ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

African-American Primary Renal Transplant Recipients Are at a Significantly Higher Risk to Develop De Novo DSA.

M. Everly,1 L. Rebellato,2 C. Haisch,2 K. Briley,2 P. Bolin,2 S. Kendrick,3 C. Morgan,2 A. Maldonado,4 A. Nguyen,1 P. Terasaki.1

1Terasaki Foundation Laboratory, Los Angeles
2East Carolina University, Greenville, NC
3Eastern Nephrology Associates, Greenville, NC
4Vidant Medical Center, Greenville, NC.

Meeting: 2016 American Transplant Congress

Abstract number: 385

Keywords: African-American, Alloantibodies

Session Information

Date: Tuesday, June 14, 2016

Session Name: Concurrent Session: Disparities in Transplant Access and Outcomes

Session Time: 2:30pm-4:00pm

 Presentation Time: 2:42pm-2:54pm

Location: Room 312

Related Abstracts
  • African American Race Is an Independent Risk Factor for Cytomegalovirus Infection in Renal Transplant Recipients on Low-Dose Valganciclovir Prophylaxis
  • Differing Characteristics of New-Onset Diabetes after Transplantation (NODAT) in African-American Compared to Non-African-American Kidney Recipients

Recent studies have shown multiple risk factors for de novo DSA (dnDSA) development. One controversial risk factor is race. Studying a primarily African-American (AA) transplant population, we aimed to assess whether transplant recipients' of African American race had similar dnDSA incidence rates, dnDSA risk factors, and dnDSA related outcomes.

Methods:We performed a single center analysis of 158 HLA mismatched patients receiving a primary transplant between 1/06 to 12/10. All patients underwent frequent HLA IgG antibody monitoring by single antigen beads pre-transplant, post-transplant at 1,3,6,9,12 months, and annually, thereafter. All patients were DSA negative at time of transplantation.

Results: 106/158 transplant patients were AA. Of the 106 AA patients 49% developed dnDSA by 5 years compared to 27% in the non-AA group (p=0.0072, Fig A). Among AA patients, donor type did not differentiate risk for dnDSA. Of all other potential risk factors in AA patients, HLA-DQ mismatch, Non-adherence and BK viremia (pre-dnDSA) were the most common clinical and demographic dnDSA antecedents (Fig B). In AA patients, pre-transplant hypertension and choice of tacrolimus (as the calcineurin inhibitor) were found to prevent dnDSA formation in AA patients. In the non-AA group, we were unable to establish a clear set of factors to serve as possible predictors. Even though more AA patients developed dnDSA and subsequently experienced graft failure, the rate of post-dnDSA graft failure did not differ between AA and non-AA patients (Fig C). The actual 3 year post-dnDSA allograft failure was 30% for both groups.

Conclusion: Studying a predominantly AA cohort enabled us to show that the risk of de novo DSA is higher in AA than non-AA patients. As a result AA primary transplant recipients are at a higher risk of failure, especially if they are DQ mismatched or are at risk for BK viremia or nonadherence.

CITATION INFORMATION: Everly M, Rebellato L, Haisch C, Briley K, Bolin P, Kendrick S, Morgan C, Maldonado A, Nguyen A, Terasaki P. African-American Primary Renal Transplant Recipients Are at a Significantly Higher Risk to Develop De Novo DSA. Am J Transplant. 2016;16 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Everly M, Rebellato L, Haisch C, Briley K, Bolin P, Kendrick S, Morgan C, Maldonado A, Nguyen A, Terasaki P. African-American Primary Renal Transplant Recipients Are at a Significantly Higher Risk to Develop De Novo DSA. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/african-american-primary-renal-transplant-recipients-are-at-a-significantly-higher-risk-to-develop-de-novo-dsa/. Accessed March 6, 2021.

« Back to 2016 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Role of Mitochondria, Metabolism and Inflammation: Pathways Influencing Short Term Outcomes Post-Renal Transplantation
    • Factors Influencing Creatinine Rise Following Donor Nephrectomy

    Visit Our Partner Sites

    American Transplant Congress (ATC)

    Visit the official site for the American Transplant Congress »

    American Journal of Transplantation

    The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

    American Society of Transplantation (AST)

    An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

    American Society of Transplant Surgeons (ASTS)

    The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

    Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

    Privacy Policy

    loading Cancel
    Post was not sent - check your email addresses!
    Email check failed, please try again
    Sorry, your blog cannot share posts by email.
    This site uses cookies: Find out more.