ATC Abstracts

American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    Novel Nuclear Factor-κB Activation Inhibitor, Dehydroxymethylepoxyquinomicin, Prevents the Development of Chronic Cyclosporine Nephropathy in Rats.

    S. Morita,1 K. Shinoda,1 S. Tamaki,1 H. Kono,2 Y. Kanno,3 K. Umezawa,4 K. Nakagawa,2 M. Oya.1

    1Urology, Keio University School of Medicine, Tokyo, Japan; 2Urology, Tokyo Dental College Ichikawa General Hospital, Ichikawa, Chiba, Japan; 3Nephrology, Tokyo Medical University, Tokyo, Japan; 4Molecular Target Medicine Screening, Aichi Medical University, Nagakute, Aichi, Japan.

    Purpose:The nephrotoxicity of the calcineurin inhibitors including cyclosporine is a major problem in the kidney transplantation. We investigated the effect of a novel nuclear factor-κB…
  • 2016 American Transplant Congress

    Three Months of Weekly Rifapentine Plus Isoniazid for Latent Tuberculosis Treatment in Solid Organ Transplant Candidates.

    B. Knoll,1 R. Nog,1 Y. Wu,2 A. Dhand.1

    1Medicine, Division of Infectious Diseases, Westchester Medical Center, Valhalla, NY; 2Division of Transplant and Hepatobiliary Surgery, Westchester Medical Center, Valhalla, NY.

    Purpose: Although isoniazid 300 mg daily for 9 months is the recommended regimen for latent tuberculosis infection (LTBI) in solid organ transplant (SOT) candidates, its…
  • 2016 American Transplant Congress

    Clinical Risk Factors for the Recurrence of Clostridium difficile Infection (CDI) in Solid Organ Transplant Recipients (SOTR).

    Y. Natori, M. Shiotsuka, L. Oen, E. Renner, L. Singer, J. Kim, H. Ross, D. Kumar, C. Rotstein, A. Humar, S. Husain.

    Multi-Organ Transplant, University Health Network, Toronto, ON, Canada.

    Introduction:CDI is a common complication in SOTR. Recurrence may occur after treatment of the initial episode. However, the clinical risk factors of the recurrence of…
  • 2016 American Transplant Congress

    First Experience with Obinutuzumab (Type II Anti-CD20) in Patients with Treatment-Resistant Glomerular Diseases and Antibody-Mediated Rejection.

    J. Choi, S. Jordan, A. Vo.

    Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.

    Introduction: There is extensive experience with rituximab (RTX,Type I anti-CD20) for desensitization (DES) and treatment of ABMR. There is also a comparable experience in treatment…
  • 2016 American Transplant Congress

    Belatacept Conversion in Adult Kidney Transplant Recipients for Cause: A Single Center Observational Cohort.

    M. Savic,1 M. Cruz,2 A. Rossi,1 J. Vella.1

    1Maine Transplant Program, Maine Medical Center, Portland, ME; 2University of Connecticut, Storrs, CT.

    Background: Calcineurin inhibition (CNI) is the single most effective strategy to prevent allograft rejection however tolerability is limited by toxicity. To date, alternate strategies have…
  • 2016 American Transplant Congress

    Donor-Specific Antibodies in a Single-Center Pediatric Kidney Transplant Population – Incidence and Risk Factors.

    M. Bock,1 L. Starkey,1 C. Buchanan,2 E. Steinberg,2 A. Sikora,2 K. McKinnon,2 M. Wachs,2 J. Goebel.1

    1Transplant Surgery, Children's Hospital Colorado, Aurora, CO; 2Pediatric Nephrology, Children's Hospital Colorado, Aurora, CO.

    In mid-2015, we implemented donor-specific antibody (DSA) monitoring in our pediatric kidney transplant recipient (pKTR) population as recommended (Transplantation 2013;95:19-). We now cross-sectionally analyzed our…
  • 2016 American Transplant Congress

    A Retrospective Analysis of Rabbit Antithymocyte Globulin Dosing, MELD, Race, and Weight on Infection and Rejection Rates in Liver Transplantation.

    R. Imai, U. Wang.

    Department of Pharmacy, Stanford Health Care, Stanford, CA.

    INTRODUCTION: Rabbit antithymocyte globulin (rATG) use in liver transplantation is uncommon. At our center, induction therapy is comprised of rATG dosed at 1 – 2…
  • 2016 American Transplant Congress

    Ideal Outcome After Liver Transplantation: An Exploratory Study Using Machine Learning Analyses to Leverage Long-Term Registry Data from Studies in Pediatric Liver Transplantation (SPLIT).

    E. Hsu,1 M. Shaffer,1,2 R. Anand,3 V. Ng,4 J. Bucuvalas.5

    1University of Washington School of Medicine, Seattle, WA; 2Children's Core for Biomedical Statistics, Center for Clinical and Translational Research, Seattle Children's Hospital, Seattle, WA; 3The EMMES Corporation, Rockville, MD; 4The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada; 5Cincinnati Children's Hospital and Medical Center, Cincinnati, OH.

    We analyzed the Studies in Pediatric Liver Transplantation (SPLIT) registry dataset using heat map and random forests analyses (RFA) to determine if ideal outcome (IO)…
  • 2016 American Transplant Congress

    Liver Transplantation for Propionic Acidemia: A Review of the United States Scientific Registry for Transplant Recipients (SRTR) and Non-US Case Series.

    N. Celik, K. Soltys, G. Bond, Q. Sun, G. Vockley, R. Sindhi, G. Mazariegos.

    Surgery, Childrens Hospital of Pgh, Pittsburgh.

    Background: A fifth of all pediatric liver transplants in the US are performed for metabolic disease. Propionic acidemia, an autosomal recessive branched chain organic acidemia…
  • 2016 American Transplant Congress

    Increased Gene Expression of TGF-β in Peripheral Blood Mononuclear Cells from Renal Transplant Patients with Polyomavirus BK Viremi.

    W. Yin,1 M. Lu.2

    1Surgery, School of Medicine, Tzu Chi University, Hualien, Taiwan, Division of General Surgery, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chia-I, Dalin, Taiwan; 2Allergy, Immunology and Rheumatology, School of Medicine, Tzu Chi University, Hualien, Taiwan, Division of Allergy, Immunology and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chia-I, Dalin, Taiwan.

    We aimed to investigate the roles of cytokines during polyomavirus BK (BKV) reactivation in renal transplant patients. Forty-eight renal allograft recipients were enrolled in this…
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