ATC Abstracts

American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    Increasing Tacrolimus Time-in-Therapeutic Range Is Associated with Less Cellular Rejection in Lung Transplant Recipients.

    C. Ensor, K. Harrigan, R. Venkataramanan, M. Morrell, C. Moore, J. Hayanga, M. Crespo, J. DCunha, A. Zeevi, J. McDyer.

    University of Pittsburgh, Pittsburgh, PA.

    Purpose: To describe the effect of tacrolimus (FK) time-in-therapeutic range (TTR) on incidence of cellular rejection (ACR) within the first year after lung transplantation (LT).Methods:…
  • 2016 American Transplant Congress

    Serelaxin Decreases the Severity of Cold Ischemia-Reperfusion Injury After Liver Transplantation in Mice.

    S. Kageyama, K. Nakamura, R. Busuttil, J. Kupiec-Weglinski.

    The Dumont-UCLA Transplantation Center, UCLA, Los Angeles, CA.

    Background. Extended cold preservation contributes to ischemia-reperfusion injury (IRI), which impairs graft function and leads to poor clinical outcomes. Serelaxin (SER), a recombinant form of…
  • 2016 American Transplant Congress

    Prevalence of Polyreactive Innate-Like B Cells Among Graft-Infiltrating B Cells in Human Cardiac Allograft Vasculopathy.

    D. Chatterjee,1 C. Moore,2 B. Gao,3 K. Clerkin,1 S. See,1 D. Shaked,1 K. Rogers,1 S. Nunez,1 Y. Veras,1 L. Addonizio,1 M. Givertz,4 Y. Naka,1 D. Mancini,1 R. Vasilescu,5 C. Marboe,5 S. Restaino,1 J. Madsen,2 E. Zorn.1

    1Medicine, Columbia University Medical Center, NY, NY; 2Massachusetts General Hospital Transplant Center, Boston; 3First Hospital of Jilin University, Changchun, China; 4Brigham and Women's Hospital, Boston; 5Pathology & Cell Biology, Columbia University Medical Center, NY.

    Cardiac allograft vasculopathy (CAV) is a leading cause of death in long-term heart transplant survivors. Dense B cell infiltrates are common in heart transplants with…
  • 2016 American Transplant Congress

    Criteria for the Diagnosis of Microvascular Inflammation (MVI) in Kidney Transplant Biopsies (KTxBx).

    J. Grande,1 R. Leduc,2 The DeKAF Study Group.

    1Dept. of Lab Medicine & Pathology, Mayo Clinic College of Medicine, Rochester, MN; 2Division of Biostatistics, U. Minnesota School of Public Health, Minneapolis, MN.

    The presence of MVI (Banff glomerulitis "g" score and Banff peritubular capillary "ptc" score) in KTxBx, often related to antibody mediated rejection (AMR), is associated…
  • 2016 American Transplant Congress

    Impact of Machine Perfusion on Long-Term Kidney Transplant Outcomes.

    S. Sandal,1,2 X. Luo,2 A. Massie,2 M. Cantarovich,1 D. Segev.2

    1MUHC, Montreal, Canada; 2JHU, Baltimore.

    Machine perfusion (MP) has been shown to decrease DGF rates in kidney transplant (KT) recipients when compared with static cold storage (CS). However, there is…
  • 2016 American Transplant Congress

    Complement-Binding Donor-Specific Anti-HLA Antibodies Are Associated with Severe Kidney Allograft Arteriosclerosis.

    A. Loupy,1 D. Viglietti,2 J. Duong Van Huyen,1 D. Glotz,2 C. Legendre,1 A. Zeevi,3 C. Lefaucheur.2

    1Necker Hospital, Paris, France; 2Saint-Louis Hospital, Paris, France; 3University of Pittsburgh Medical Center, Pittsburgh.

    The role of circulating donor-specific anti-HLA antibodies (DSA) in the development of accelerated arteriosclerosis have been recently reported in kidney transplant recipients. This study investigated…
  • 2016 American Transplant Congress

    An Economical and Effective Vaccination Program in Patients Transplanted for Hepatitis B Virus Related Liver Diseases: A Prospective Study.

    W. Ju, A. Yang, Q. Ren, D. Wang, Z. Guo, Y. Ma, A. Hu, Q. Tai, X. Zhu, X. He.

    Organ Transplantation Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

    Aims: To prospectively investigate the efficacy and safety of procedural HBV vaccination in patients transplanted for HBV related liver diseases for prevention of hepatitis B…
  • 2016 American Transplant Congress

    Renal Outcome with Eculizumab in Patients with aHUS with Native and Transplanted Kidneys: Pooled Analysis of 100 Patients.

    C. Legendre,1 J. Campistol,2 T. Feldkamp,3 J. Wang,4 G. Remuzzi,5 L. Weekers,6 N. Sheerin.7

    1Université Paris Descartes & Hôpital Necker, Paris, France; 2Hospital Clinic, University of Barcelona, Barcelona, Spain; 3University Hospital Schleswig-Holstein, Kiel, Germany; 4Alexion Pharmaceuticals, Inc., Cheshire, CT; 5IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy; 6CHU de Liège, Liège, Belgium; 7Newcastle University, Newcastle upon Tyne, United Kingdom.

    Purpose: aHUS often progresses to ESRD and requires transplant (tx). Eculiumab (ECU), a terminal complement inhibitor, inhibits TMA irrespective of tx status. We evaluated outcomes…
  • 2016 American Transplant Congress

    Factors Associated with Acute Rejections in Kidney Transplant Recipients: Time for HLA-DR Matching in Elderly Recipients?

    D. Khadzhynov, F. Halleck, L. Lehner, M. Duerrr, A. Kleinsteuber, D. Schmidt, K. Budde, O. Staeck.

    Nephrology, Charite Universitaetsmedizin, Berlin, Germany.

    Background. Within the Eurotransplant Senior Allocation Program (ESP) HLA-matching is neglected,potentially causing inferior outcomes. There is a lack of data analysing the long-term immunologic outcomes…
  • 2016 American Transplant Congress

    Significant Association of Vitamin-D Receptor (VDR) Gene Polymorphism and Incidence of De Novo DSA in Renal Transplantation.

    L. Das, K. Ide, Y. Tanaka, N. Tanimine, S. Verma, H. Ohdan.

    Department of Gastroenrological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.

    Objective-Renal Transplantation (RT) is the optimal choice forend stage renal disease. Despite all advances in the development ofeffective immunosuppressive regimens in renal transplantation one of…
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