Date: Sunday, June 12, 2016
Session Name: Poster Session B: Disparities in Access and Outcomes
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Halls C&D
End-stage renal disease (ESRD) patients with sickle cell nephropathy (SCN) are less likely to receive a kidney transplant (KT) than ESRD patients without SCN. Comparing patient survival among SCN patients who receive a KT to that of SCN patients who remain on the waitlist for a KT may improve understanding of KT survival benefit in this population.
Methods: Using SRTR data on all US-based adults with SCN who were placed on the KT waitlist between 1998 and 2015, we performed time-dependent Cox regression models with adjustment for patient demographic characteristics to compare relative mortality in candidates who received a KT versus candidates who remained on the waitlist.
Results: There were 540 SCN patients on the KT waitlist, of whom 53.7% were male and 93.1% were black with a mean age of 38.5 years. 24.2% of candidates received a KT. In the first three years post-transplant, mortality in KT recipients was 72% lower than in candidates who remained on the waitlist (aHR: 0.28, 95% CI: 0.12-0.63, p=0.002). After three years post-transplant, mortality in KT recipients was 55% lower than in candidates who remained on the waitlist (aHR: 0.45, 95% CI: 0.28-0.72, p=0.001). (Figure 1)
Conclusions: KT is associated with better short and long-term survival in adults with SCN. Efforts to improve timely assessments for transplant-eligibility by nephrologists and to increase rates of KT among SCN patients will help to reduce mortality in this disparity population.
CITATION INFORMATION: Purnell T, Luo X, Bae S, Massie A, Segev D. Survival Benefit of Kidney Transplantation in US Adults with Sickle Cell Nephropathy. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:Purnell T, Luo X, Bae S, Massie A, Segev D. Survival Benefit of Kidney Transplantation in US Adults with Sickle Cell Nephropathy. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/survival-benefit-of-kidney-transplantation-in-us-adults-with-sickle-cell-nephropathy/. Accessed March 4, 2021.
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