Am J Transplant, Volume 16, Suppl 3 Archives - Page 19 of 180 - ATC Abstracts

2016 American Transplant Congress
The Prediction of Molecular ABMR by Anti-HLA Donor-Specific Antibody Properties.
F. Eskandary,^1,2 J. Reeve,^1,3 D. Yoo,¹ H. Regele,⁴ L. Hidalgo,^1,3 G. Böhmig,² P. Halloran.^1,5
¹Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada; ²Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria; ³Department of Laboratory Medicine and Pathology, Medical University of Vienna, Vienna, Austria; ⁴Department of Clinical Pathology, Medical University of Vienna, Vienna, Austria; ⁵Department of Medicine, Division of Nephrology and Transplant Immunology, University of Alberta, Edmonton, AB, Canada.
Study purpose: Besides HLA antibody characterization and workup of biopsies (Bx) molecular assessment of gene expression may considerably improve ABMR diagnosis. The objective of the…
2016 American Transplant Congress
Contrasting Effects of Tacrolimus and Everolimus on Regulatory T Cell Activation and Mixed Hematopoietic Chimerism Induced by Natural Killer T Cell Stimulation.
S. Miyairi,^1,2 T. Hirai,¹ R. IShii,¹ M. Okumi,¹ Y. Ishii,³ S. Nunoda,² K. Yamazaki,² K. Tanabe.¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Cardiovascular Surgery, Tokyo Women's Medical University, Tokyo, Japan; ³Laboratory of Vaccine Design, RIKEN IMS-RCAI, Yokohama, Japan.
Calcineurin (CN)-dependent IL-2 production is crucial for regulatory T cells (Tregs) to demonstrate suppressive activity. The mTOR signal is not required for Treg function because…
2016 American Transplant Congress
Decellularized Rat Liver Scaffolds Support Multilineage Xenogenic and Heterogenic Cell Growth.
W. Hassanein, U. Dhru, J. Woodall, M. Uluer, A. Cimeno, D. Parsell, C. Rivera, S. Klepfer, C. Drachenberg, R. Barth, J. LaMattina.
University of Maryland School of Medicine, Baltimore, MD.
Background:Recent years have seen a proliferation of methods leading to successful organ decellularization. Nonetheless, the ability to reproducibly generate a robust recellularized construct remains challenging.…
2016 American Transplant Congress
HCK Is a Potential Mediator of Renal Fibrosis.
C. Wei,¹ M. Menon,¹ L. Li,² Z. Yi,¹ K. Keung,³ C. Woytovich,¹ I. Greene,¹ W. Zhang,¹ J. He,¹ B. Murphy.¹
¹Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY; ²Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY; ³Centre for Transplant and Renal Research, Westmead Millenium Institute, University of Sydney at Westmead Hospital, New South Wales, Australia.
Background: Renal fibrosis is the consequence of excessive accumulation of extracellular matrix that occurs in patients with chronic kidney disease (CKD) and in kidney transplant…
2016 American Transplant Congress
IL-10 Expression of In Vitro Activated B Cells as A Biomarker for B Cell Tolerance.
T. Oura, K. Hotta, K. Crisalli, B. Cosimi, T. Kawai.
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.
Background: A significant role for regulatory B cell has been suggested in kidney transplant recipients who achieved operational tolerance while receiving conventional immunosuppression. We studied…
2016 American Transplant Congress
Infection-Related Mortality After Kidney Transplantation in the Current Era.
I. Helanterä,¹ S. Kinnunen,² P. Karhapää,² A. Juutilainen,² P. Finne.³
¹Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki, Finland; ²Department of Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland; ³Department of Nephrology, Helsinki University Hospital, Helsinki, Finland.
A. Purpose: Infections are the most common non-cardiovascular causes of death after kidney transplantation. We analyzed in detail the current infection-related mortality among kidney transplant…
2016 American Transplant Congress
Outcomes of Liver Grafts from Donors with Very High Transaminases.
P. Martins, A. Rawson, P. Mahboub, B. Movahedi, N. Dolgin, I. Bruggenwirth, A. Bozorgzadeh.
Department of Surgery, Transplant Division, University of Massachusetts, Worcester, MA.
Introduction: Traditionally, elevation of transaminases has been broadly used as markers of hepatic ischemic injury and crucial parameters for liver graft assessment. We wanted to…
2016 American Transplant Congress
Reduced Incidence and Level of De Novo Donor-Specific Antibodies in Belatacept-Treated vs. Cyclosporine-Treated Patients: Final Results from BENEFIT.
R. Bray,¹ H. Gebel,¹ R. Townsend,² M. Polinsky,² L. Yang,² U. Meier-Kriesche,² C. Larsen.¹
¹Emory University, Atlanta, GA; ²Bristol-Myers Squibb, Lawrenceville, NJ.
Background: The presence of donor-specific antibodies (DSA) has been associated with an increased risk of antibody-mediated rejection and graft failure. Mean fluorescence intensity (MFI) is…
2016 American Transplant Congress
Factors Predicting Risk for Antibody-Mediated Rejection in Highly Sensitized Pediatric Renal Transplants.
I. Kim,¹ J. Choi,¹ A. Vo,¹ S. Louie,¹ J. Mirocha,² S. Jordan,¹ E. Kamil,¹ D. Puliyanda.¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Biostatistics Core, Cedars-Sinai Medical Center, Los Angeles, CA.
Introduction: Antibody-mediated rejection (ABMR) is a concern in highly sensitized (HS) patients (pts) receiving renal transplant (tx). We have previously published that a donor specific…
2016 American Transplant Congress
Evaluating the Influence of Liver Donor and Recipient Race on Tacrolimus Dose Requirements.
J. Knorr, J. Vidal, V. Navarro, R. Zaki.
Einstein Medical Center, Philadelphia, PA.
Background: The majority of liver transplant recipients (LTR) receive tacrolimus (TAC) to prevent allograft rejection. Early establishment of therapeutic levels is imperative to efficacy. Several…