Am J Transplant, Volume 16, Suppl 3 Archives - Page 164 of 180 - ATC Abstracts

2016 American Transplant Congress
Early Post-Transplant Patient, Graft Survival and Rejection Rates Under KAS.
A. Kucheryavaya, D. Stewart, D. Klassen.
UNOS, Richmond.
Background: KAS, implemented on 12/4/14, resulted in changes in recipient, donor/recipient and tx characteristics that have the potential to affect post-tx outcomes.Data and Methods: We…
2016 American Transplant Congress
Primary Outcome of iWITH: A Multi-Center Clinical Trial of Complete Immunosuppression Withdrawal (ISW) in Stable Pediatric Liver Transplant (LT) Recipients.
S. Feng,¹ J. Bucuvalas,² A. Demetris,³ K. Spain,⁴ S. Kanaparthi,⁵ J. Magee,⁶ G. Mazariegos,³ The iWITH Investigators.⁷
¹UCSF, San Francisco; ²CCHMC, Cincinnati; ³U Pitt, Pittsburgh; ⁴Rho, Chapel Hill; ⁵ITN, Bethesda; ⁶U Mich, Ann Arbor; ⁷NIAID/NIDDK/ITN, Bethesda.
AIM: Test the hypothesis that a selected cohort of pediatric LT recipients can safely undergo complete ISW followed by assessment for operational tolerance (OT)METHODS: 88…
2016 American Transplant Congress
Skipping Comparable Local Waitlist Candidates Under Share 35.
E. Chow,¹ A. Massie,¹ X. Luo,¹ C. Wickliffe,¹ S. Gentry,² A. Cameron,¹ D. Segev.¹
¹Surgery, Johns Hopkins University, Baltimore, MD; ²Mathematics, US Naval Academy, Annapolis, MD.
Under Share-35, deceased donor (DD) livers are offered regionally to candidates with MELD≥35 before locally to lower MELD candidates. The characteristics and outcomes of local…
2016 American Transplant Congress
Are We Refusing Good Organs? Outcomes of Ventilator Management of Sub-Optimal Lung Donors.
B. Scully,¹ D. Horne,¹ J. Heinle,¹ E. McKenzie,¹ K. Hosek,² W. Zhang,² G. Mallory,³ E. Melicoff.³
¹Congenital Heart Surgery, Texas Children's Hospital, Houston, TX; ²Outcomes and Impact Services, Texas Children's Hospital, Houston, TX; ³Pulmonology, Texas Children's Hospital, Houston, TX.
PurposeOptimizing donor lung function is essential for organ acceptance and successful lung transplantation (LTx). We hypothesized that ventilator management of sub-optimal donor lungs, PaO2<300 mmHg,…
2016 American Transplant Congress
High Incidence of Herpes Zoster After Kidney, Liver, Heart and Lung Transplantation.
N. van Besouw, S. Roest, D. Bovée, H. Metselaar, R. Hoek, J. van Weezel, A. van der Eijk, W. Weimar, O. Manintveld, M. Kho.
Erasmus MC, Rotterdam, Netherlands.
Background: Primary varicella zoster virus (VZV) infection causes varicella and lifelong latent infection in neural ganglia from which it may reactivate leading to herpes zoster…
2016 American Transplant Congress
Solid Phase Assay Demonstrates High Rates of Allosensitization in Pediatric Heart Recipients.
W. Zuckerman,¹ B. Feingold,² A. Zeevi,² C. Bentlejewski,² L. Addonizio,¹ E. Blume,³ C. Canter,⁴ A. Dipchand,⁵ D. Hsu,⁶ R. Shaddy,⁷ W. Mahle,⁸ K. Much,⁹ B. Armstrong,⁹ D. Ikle,⁹ H. Diop,¹⁰ J. Odim,¹⁰ S. Webber.¹¹
¹Columbia Univ., NYC; ²Univ. of Pittsburgh, Pittsburgh; ³Boston Children's Hospital, Boston; ⁴Washington Univ., St. Louis; ⁵Sick Kids, Toronto, Canada; ⁶Children's Hospital, Montefiore, NYC; ⁷Children's Hospital of Philadelphia, Philadelphia; ⁸CHOA, Atlanta; ⁹Rho, Chapel Hill; ¹⁰NIAID/NIH, Bethesda; ¹¹Vanderbilt Univ., Nashville.
Allosensitization is a risk factor for rejection, vasculopathy and graft loss. CTOTC-04 is a prospective study assessing the impact of sensitization on a composite of…
2016 American Transplant Congress
T-Bet Regulates nTreg Stability and Suppression in an Islet Allograft Model.
Y. Xiong, S. Ahmad, D. Iwami, C. Brinkman, J. Bromberg.
University of Maryland, Baltimore.
The transcription factor T-bet endows Treg with properties tosuppress Th1 inflammation. However, the mechanisms by which T-bet controls alloimmune responses are not fully understood. We…
2016 American Transplant Congress
A Novel Murine Orthotopic Forelimb Transplantation Model That Allows for Reliable Assessment of Post-Transplant Upper Extremity Function.
J. Budihardjo,¹ B. Kern,^1,2 S. Mermulla,¹ A. Quan,¹ C. Cadmi,¹ J. Lopez,¹ J. Park,¹ A. Hoke,¹ W. Lee,¹ S. Tuffaha,¹ G. Brandacher.¹
¹Plastic Surgery, Johns Hopkins Medical Institutions, Baltimore, MD; ²Transplant Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Background: Studies related to functional return for upper extremity transplantation have been limited by the lack of a functional VCA animal model. The rat hindlimb…
2016 American Transplant Congress
The Role of PI3kγ and PI3kδ in Alloimmunity.
M. Uehara,¹ A. Jamil,¹ Z. Solhjou,¹ M. McGrath,¹ N. Banouni,¹ C. Evans,² J. Dinitto,² D. Winkler,² R. Abdi.¹
¹Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ²Infinity Pharmaceuticals, Inc, Boston.
We studied the role of phosphatidylinositol-3-kinases (PI3k) γ and δ pathway in alloimmunity. Generated Foxp3-GFP-PI3kγ and -PI3kδ knockout mice (C57BL/6 background) were used in heart…
2016 American Transplant Congress
Aquaporin 4 Blockade Is a Novel Strategy to Prevent T Cell Activation and Effector Functions.
K. Ayasoufi,¹ N. Kohei,¹ G. Farr,² P. McGuirk,² M. Pelletier,² R. Fairchild,¹ A. Valujskikh.¹
¹Cleveland Clinic, Cleveland; ²Aeromics LLC, Cleveland.
Aquaporin 4 (AQP4) belongs to the family of integral transmembrane proteins highly permeable to water. We have previously reported that blocking AQP4 with small molecule…