ATC Abstracts

American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    Immediate Introduction of Everolimus Does Not Affect Wound Healing and Delayed Graft Function in Kidney Transplant Recipients: 3-Months Results from NEVERWOUND Study.

    M. Carmellini,1 P. Todeschini,2 A. Secchi,3 S. Sandrini,4 E. Minetti,5 L. Furian,6 G. Spagnoletti,7 F. Pisani,8 G. Piredda,9 G. Cappelli,10 G. Tisone.11

    1AOU Senese, Siena, Italy; 2AOP S.Orsola-Malpighi, Bologna, Italy; 3Osp San Raffaele IRCCS, Milano, Italy; 4AO Spedali Civili, Brescia, Italy; 5AOU Careggi, Firenze, Italy; 6AOU di Padova, Padova, Italy; 7PU A.Gemelli, Roma, Italy; 8POU S.Salvatore, L'Aquila, Italy; 9AO G.Brotzu, Cagliari, Italy; 10AOUP di Modena, Modena, Italy; 11Fondazione PU Tor Vergata, Roma, Italy.

    The NEVERWOUND study was designed to evaluate the impact of immediate vs. delayed introduction of everolimus (EVR) on wound healing complications (WHC) and delayed graft…
  • 2016 American Transplant Congress

    Denosumab Prevents Bone Mineral Density Loss in De Novo Kidney Transplant Recipients: Results from a Randomized Controlled Trial.

    M. Bonani,1 D. Frey,2 J. Brockmann,3 T. Fehr,1 T. Müller,1 N. Graf,4 R. Wüthrich.1

    1Division of Nephrology, University Hospital Zurich, Zurich, Switzerland; 2Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland; 3Division of Visceral and Transplantation Surgery, University Hospital Zurich, Zurich, Switzerland; 4Graf Biostatistics, Winterthur, Switzerland.

    Background: Kidney transplantation is associated with bone loss and an increased risk of fracture. Since current therapeutic options to prevent bone loss are limited we…
  • 2016 American Transplant Congress

    Associations of Risk Factors and Kidney Retransplant Outcomes Vary Between Three Common Induction Agents: Results from the Analysis of Over Ten-Thousand Cases in Ten Years.

    A. Santos, X. Wen, M. Casey, S. Rehman, K. Womer.

    Medicine, University of Florida, Gainesville, FL.

    BACKGROUND: There is no published study comparing the significance of risk factors for graft outcomes associated with common induction regimens combined with tacrolimus and mycophenolate…
  • 2016 American Transplant Congress

    Increasing Tacrolimus Time-in-Therapeutic Range Is Associated with Less Cellular Rejection in Lung Transplant Recipients.

    C. Ensor, K. Harrigan, R. Venkataramanan, M. Morrell, C. Moore, J. Hayanga, M. Crespo, J. DCunha, A. Zeevi, J. McDyer.

    University of Pittsburgh, Pittsburgh, PA.

    Purpose: To describe the effect of tacrolimus (FK) time-in-therapeutic range (TTR) on incidence of cellular rejection (ACR) within the first year after lung transplantation (LT).Methods:…
  • 2016 American Transplant Congress

    Serelaxin Decreases the Severity of Cold Ischemia-Reperfusion Injury After Liver Transplantation in Mice.

    S. Kageyama, K. Nakamura, R. Busuttil, J. Kupiec-Weglinski.

    The Dumont-UCLA Transplantation Center, UCLA, Los Angeles, CA.

    Background. Extended cold preservation contributes to ischemia-reperfusion injury (IRI), which impairs graft function and leads to poor clinical outcomes. Serelaxin (SER), a recombinant form of…
  • 2016 American Transplant Congress

    Prevalence of Polyreactive Innate-Like B Cells Among Graft-Infiltrating B Cells in Human Cardiac Allograft Vasculopathy.

    D. Chatterjee,1 C. Moore,2 B. Gao,3 K. Clerkin,1 S. See,1 D. Shaked,1 K. Rogers,1 S. Nunez,1 Y. Veras,1 L. Addonizio,1 M. Givertz,4 Y. Naka,1 D. Mancini,1 R. Vasilescu,5 C. Marboe,5 S. Restaino,1 J. Madsen,2 E. Zorn.1

    1Medicine, Columbia University Medical Center, NY, NY; 2Massachusetts General Hospital Transplant Center, Boston; 3First Hospital of Jilin University, Changchun, China; 4Brigham and Women's Hospital, Boston; 5Pathology & Cell Biology, Columbia University Medical Center, NY.

    Cardiac allograft vasculopathy (CAV) is a leading cause of death in long-term heart transplant survivors. Dense B cell infiltrates are common in heart transplants with…
  • 2016 American Transplant Congress

    Analysis of Intra-Graft Anti-HLA Antibodies Suggests That HLA Sensitization Occurs Long After an Allograft Nephrectomy and Is Not Due to a Release of Anti-HLA Antibodies from the Failed Kidney.

    D. Milongo,1 N. Congy-Jolivet,2 A. Del Bello,1 F. Sallusto,3 L. Esposito,1 L. Rostaing,1 N. Kamar.1

    1Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France; 2Department of Immunology, CHU Rangueil, Toulouse, France; 3Department of Urology and Kidney Transplantation, CHU Rangueil, Toulouse, France.

    Background: The mechanism leading to the appearance of anti-HLA antibodies and donor-specific antibodies (DSAs) after an allograft nephrectomy (NTx) is not fully understood. Two mechanisms…
  • 2016 American Transplant Congress

    Optimal Donor/Recipient Pairing for High KDPI Grafts Can Yield Similar Survival to Medium KDPI Grafts.

    M. Selim, E. Saad, M. Zimmerman, C. Johnson.

    Medical College of Wisconsin, Milwaukee.

    KDPI is a predictor of deceased-donor (DD) graft survival, calculated using donor factors. It does not consider recipient or other post-procurement factors. This retrospective analysis…
  • 2016 American Transplant Congress

    Molecular Significance of Microvascular Inflammation and C4d Negative Transplant Glomerulopathy.

    M. Lubetzky,1 P. O Broin,2 Y. Bao,1 E. Akalin.1

    1Transplantation, Albert Einstein College of Medicine, Bronx; 2School of Mathematics, Statistics & Applied Mathematics, National University of Ireland Galway University, Galway, Ireland.

    Background: Transplant glomerulopathy (TGP) is frequently found in the setting of chronic antibody mediated rejection along with microvascular inflammation (MVI) (peritubular capillaritis+glomerulitis score > 1)…
  • 2016 American Transplant Congress

    High Efficacy of Ledipasvir/Sofosbuvir with Ribavirin in HCV Genotype-1 Infected Patients with Decompensated Liver Disease: Analysis by MELD Score from the SOLAR-1 and SOLAR-2 Trials.

    M. Charlton,1 E. Yoshida,2 M. Bouliere,3 S. Flamm,4 A. Muir,5 M. Fried,6 N. Terrault,7 S. Arterburn,8 C. Yun,8 P. Pang,8 A. Osinusi,8 J. Spellman,8 M. Natha,8 D. Brainard,8 J. McHutchison,8 M. Manns,9 N. Afdhal.10

    1Intermountain Medical Center, Salt Lake City; 2Vancouver General Hospital, Vancouver, Canada; 3Hopital Saint Joseph, Marseilles, France; 4Northwestern University, Chicago; 5Duke University, Durham; 6University of North Carolina, Chapel Hill; 7UCSF, SF; 8Gilead Sciences Inc, Foster City; 9Hannover Medical School, Hannover, Germany; 10BIDMC, Boston.

    Introduction: HCV infected patients with decompensated liver disease have significant morbidity & mortality. The efficacy & safety of LDV/SOF + RBV was evaluated in a…
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