is well recognized. In an attempt to improve outcomes, the…
2016 American Transplant Congress
Clinical Significance of Isolated v1 Arteritis in Renal Transplantation.
D. Mikhail,^1,3 J. Wei,³ D. Kleinsteuber,² M. Gabril,^2,3 A. Sener,^1,3 M. Moussa,^2,3 P. Luke.^1,3
¹Department of Surgery, Division of Urology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; ²Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; ³Undergraduate Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
INTRO: The presence of intimal arteritis (v) in renal transplant biopsies (Bx) establishes Grade II-III AVR (Acute Vascular Rejection) according to the Banff Classification. The…
2016 American Transplant Congress
CD57+ CD4 T Cells Persist in the Periphery Following Kidney Transplantation.
J. Espinosa,^1,2 L. Stempora,¹ R. Townsend,³ A. Kirk.¹
¹Duke University, Durham; ²Emory University, Atlanta; ³Bristol-Meyers Squibb, Princeton.
Purpose: We have shown that CD57+PD1- CD4 T cells play a role in belatacept-resistant rejection, but their mechanism of action is incompletely defined. Potential mechanisms…
2016 American Transplant Congress
Reciprocity for Compatible Pair Participation in Kidney Paired Donation.
J. Gill,¹ M.-C. Fortin,² C. Rose,¹ E. Cole,³ K. Tinckam,³ J. Gill.¹
¹Nephrology, UBC, Vancouver, BC, Canada; ²Nephrology, CHUM, Montreal, QC, Canada; ³Nephrology, UHN, Toronto, ON, Canada.
Participation of ABO and HLA compatible pairs (CPs) in kidney paired donation (KPD) could significantly increase living donor (LD) transplantation (TX). CPs may be more…
2016 American Transplant Congress
Pre-Transplant Cardiovascular Risk Factors Affect Kidney Allograft Survival: A Multi-Center Study in Korea.
J. An,^1,2 S. Ahn,³ E. Bae,² E. Kang,² H.-L. Kim,⁴ Y.-J. Kim,⁵ Y. Oh,^1,2 C. Lim,^1,2 Y. Kim,² Y. Kim,⁶ J. Lee.^1,2
¹Division of Nephrology, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea; ²Division of Nephrology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; ³Department of Preventive Medicine, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do, Korea; ⁴Division of Cardiology, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea; ⁵Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; ⁶Department of Surgery, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Korea.
Background - Pre- or post-transplant cardiovascular (CV) risk factors affect the development of CV events even after successful kidney transplantation (KT). However, the impact of…
2016 American Transplant Congress
KDPI Outcomes and Discard Rates – The Contradiction of the U.S. and European Approach.
L. Lehner, A. Kleinsteuber, F. Halleck, D. Khadzhynov, M. Duerr, K. Budde, O. Staeck.
Dept. of Nephrology CCM, Charite Berlin, Berlin, Germany.
Introduction: Only a few data exist on the KDPI in European patients (pts). We evaluated the influence of donor factors assessed by the KDPI on…
2016 American Transplant Congress
Ibrutinib Suppresses Alloantibody Responses in A Mouse Model of Allosensitization: A Preliminary Report.
G. Wu, I. Kim, N.-N. Chai, A. Klein, S. Jordan.
CTC/Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.
Background Ibrutinib is a Bruton tyrosine Kinase (BTK) antagonist that inhibits B cell receptor (BCR) signaling, therefore blocking B cell activation. Ibrutinib is approved by…
2016 American Transplant Congress
Single Cell Profiling of Th9 Cells Allows Identification of Functionally Different Subsets.
K. Stanko, J. Schumann, K. Vogt, S. Schlickeiser, C. Appelt, B. Sawitzki.
Institute of Medical Immunology, Charite University Medicine, Berlin, Germany.
T helper type 9 (Th9) cells represent a distinct subset of CD4+ effector T cells that is characterized by high secretion of interleukin (IL)-9. Protective…
2016 American Transplant Congress
Effect of Isolated Intraperitoneal Sirolimus Treatment on the Kidneys of C57BL/6 Mice.
B. Kim,^1,3 Y. Cho,³ H. Lee,³ D. Joo,^2,3 K. Huh,^2,3 M. Kim,^2,3 Y. Kim.^2,3
¹Nephrology Division, Department of Internal Medicine, Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea; ²Department of Transplantation Surgery, Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea; ³The Research Institute for Transplantation, Seoul, Republic of Korea.
Sirolimus, a mammalian target of rapamycin inhibitor, is widely used in transplantation. However, the mechanism by which sirolimus induces adverse effects such as proteinuria and…