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Pre-Transplant Cardiovascular Risk Factors Affect Kidney Allograft Survival: A Multi-Center Study in Korea.

J. An,1,2 S. Ahn,3 E. Bae,2 E. Kang,2 H.-L. Kim,4 Y.-J. Kim,5 Y. Oh,1,2 C. Lim,1,2 Y. Kim,2 Y. Kim,6 J. Lee.1,2

1Division of Nephrology, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea
2Division of Nephrology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
3Department of Preventive Medicine, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do, Korea
4Division of Cardiology, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea
5Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
6Department of Surgery, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Korea.

Meeting: 2016 American Transplant Congress

Abstract number: B212

Keywords: Graft survival, Kidney transplantation, Risk factors, Vascular disease

Session Information

Date: Sunday, June 12, 2016

Session Name: Poster Session B: Kidney: Cardiovascular and Metabolic

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Halls C&D

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Background – Pre- or post-transplant cardiovascular (CV) risk factors affect the development of CV events even after successful kidney transplantation (KT). However, the impact of pre-transplant CV risk factors on allograft failure (GF) has not been reported.

Methods and Results – We analyzed the graft outcomes of 2,902 KT recipients who were enrolled in a multi-center cohort from 1997 to 2012. We calculated the pre-transplant CV risk scores based on the Framingham risk model using age, gender, total cholesterol level, smoking status, and history of hypertension. Vascular disease (a composite of ischemic heart disease, peripheral vascular disease, and cerebrovascular disease) was noted in 6.5% of the patients. During the median 6.4 years follow-up, 122 (4.2%) patients had died and 286 (9.9%) patients had developed GF. In the multivariable-adjusted Cox proportional hazard model, pre-transplant vascular disease was associated with an increased risk of GF (HR 2.51; 95% CI 1.66-3.80). The HR for GF (comparing the highest with the lowest tertile regarding the pre-transplant CV risk scores) was 1.65 (95% CI 1.22-2.23). In the competing risk model, both pre-transplant vascular disease and CV risk score were independent risk factors for GF. Moreover, the addition of the CV risk score, the presence of vascular disease, or both had a better predictability for GF compared to the traditional GF risk factors.

Conclusions – Both vascular disease and pre-transplant CV risk score were independently associated with GF in this multi-center study. Pre-transplant CV risk assessments could be useful in predicting GF in KT recipients.

CITATION INFORMATION: An J, Ahn S, Bae E, Kang E, Kim H.-L, Kim Y.-J, Oh Y, Lim C, Kim Y, Kim Y, Lee J. Pre-Transplant Cardiovascular Risk Factors Affect Kidney Allograft Survival: A Multi-Center Study in Korea. Am J Transplant. 2016;16 (suppl 3).

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To cite this abstract in AMA style:

An J, Ahn S, Bae E, Kang E, Kim H-L, Kim Y-J, Oh Y, Lim C, Kim Y, Kim Y, Lee J. Pre-Transplant Cardiovascular Risk Factors Affect Kidney Allograft Survival: A Multi-Center Study in Korea. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/pre-transplant-cardiovascular-risk-factors-affect-kidney-allograft-survival-a-multi-center-study-in-korea/. Accessed March 4, 2021.

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