2016 American Transplant Congress
Variation in Co-Medication Use According to Kidney Transplant Immunosuppressive Regimen: Application of Integrated Registry and Pharmacy Claims Data.
Background: While modern immunosuppressive therapies (ISx) have substantially reduced acute rejection, ISx medications have many side effects, and transplant recipients must take an array of…2016 American Transplant Congress
Early Post-Transplant Patient, Graft Survival and Rejection Rates Under KAS.
Background: KAS, implemented on 12/4/14, resulted in changes in recipient, donor/recipient and tx characteristics that have the potential to affect post-tx outcomes.Data and Methods: We…2016 American Transplant Congress
Primary Outcome of iWITH: A Multi-Center Clinical Trial of Complete Immunosuppression Withdrawal (ISW) in Stable Pediatric Liver Transplant (LT) Recipients.
AIM: Test the hypothesis that a selected cohort of pediatric LT recipients can safely undergo complete ISW followed by assessment for operational tolerance (OT)METHODS: 88…2016 American Transplant Congress
Skipping Comparable Local Waitlist Candidates Under Share 35.
1Surgery, Johns Hopkins University, Baltimore, MD; 2Mathematics, US Naval Academy, Annapolis, MD.
Under Share-35, deceased donor (DD) livers are offered regionally to candidates with MELD≥35 before locally to lower MELD candidates. The characteristics and outcomes of local…2016 American Transplant Congress
Are We Refusing Good Organs? Outcomes of Ventilator Management of Sub-Optimal Lung Donors.
PurposeOptimizing donor lung function is essential for organ acceptance and successful lung transplantation (LTx). We hypothesized that ventilator management of sub-optimal donor lungs, PaO2<300 mmHg,…2016 American Transplant Congress
High Incidence of Herpes Zoster After Kidney, Liver, Heart and Lung Transplantation.
Erasmus MC, Rotterdam, Netherlands.
Background: Primary varicella zoster virus (VZV) infection causes varicella and lifelong latent infection in neural ganglia from which it may reactivate leading to herpes zoster…2016 American Transplant Congress
A Risk Quantification Score for Heart Transplants: A Heart Donor Risk Index.
Background: To better risk stratify heart transplants, we developed a continuous heart donor risk index (HDRI) based on heart donors to quantify heart allograft failure.Methods:…2016 American Transplant Congress
DEPTOR Inhibits mTORC1 in CD4+ T Cells and Increases Treg Function by Stabilizing Foxp3 Expression.
The modulation of PI-3K/Akt-induced signaling is critical for CD4+ Treg homeostasis and stability. Moreover, activation of PI-3K/Akt/mTOR signals within T cell subsets is associated with…2016 American Transplant Congress
TGFb in Regulatory B Cells-Dependent Tolerance.
Surgery, Massachusetts General Hospital, Boston, MA.
In transplantation, increasing evidence support that B cells can play a major regulatory role in addition to their critical functions in allo-immunity and graft rejection.…2016 American Transplant Congress
Transfer of Donor-Derived Exosomes to Recipient Ag-Presenting Cells Is Critical for Allograft Recognition.
After organ transplantation, T cells are primed against donor MHC molecules by donor dendritic cells (DCs) mobilized from the graft. Nevertheless, evidence suggests that donor…
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