Am J Transplant, Volume 16, Suppl 3 Archives - Page 172 of 180 - ATC Abstracts

2016 American Transplant Congress
Standardized Pre-Implantation Kidney Biopsies of Expanded Criteria Donors to Improve the Kidney Donor Profile Index (KDPI) for the Evaluation of Marginal Donors.
A. Sánchez-Escuredo,¹ A. Sagasta,² F. Diekmann,¹ I. Revuelta,¹ L. Rodas,¹ D. Paredes,³ M. Musquera,⁴ N. Esforzado,¹ M. Ricart,¹ F. Cofan,¹ V. Torregrosa,¹ J. Campistol,¹ M. Sole,² F. Oppenheimer.¹
¹Nephrology and Renal Transplant, Hospital Clínic, Barcelona, Spain; ²Pathology, Hospital Clínic, Barcelona, Spain; ³Transplant Foundation, Hospital Clínic, Barcelona, Spain; ⁴Urology, Hospital Clínic, Barcelona, Spain.
There is no consensus of selection criteria used to allocate renal transplants from expanded criteria donors (ECD). The Kidney Donor Profile Index (KDPI) has been…
2016 American Transplant Congress
Eary Use of Statins Associated with Improved Death-Censored Graft Survival Following Kidney Transplant.
T. Horwedel,¹ D. Brennan,² K. Lentine,³ J. Hagopian.¹
¹Barnes-Jewish Hospiptal, St. Louis, MO; ²Washington University School of Medicine, St. Louis, MO; ³St. Louis University, MO.
Purpose: The impacts of statin therapy on patient and graft outcomes after kidney transplantation (KT) are controversial.Methods: We performed a retrospective cohort study of adult…
2016 American Transplant Congress
CD9+ Regulatory B Lymphocytes Control Chronic Lung Inflammation by Inducing Effector T Cell Apoptosis.
C. Brosseau,^1,2 M. Durand,¹ F. Braza,¹ E. Durand,² J. Loy,² P. Lacoste,² P. Royer,² M.-A. Cheminant,² A. Magnan,² S. Brouard.¹
¹ITUN-INSERM U1064, Nantes, France; ²Institut du thorax, INSERM U1087/CNRS U6291, Nantes, France.
Several observations highlight the relevance of regulatory B cells (Breg) to clinical transplantation. We have identified a new Breg population expressing the CD9, able to…
2016 American Transplant Congress
Pathogenic Role of Anti-HLA Antibodies on Endothelial Progenitor Cell Dysfunction of Highly Sensitized Kidney Transplanted Patients.
V. Cantaluppi,¹ S. Dellepiane,² D. Medica,² G. Tognarelli,² M. Quaglia,¹ C. Musetti,¹ A. Airoldi,¹ L. Biancone.²
¹Nephrology, Dialysis and Kidney Transplantation Unit, University of Eastern Piedmont "A. Avogadro", Novara, Italy; ²Nephrology, Dialysis and Kidney Transplantation Unit, University of Torino, Torino, Italy.
Anti-HLA antibodies (abs) bind to kidney graft endothelial cells inducing complement-mediated injury and humoral rejection. Endothelial Progenitor Cells (EPC) are bone marrow-derived precursors able to…
2016 American Transplant Congress
Soluble Fibrinogen-Like Protein 2 Regulates Differentiation and Enhances Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Allograft Immunity.
C. Yang,^1,4 L. Wang,³ R. Rong,^2,4 T. Zhu,^2,4 M. Xu.^2,4
¹Plastic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China; ²Urology, Zhongshan Hospital, Fudan University, Shanghai, China; ³Biomedical Research Center, Zhongshan Hospital, Fudan University, Shanghai, China; ⁴Shanghai Key Laboratory of Organ Transplantation, Shanghai, China.
Soluble fibrinogen-like protein 2 (sFGL2) is a novel immunoregulatory molecule, secreted mainly by regulatory T cells. CD11b+ Gr1+ myeloid-derived suppressor cells (MDSCs) are an important…
2016 American Transplant Congress
Early De Novo DSA with T Cell Mediated Rejection (TCMR) Is Associated with Allograft Dysfunction with Chronic Injury.
A. Cherukuri, R. Mehta, P. Sood, A. Zeevi, S. Hariharan, D. Rothstein.
UPMC, Pittsburgh.
De novo anti-donor HLA specific antibody (DSA) detected post-renal transplantation is associated with adverse outcomes. However, the relationship between early de novo DSA and subsequent…
2016 American Transplant Congress
Evolving to Everolimus: A Safe and Effective Option for Pancreas Transplant.
S. Yeager, A. Carlson, C. Truax, N. Kenyon, F. Ahmed, J. Corbett, F. Shihab, L. Smith.
University of Utah Health Care, Salt Lake City, UT.
Although everolimus is an attractive option for conversion therapy in pancreas tx pts that experience SE's of commonly used immunosuppression, TAC and MPA, there is…
2016 American Transplant Congress
Risk Factors for Early Readmission After Total Pancreatectomy with Islet Auto Transplantation.
R. Shahbazov,¹ N. Bashoo,² G. Yoshimatsu,² G. Saracino,² F. Azari,¹ N. Onaca,² P. Kim,² M. Levy.³
¹Charles O.Strikler Transplant Center, Department of Surgery, University of Virginia, Charlottesville, VA; ²Baylor Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX; ³Transplant Division, Virginia Commonwealth University, Richmond, VA.
Introduction: Readmission after Total Pancreatectomy with Islet Auto Transplantation (TPIAT) is common, but no data is available on reasons for readmission and islet graft function.Aims:…
2016 American Transplant Congress
Developing a PCR-Based System to Access the Correlation of Local Chimerism and Fate of the Vascularized Composite Allotransplant.
X.-T. Huang,¹ H.-Y. Cheng,¹ C.-F. Lin,¹ S.-S. Qiu,² L.-Y. Shih,¹ F.-C. Wei.^1,2,3
¹Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Gueishan, Taoyuan, Taiwan; ²Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Gueishan, Taoyuan, Taiwan; ³College of Medicine, Chang Gung University, Gueishan, Taoyuan, Taiwan.
It is established that development of mixed chimerism following allotransplantation is associated with induction of tolerance to allotransplants. Although chimerism in peripheral blood can be…
2016 American Transplant Congress
Measuring Efficacy of Antibody Removal Therapies: Back to Titers.
A. Tambur,¹ D. Glotz,² N. Herrera,¹ E. Chatroop,¹ T. Roitberg,¹ J. Friedewald,¹ D. Gjertson.³
¹Northwestern University, Chicago; ²Hopital Saint-Louis, Paris, France; ³UCLA, LA.
The need for reliable tools to predict likelihood of HLA-antibody responses to treatment and to monitor efficacy of antibody removal therapies manifests itself on two…